On developing efficient applications using conservative distributed simulation paradigm

This paper aims to present, using a set of guidelines, how to apply the conservative distributed simulation paradigm (CMB protocol) to develop efficient applications. Using these guidelines, even a user with little experience on distributed simulation and computer architecture can have good performance on distributed simulations using conservative synchronization protocols for parallel processes.The set of guidelines is focus on a specific application domain, the performance evaluation of computer systems, considering models with coarse granularity and few logical processes and running over two platforms: parallel (high performance communication environment) and distributed (low performance communication environment).

Paracellular Absorption: A Bat Breaks the Mammal Paradigm

Bats tend to have less intestinal tissue than comparably sized nonflying mammals. The corresponding reduction in intestinal volume and hence mass of digesta carried is advantageous because the costs of flight increase with load carried and because take-off and maneuverability are diminished at heavier masses. Water soluble compounds, such as glucose and amino acids, are absorbed in the small intestine mainly via two pathways, the transporter-mediated transcellular and the passive, paracellular pathways. Using the microchiropteran bat Artibeus literatus (mean mass 80.6 +/- 3.7 g), we tested the predictions that absorption of water-soluble compounds that are not actively transported would be extensive as a compensatory mechanism for relatively less intestinal tissue, and would decline with increasing molecular mass in accord with sieve-like paracellular absorption. Using a standard pharmacokinetic technique, we fed, or injected intraperitonealy the metabolically inert carbohydrates L-rhamnose (molecular mass = 164 Da) and cellobiose (molecular mass = 342 Da) which are absorbed only by paracellular transport, and 3-O-methyl-D-glucose (3OMD-glucose) which is absorbed via both mediated (active) and paracellular transport. As predicted, the bioavailability of paracellular probes declined with increasing molecular mass (rhamnose, 90 +/- 11%; cellobiose, 10 +/- 3%, n = 8) and was significantly higher in bats than has been reported for laboratory rats and other mammals. In addition, absorption of 3OMD-glucose was high (96 +/- 11%). We estimated that the bats rely on passive, paracellular absorption for more than 70% of their total glucose absorption, much more than in non-flying mammals. Although possibly compensating for less intestinal tissue, a high intestinal permeability that permits passive absorption might be less selective than a carrier-mediated system for nutrient absorption and might permit toxins to be absorbed from plant and animal material in the intestinal lumen.

Implication of the 5-HT(2A) and 5-HT(2C) (but not 5HT(1A)) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Integration of the feminine into Latin American culture: in search of a new social paradigm

Includes bibliography

An assessment of the structuralist paradigm for Latin American development and the prospects for its renovation

Includes bibliography

Industrial revolution, technological paradigm and regional alternatives

Includes bibliography

The State, business and the restoration of the neoclassical paradigm

Includes bibliography

A biosocial paradigm for women's gender roles

Includes bibliography

Fostering a transport policy paradigm shift: comprehensiveness, sustainability and co-modality

This issue of the FAL Bulletin proposes a paradigm shift away from the traditional approach to transport policy in the region, so as to better address issues associated with development. It suggests working towards an integrated and sustainable infrastructure, logistics and mobility policy structure based on the principle of co- modality.

Towards a new paradigm for urban public transport: the transmilenio case

The process of urbanization in Latin America presents new challenges for urban transport systems insofar as one of the priorities is to provide proper mobility for the increasing and complex interaction of communities.This edition of the Bulletin, prepared by Irma Chaparro, presents a summary of the recent study entitled Evaluación del impacto socio-económico del transporte urbano en la ciudad de Bogotá. El caso del sistema masivo de transporte, Transmilenio, LC/L 1786-P, October 2002, which considers the socioeconomic impact of the Transmilenio system in Bogotá. This system is part of an integrated transport strategy promoted by the District Authority over the period 1998-2001 and is an avant-garde solution to the difficult problem of transport in the city.