Innovative Solutions for Slope Stability Reinforcement and Characterization: Vol. III, TR-489, 2005

Soil slope instability concerning highway infrastructure is an ongoing problem in Iowa, as slope failures endanger public safety and continue to result in costly repair work. Volume I of this current study summarizes research methods and findings, while Volume II provides procedural details for incorporating into practice an infrequently-used testing technique–borehole shear tests. Volume III of this study of field investigation of fifteen slopes in Iowa demonstrates through further experimental testing how lateral forces develop along stabilizing piles to resist slope movements. Results establish the feasibility of an alternative stabilization approach utilizing small-diameter pile elements. Also, a step-by-step procedure that can be used by both state and county transportation agencies to design slope reinforcement using slender piles is documented. Initial evidence of the efficiency and cost-effectiveness of stabilizing nuisance slope failures with grouted micropiles is presented. Employment of the remediation alternative is deemed more appropriate for stabilizing shallow slope failures. Overall, work accomplished in this research study included completing a comprehensive literature review on the state of the knowledge of slope stability and slope stabilization, the preparation and performance of fourteen full-scale pile load tests, the analysis of load test results, and the documentation of a design methodology for implementing the technology into current practices of slope stabilization. Recommendations for further research include monitoring pilot studies of slope reinforcement with grouted micropiles, supplementary experimental studies, and advanced numerical studies.

Thermoset Composite Concrete Reinforcement, HR-325, Part 1, 1992

The feasibility of substituting fibercomposite (FC) (thermoset) pavement dowels for steel pavement dowels was investigated in this research project. Load transfer capacity, flexural capacity, and material properties were examined. The objectives of Part 1 of this final report included the shear behavior and strength deformations of FC dowel bars without aging. Part 2 will contain the aging effects. This model included the effects of modulus of elasticity for the pavement dowel and concrete, dowel diameter, subgrade stiffness, and concrete compressive strength. An experimental investigation was carried out to establish the modulus of dowel support which is an important parameter for the analysis of dowels. The experimental investigation included measured deflections, observed behavioral characteristics, and failure mode observations. An extensive study was performed on various shear testing procedures. A modified Iosipescu shear method was selected for the test procedure. Also, a special test frame was designed and fabricated for this procedure. The experimental values of modulus of support for shear and FC dowels were used for arriving at the critical stresses and deflections for the theoretical model developed. Different theoretical methods based on analyses suggested by Timoshenko, Friberg, Bradbury, and Westergaard were studied and a comprehensive theoretical model was developed. The fibercomposite dowels were found to provide strengths and behavioral characteristics that appear promising as a potential substitute for steel dowels.

Velar verbs and verbal classes in catalan

There is in Catalan a set of verbs, the so-called «velar verbs», whose differential characteristic consists in presenting a velar segment between the root and the inflectional suffixes in certain morphosyntactic contexts. This velar segment has traditionally been considered as being part of the root in the contexts where it occurs, and has been made responsible for the typical allomorphic character of velar verbs. Under the assumption that regular verbs are only one-root verbs, velar verbs have been treated as irregular verbs. Nevertheless, neither the phonic character of the velar segment nor the marginal character of velar verbs is clear. The aim of this paper is to present a different account of velar verbs on the basis of the inflectional morphological character of the velar segment. The work is split into two parts. The first one focuses on standard Catalan, and tries to show that in this variety velar verbs are better treated as regular verbs. The second one focuses on other Catalan varieties, and aims to exhibit the incoherence implied in the traditional treatment of velar verbs in the context of the Catalan language as a whole. The discussion is mainly developed on morphological grounds, halfway between theory and description.

Mediastinal reinforcement after induction therapy and pneumonectomy: comparison of intercostal muscle versus diaphragm flaps.

OBJECTIVE: Prospective non-randomised comparison of full-thickness pedicled diaphragm flap with intercostal muscle flap in terms of morbidity and efficiency for bronchial stump coverage after induction therapy followed by pneumonectomy for non-small cell lung cancer (NSCLC). METHODS: Between 1996 and 1998, a consecutive series of 26 patients underwent pneumonectomy following induction therapy. Half of the patients underwent mediastinal reinforcement by use of a pedicled intercostal muscle flap (IF) and half of the patients by use of a pedicled full-thickness diaphragm muscle flap (DF). Patients in both groups were matched according to age, gender, side of pneumonectomy and stage of NSCLC. Postoperative morbidity and mortality were recorded. Six months follow-up including physical examination and pulmonary function testing was performed to examine the incidence of bronchial stump fistulae, gastro-esophageal disorders or chest wall complaints. RESULTS: There was no 30-day mortality in both groups. Complications were observed in one of 13 patients after IF and five of 13 after DF including pneumonia in two (one IF and one DF), visceral herniations in three (DF) and bronchopleural fistula in one patient (DF). There were no symptoms of gastro-esophageal reflux disease (GERD). Postoperative pulmonary function testing revealed no significant differences between the two groups. CONCLUSIONS: Pedicled intercostal and diaphragmatic muscle flaps are both valuable and effective tools for prophylactic mediastinal reinforcement following induction therapy and pneumonectomy. In our series of patients, IF seemed to be associated with a smaller operation-related morbidity than DF, although the difference was not significant. Pedicled full-thickness diaphragmatic flaps may be indicated after induction therapy and extended pneumonectomy with pericardial resection in order to cover the stump and close the pericardial defect since they do not adversely influence pulmonary function.

Les observacions de classes al servei de la didàctica de la llengua estrangera

La autora revisa diferentes usos de las observaciones de clases, en particular en lo que se refiere a las clases de lengua extrangera, tanto en investigación como en formación. A partir de algunos ejemplos, identifica, entre la diversidad de formas de aplicación, objetivos diferentes y modelos de formación diversos, considerando que éstos no se excluyen sino que se complementan, según su adecuación a cada situación de formación. Se comentan algunos problemas con el fin de iniciar una reflexión sobre la aplicación de las observaciones de clase a la formación, que debería proseguir con trabajos de investigación y encuentros de formadores.

Alfabetització, cultura escrita i classes populars a l'època contemporània

Aquest article se centra en l'estudi de la relació de les classes populars amb la cultura escrita a l'època contemporània. Els exemples que s'exposen es refereixen bàsicament a la ciutat de Reus al segle XIX, tot i que també hi ha altres referències. En un primer moment s'estudia l'accés de les classes populars a la cultura escrita a través de l'escola. També hi ha una anàlisi d'alguns àmbits extraacadèmics on hom pot obtenir els mecanismes per accedir a la lectura i l'escriptura. Entre ells s'han escollit les associacions i les presons. Finalment, s'analitzen alguns testimonis escrits de les classes populars.

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported to be effective inhibitors of MIF tautomerase activity in vitro. Herein we employed a robust activity-based assay to identify different classes of novel inhibitors of the catalytic and biological activities of MIF. Several novel chemical classes of inhibitors of the catalytic activity of MIF with IC(50) values in the range of 0.2-15.5 microm were identified and validated. The interaction site and mechanism of action of these inhibitors were defined using structure-activity studies and a battery of biochemical and biophysical methods. MIF inhibitors emerging from these studies could be divided into three categories based on their mechanism of action: 1) molecules that covalently modify the catalytic site at the N-terminal proline residue, Pro(1); 2) a novel class of catalytic site inhibitors; and finally 3) molecules that disrupt the trimeric structure of MIF. Importantly, all inhibitors demonstrated total inhibition of MIF-mediated glucocorticoid overriding and AKT phosphorylation, whereas ebselen, a trimer-disrupting inhibitor, additionally acted as a potent hyperagonist in MIF-mediated chemotactic migration. The identification of biologically active compounds with known toxicity, pharmacokinetic properties, and biological activities in vivo should accelerate the development of clinically relevant MIF inhibitors. Furthermore, the diversity of chemical structures and mechanisms of action of our inhibitors makes them ideal mechanistic probes for elucidating the structure-function relationships of MIF and to further determine the role of the oligomerization state and catalytic activity of MIF in regulating the function(s) of MIF in health and disease.

Aspectes metodològics i técnica d'analisi en l'estudi dels grups i les classes socials

En aquest article es presenta el procés metodològic, com també les tècniques d'anàlisi de dades, que s'ha utilitzat en l'anàisi dels grups socials mitjançant la informació d'una gran enquesta sobre hàbits i condicions de vida. L'anàlisi dels grups socials des d'una perspectiva globalitzadora i estructuradora de les condicions de vida, tenint en compte com aquests sorgeixen mitjançant I 'associació i la coherència entre múltiples característiques. Les tècniques d'anàlisi de dades que s'han utilitzat han estat l'anàlisi de correspondències múltiples i l'anàlisi de classificació.

Retaining Wall - Modular Unit Reinforced Earth Tensar Geogrid Reinforcement, HR-549, 1998

This research, initiated in October 1992, was located at the intersection of Blairs Ferry Road and Lindale Drive in the City of Marion. The wall is located on the southeast corner of the intersection. Reinforced retaining wall construction started with a five inch base of roadstone with one inch of sand for leveling purposes. One and one-half to two feet of one inch clean stone was placed behind the blocks. A four inch perforated plastic pipe was placed approximately nine inches from the bottom of the one inch clean stone. The Tenswal, tensar geogrid was placed at every third layer. Openings in the Tenswal are hooked over plastic dowels in the blocks. The tenswal reaches from the face of the wall back 5' to 8'. The cost for constructing this wall was $124,400. The wall has performed well for the past five years. The wall improves the aesthetics of a high traffic volume intersection of an urban area. Many positive comments have been received by the city regarding its appearance. The City of Marion has been pleased with the wall and has used this type of wall on subsequent projects.

Les classes sociales : analyse de la vie sociale / par Arthur Bauer,...

Collection : Bibliothèque sociologique internationale ; 25

Speciation genetics: reinforcement by shades and hues.

Mating with a member of another species can seriously reduce an organism's fitness, so mechanisms ought to evolve to prevent it where hybridizing species meet. This old idea of 'reinforcement' has found new support in an elegant pair of studies of the ecological genetics of flower colour in an annual herb.