992 resultados para twisted canonical homomorphism
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Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFα, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles. Our data also demonstrate that RHBDL4-dependent trafficking control is regulated by G-protein coupled receptors, suggesting a role for this rhomboid protease in pathological conditions, including EGFR signaling. We propose that RHBDL4 reorganizes trafficking events within the early secretory pathway in response to GPCR signaling. Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of specific membrane protein cargoes.
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"UILU-ENG 79 1727."
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Mode of access: Internet.
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All of the numbered plates in the atlas are double plates, and thus are counted twice in the adjusted plate count.
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Mode of access: Internet.
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"First edition printed April 1894...twenty--ninth printing 1970."
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Mode of access: Internet.
A dissertation on the origin and composition of our three first canonical gospels, by Herbert Marsh.
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Includes bibliographical references.
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Mode of access: Internet.