FPGA based Streaming Image Processing Processor (SIPPro) architecture to accelerate data intensive applications

Current data-intensive image processing applications push traditional embedded architectures to their limits. FPGA based hardware acceleration is a potential solution but the programmability gap and time consuming HDL design flow is significant. The proposed research approach to develop “FPGA based programmable hardware acceleration platform” that uses, large number of Streaming Image processing Processors (SIPPro) potentially addresses these issues. SIPPro is pipelined in-order soft-core processor architecture with specific optimisations for image processing applications. Each SIPPro core uses 1 DSP48, 2 Block RAMs and 370 slice-registers, making the processor as compact as possible whilst maintaining flexibility and programmability. It is area efficient, scalable and high performance softcore architecture capable of delivering 530 MIPS per core using Xilinx Zynq SoC (ZC7Z020-3). To evaluate the feasibility of the proposed architecture, a Traffic Sign Recognition (TSR) algorithm has been prototyped on a Zedboard with the color and morphology operations accelerated using multiple SIPPros. Simulation and experimental results demonstrate that the processing platform is able to achieve a speedup of 15 and 33 times for color filtering and morphology operations respectively, with a significant reduced design effort and time.

Associations between intensive diabetes therapy and NMR-determined lipoprotein subclass profiles in Type 1 diabetes

Our objective is to define differences in circulating lipoprotein subclasses between intensive vs. conventional management of Type 1 diabetes during the randomization phase of the Diabetes Control and Complications Trial (DCCT). Nuclear magnetic resonance-determined lipoprotein subclass profiles (NMR-LSP), which estimate molar subclass concentrations and mean particle diameters, were determined in 1,294 DCCT subjects after a median of five (interquartile range: four, six) years following randomization to intensive or conventional diabetes management. In cross-sectional analyses, we compared standard lipids and NMR-LSP between treatment groups. Standard total-, LDL- and HDL-cholesterol levels were similar between randomization groups, while triglyceride levels were lower in the intensively treated group. NMR-LSP showed that intensive therapy was associated with larger LDL diameter (20.7 vs. 20.6 nm, p=0.01) and lower levels of small LDL (median: 465 vs. 552 nmol/l, p=0.007), total IDL/LDL (mean: 1000 vs. 1053 nmol/l, p=0.01), and small HDL (mean: 17.3 vs. 18.6 μmol/l, p<0.0001), the latter accounting for reduced total HDL (mean: 33.8 vs. 34.8 μmol/l, p=0.01). In conclusion, intensive diabetes therapy was associated with potentially favorable changes in LDL and HDL subclasses in sera. Further research will determine whether these changes contribute to the beneficial effects of intensive diabetes management on vascular complications.

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

Importance Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS).

Objectives To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts—for example prone positioning—in routine clinical practice for patients fulfilling the ARDS Berlin Definition.

Design, Setting, and Participants The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents.

Exposures Acute respiratory distress syndrome.

Main Outcomes and Measures The primary outcome was ICU incidence of ARDS. Secondary outcomes included assessment of clinician recognition of ARDS, the application of ventilatory management, the use of adjunctive interventions in routine clinical practice, and clinical outcomes from ARDS.

Results Of 29 144 patients admitted to participating ICUs, 3022 (10.4%) fulfilled ARDS criteria. Of these, 2377 patients developed ARDS in the first 48 hours and whose respiratory failure was managed with invasive mechanical ventilation. The period prevalence of mild ARDS was 30.0% (95% CI, 28.2%-31.9%); of moderate ARDS, 46.6% (95% CI, 44.5%-48.6%); and of severe ARDS, 23.4% (95% CI, 21.7%-25.2%). ARDS represented 0.42 cases per ICU bed over 4 weeks and represented 10.4% (95% CI, 10.0%-10.7%) of ICU admissions and 23.4% of patients requiring mechanical ventilation. Clinical recognition of ARDS ranged from 51.3% (95% CI, 47.5%-55.0%) in mild to 78.5% (95% CI, 74.8%-81.8%) in severe ARDS. Less than two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight. Plateau pressure was measured in 40.1% (95% CI, 38.2-42.1), whereas 82.6% (95% CI, 81.0%-84.1%) received a positive end-expository pressure (PEEP) of less than 12 cm H2O. Prone positioning was used in 16.3% (95% CI, 13.7%-19.2%) of patients with severe ARDS. Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning. Hospital mortality was 34.9% (95% CI, 31.4%-38.5%) for those with mild, 40.3% (95% CI, 37.4%-43.3%) for those with moderate, and 46.1% (95% CI, 41.9%-50.4%) for those with severe ARDS.

Conclusions and Relevance Among ICUs in 50 countries, the period prevalence of ARDS was 10.4% of ICU admissions. This syndrome appeared to be underrecognized and undertreated and associated with a high mortality rate. These findings indicate the potential for improvement in the management of patients with ARDS.

Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

BACKGROUND: Care of critically ill patients in intensive care units (ICUs) often requires potentially invasive or uncomfortable procedures, such as mechanical ventilation (MV). Sedation can alleviate pain and discomfort, provide protection from stressful or harmful events, prevent anxiety and promote sleep. Various sedative agents are available for use in ICUs. In the UK, the most commonly used sedatives are propofol (Diprivan(®), AstraZeneca), benzodiazepines [e.g. midazolam (Hypnovel(®), Roche) and lorazepam (Ativan(®), Pfizer)] and alpha-2 adrenergic receptor agonists [e.g. dexmedetomidine (Dexdor(®), Orion Corporation) and clonidine (Catapres(®), Boehringer Ingelheim)]. Sedative agents vary in onset/duration of effects and in their side effects. The pattern of sedation of alpha-2 agonists is quite different from that of other sedatives in that patients can be aroused readily and their cognitive performance on psychometric tests is usually preserved. Moreover, respiratory depression is less frequent after alpha-2 agonists than after other sedative agents.

OBJECTIVES: To conduct a systematic review to evaluate the comparative effects of alpha-2 agonists (dexmedetomidine and clonidine) and propofol or benzodiazepines (midazolam and lorazepam) in mechanically ventilated adults admitted to ICUs.

DATA SOURCES: We searched major electronic databases (e.g. MEDLINE without revisions, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE and Cochrane Central Register of Controlled Trials) from 1999 to 2014.

METHODS: Evidence was considered from randomised controlled trials (RCTs) comparing dexmedetomidine with clonidine or dexmedetomidine or clonidine with propofol or benzodiazepines such as midazolam, lorazepam and diazepam (Diazemuls(®), Actavis UK Limited). Primary outcomes included mortality, duration of MV, length of ICU stay and adverse events. One reviewer extracted data and assessed the risk of bias of included trials. A second reviewer cross-checked all the data extracted. Random-effects meta-analyses were used for data synthesis.

RESULTS: Eighteen RCTs (2489 adult patients) were included. One trial at unclear risk of bias compared dexmedetomidine with clonidine and found that target sedation was achieved in a higher number of patients treated with dexmedetomidine with lesser need for additional sedation. The remaining 17 trials compared dexmedetomidine with propofol or benzodiazepines (midazolam or lorazepam). Trials varied considerably with regard to clinical population, type of comparators, dose of sedative agents, outcome measures and length of follow-up. Overall, risk of bias was generally high or unclear. In particular, few trials blinded outcome assessors. Compared with propofol or benzodiazepines (midazolam or lorazepam), dexmedetomidine had no significant effects on mortality [risk ratio (RR) 1.03, 95% confidence interval (CI) 0.85 to 1.24, I (2) = 0%; p = 0.78]. Length of ICU stay (mean difference -1.26 days, 95% CI -1.96 to -0.55 days, I (2) = 31%; p = 0.0004) and time to extubation (mean difference -1.85 days, 95% CI -2.61 to -1.09 days, I (2) = 0%; p < 0.00001) were significantly shorter among patients who received dexmedetomidine. No difference in time to target sedation range was observed between sedative interventions (I (2) = 0%; p = 0.14). Dexmedetomidine was associated with a higher risk of bradycardia (RR 1.88, 95% CI 1.28 to 2.77, I (2) = 46%; p = 0.001).

LIMITATIONS: Trials varied considerably with regard to participants, type of comparators, dose of sedative agents, outcome measures and length of follow-up. Overall, risk of bias was generally high or unclear. In particular, few trials blinded assessors.

CONCLUSIONS: Evidence on the use of clonidine in ICUs is very limited. Dexmedetomidine may be effective in reducing ICU length of stay and time to extubation in critically ill ICU patients. Risk of bradycardia but not of overall mortality is higher among patients treated with dexmedetomidine. Well-designed RCTs are needed to assess the use of clonidine in ICUs and identify subgroups of patients that are more likely to benefit from the use of dexmedetomidine.

STUDY REGISTRATION: This study is registered as PROSPERO CRD42014014101.

FUNDING: The National Institute for Health Research Health Technology Assessment programme. The Health Services Research Unit is core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates.

Energy Optimization of Memory Intensive Parallel Workloads

Energy consumption is an important concern in modern multicore processors. The energy consumed by a multicore processor during the execution of an application can be minimized by tuning the hardware state utilizing knobs such as frequency, voltage etc. The existing theoretical work on energy minimization using Global DVFS (Dynamic Voltage and Frequency Scaling), despite being thorough, ignores the time and the energy consumed by the CPU on memory accesses and the dynamic energy consumed by the idle cores. This article presents an analytical energy-performance model for parallel workloads that accounts for the time and the energy consumed by the CPU chip on memory accesses in addition to the time and energy consumed by the CPU on CPU instructions. In addition, the model we present also accounts for the dynamic energy consumed by the idle cores. The existing work on global DVFS for parallel workloads shows that using a single frequency for the entire duration of a parallel application is not energy optimal and that varying the frequency according to the changes in the parallelism of the workload can save energy. We present an analytical framework around our energy-performance model to predict the operating frequencies (that depend upon the amount of parallelism) for global DVFS that minimize the overall CPU energy consumption. We show how the optimal frequencies in our model differ from the optimal frequencies in a model that does not account for memory accesses. We further show how the memory intensity of an application affects the optimal frequencies.

Technology-related strategies in labour-intensive industries from Southern European Regions: consequences for local employment

Tese dout., Economia, Universidade do Algarve, 2010

Impact de la monoparentalité et de la pauvreté combinées sur l'évolution des familles bénéficiant d'une intervention brève intensive de crise

L'objectif de la présente étude vise à documenter l'évolution de familles confrontées à la monoparentalité et la pauvreté suite à une intervention brève et intensive de crise. Pour atteindre cet objectif, nous avons procédé à la comparaison de l'évolution de deux sous-groupes de familles soit des familles monoparentales bénéficiant d'un revenu familial annuel faible (moins de $40,000/année) (familles défavorisées) (n=10) et des familles biparentales bénéficiant d'un revenu familial annuel plus favorable (plus de $40,000/année) (familles favorisées) (n=50). Les caractéristiques des familles ont été évaluées à 2 reprises, soit après la deuxième semaine suivant le début du suivi et 12 mois plus tard. Les questionnaires qui ont été retenus dans la présente étude visaient à évaluer différentes dimensions du fonctionnement familial notamment la résolution de problème, la communication, les rôles, l'investissement affectif, l'expression affective, le contrôle des comportements et le fonctionnement familial général ( Family Assessment Device de Epstein et al. , 1983) et certaines caractéristiques des pratiques éducatives des parents soit l'engagement parental, les comportements parentaux positifs, la supervision parentale et la discipline inconsistante (Alabama Parenting Questionnaire de Shelton et al ., 1995). Les premières analyses comparatives ont permis de constater que globalement, du point de vue des adolescents, l'ensemble des familles ont connu en moyenne une évolution positive sur la plupart des dimensions évaluées concernant le fonctionnement familial sauf en ce qui concerne l'investissement affectif et le contrôle des comportements. De même, les adolescents rapportent que les pratiques éducatives ont évolué positivement sur les plans de l'engagement des parents et des pratiques parentales positives. De plus, selon le point de vue des parents répondants, il apparaît que les familles ont connu une évolution positive sur l'ensemble des dimensions mesurées concernant le fonctionnement de la famille. En outre, il ressort que les familles ne connaissent pas d'évolution significative suite à l'intervention sur la presque totalité des dimensions mesurées concernant les pratiques éducatives sauf en ce qui concerne la discipline inconsistante. D'autres analyses comparatives concernant l'évolution des familles défavorisées comparativement aux familles favorisées suite à l'intervention ont permis de constater que les familles défavorisées connaissent une évolution positive plus importante sur les plans de la distribution des rôles, de l'investissement affectif, du contrôle des comportements et de la discipline inconsistante selon le point de vue des parents répondants. Par ailleurs, on note, selon le point de vue des adolescents, une évolution négative plus importante des familles défavorisées sur les plans du contrôle des comportements comparativement aux familles favorisées.

Les caractéristiques des jeunes et des parents associées à l'évolution de l'alliance thérapeutique en contexte d'intervention brève et intensive de crise familiale

La présente étude visait à identifier les caractéristiques des jeunes et des parents (telles que la présence de troubles internalisés chez le jeune, la présence de troubles externalisés chez le jeune, l'estime de soi du jeune, la détresse psychologique des parents, les ressources interpersonnelles du parent, la qualité de la communication dans la famille, la cohésion familiale, l'intensité et la fréquence des conflits conjugaux) associées à l'évolution de l'alliance thérapeutique en contexte d'intervention brève et intensive de crise familiale. Pour atteindre cet objectif, nous avons effectué une étude corrélationnelle et descriptive avec deux temps de mesure de l'alliance thérapeutique. Notre échantillon est composé de 96 familles participantes au programme d'intervention Crise-Ado-Famille-Enfance. Selon les résultats obtenus, la perception de l'évolution de l'alliance thérapeutique des jeunes participant au programme CAFE ne semble pas être influencée significativement par aucune des caractéristiques recensées pour la présente étude. Au niveau de la perception de l'évolution de l'alliance thérapeutique des parents, les résultats révèlent qu'une seule des caractéristiques des jeunes et des familles y est associée de façon significative, soit la présence de troubles internalisés chez le jeune.

University Summer Quarter Chorus and High School Music Intensive Orchestra, July 11, 1940

Concert program for Summer Quarter Music, July 11, 1940

The influence of multimorbidity on hospital, intensive care, and emergency department use at the end of life for patients with chronic conditions

Thesis (Master's)--University of Washington, 2016-03

Demsi - a demand response simulator in the context of intensive use of distributed generation

Demand response can play a very relevant role in future power systems in which distributed generation can help to assure service continuity in some fault situations. This paper deals with the demand response concept and discusses its use in the context of competitive electricity markets and intensive use of distributed generation. The paper presents DemSi, a demand response simulator that allows studying demand response actions and schemes using a realistic network simulation based on PSCAD. Demand response opportunities are used in an optimized way considering flexible contracts between consumers and suppliers. A case study evidences the advantages of using flexible contracts and optimizing the available generation when there is a lack of supply.

Energy Resource Management under the Influence of the Weekend Transition Considering an Intensive use of Electric Vehicles

Energy resource scheduling is becoming increasingly important, as the use of distributed resources is intensified and of massive electric vehicle is envisaged. The present paper proposes a methodology for day-ahead energy resource scheduling for smart grids considering the intensive use of distributed generation and Vehicle-to-Grid (V2G). This method considers that the energy resources are managed by a Virtual Power Player (VPP) which established contracts with their owners. It takes into account these contracts, the users' requirements subjected to the VPP, and several discharge price steps. The full AC power flow calculation included in the model takes into account network constraints. The influence of the successive day requirements on the day-ahead optimal solution is discussed and considered in the proposed model. A case study with a 33-bus distribution network and V2G is used to illustrate the good performance of the proposed method.