lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014

Ostrich egg-shell cups of Mesopotamia and the ostrich in ancient and modern times / by Berthold Laufer. 9 plates and 10 text-figures.

no.23(1926)

The giraffe in history and art / by Berthold Laufer, Curator of Anthropology. 9 plates in photogravure, 23 text-figures, and 1 vignette.

no.27(1928)

Employment by lotto revisited

We study employment by lotto (Aldershof et al., 1999), a matching algorithm for the so-called stable marriage problem. We complement Aldershof et al.'s analysis in two ways. First, we give an alternative and intuitive description of employment by lotto. Second, we disprove Aldershof et al.'s conjectures concerning employment by lotto for general matching markets.

Refilling meridians in a genus 2 handlebody complement

Suppose a genus two handlebody is removed from a 3-manifold M and then a single meridian of the handlebody is restored. The result is a knot or link complement in M and it is natural to ask whether geometric properties of the link complement say something about the meridian that was restored. Here we consider what the relation must be between two not necessarily disjoint meridians so that restoring each of them gives a trivial knot or a split link.

¡Hasta la última papeleta! Las elecciones italianas del 9 y 10 de abril de 2006

La oposición de centro-izquierda ha ganado las elecciones italianas de 9/10 abril 2006 por solamente 24.000 votos, lo 0,6 por ciento de 38 millones de electores. Ha ganado también la mayoría de los escaños en el Senado gracias al voto de los italianos en el extranjero. Como la mayoría en el Senado es de solamente dos escaños y como el Senado tiene los mismos poderes de la otra cámara, el Gobierno Prodi, que ha sustituido después de cinco años lo de Berlusconi, puede tener una vida muy difícil. Cuanto al sistema de partido salido de las elecciones, eso se confirma el modelo de “bipolarismo fragmentado”: se ha realizado la alternancia en el poder por la tercera vez consecutiva y se han mantenido dentro de las dos coaliciones muchos partidos tal vez conflictivos entre ellos.

Biblioteca Digital de Cataluña : Continente y contenido. 5ª Jornada sobre la Biblioteca Digital Universitaria, Los Polvorines (Argentina), 8 y 9 de noviembre de 2007

Desde 1999 el Consorcio de Bibliotecas Universitarias de Cataluña (CBUC) ha creado una nueva línea de trabajo, junto con el Centro de Supercomputación de Cataluña (CESCA), para promocionar la investigación que se lleva a cabo en Cataluña y al mismo tiempo contribuir al movimiento mundial de depositar la producción académica y de investigación en la red de forma gratuita. Este movimiento mundial, que recibe el nombre de Open Access, ha sido puesto en marcha por las instituciones que financian la investigación con la finalidad de crear alternativas al paradigma de pagar por tener acceso a la información que se ha elaborado en la propia institución. Esta nueva línea de trabajo son los repositorios institucionales. En la tercera edición de estas mismas Jornadas presentamos una comunicación sobre los repositorios institucionales que por entonces teníamos implementados. Ahora después de dos años presentamos su estado actual y reflexionamos sobre la estrategia para lograr la inclusión de documentos (políticas institucionales, comités científicos, etc.), su contenido (estándares usados, derechos de autor, preservación, etc.), su continente (programas y tecnología utilizada, protocolos, etc.) y comentamos los resultados obtenidos en los seis años de experiencia desde que se puso en marcha el primero.

Contribution to the study of immune hemolysis by toad complement

EA (sheep erythrocytes carrying rabbit antibody) are lysed by toad complement under optimal conditions which include a low concentration of cells (1.54 x 10*8/ml), a low temperature of incubation (30°C) and the same amounts of Ca++ and Mg++ as required for the titration of guinea-pig complement. Kinetic studies of the role of cations mentioned above in immune lysis by toad C have disclosed a fundamental difference as compared to guinea-pig C. In a limited complement system, the lysis by amphibian C is completely blocked by EDTA, even when the chelating agent is added as late as 15 minutes after zero-time. Inhibition by EGTA is only partial and the findings suggest that Mg++ is required not only at the beginning, but also at late stages of the lytic process. It has been speculated that the activation of amphibian complement proceeds mainly by the alternative pathway.

Estudo da patogenicidade para camundongos recém-nascidos de amostras de echovirus tipo 9 isoladas de casos de meningite durante um surto epidêmico no Rio de Janeiro

A patogenicidade do echovirus tipo 9 para camundongos recém-nascidos foi estudada, utilizando-se 12 amostras isoladas em cultura de células primárias de rim de macaco, a partir do liquor de crianças com meningite. Os animais inoculados com o fluido da primeira passagem em células desenvolveram paralisia flácida, após um período de 5 dias, com a morte ate o 8º dia. Os especimens originais de liquor não continham suficiente vírus para provocar sinais clínicos nos animais inoculados no período de 21 dias de observação. Ao exame histopatológico os animais doentes apresentaram miopatia necrotizante da musculatura paravertebral, língua e diafragma. Animais inoculados que não desenvolveram paralisia durante o período de observação apresentaram miosite discreta, sem que tenha sido encontrada necrose das fibras musculares.

Full Tècnic. Conreus Extensius. Comarques de Girona, núm. 9 (2007)

Es presenta un resum dels resultats dels assaigs d’avaluació de varietats de blat tou obtinguts en el marc de la Xarxa d’Experimentació de Varietats de l’IRTA.

Prevention of bone marrow graft failure by an anti LFA-1 monoclonal antibody

Graft rejection is the major cause of failure of HLA mismatched bone marrow transplantation because of residual host immunity. we have proposed to use a monoclonal murine antibody specific for the LFA-1 molecule (25-3) to prevent graft failure in HLA mismatched bone marrow transplantation (BMT). The rationale for this approach is three fold: LFA-1 deficient patients (3/3) do not reject HLA mismatched BMT; anti LFA-1 blocka in vitro the induction of T cell responses and T/ non T cytotoxic functions; LFA-1 is not expressed by other cells than leucocytes. We have accordingly treated twenty two patients with inherited diseases and 8 with leikemia. The bone marrow was T cells depled by E rosetting of Campath antibody. The antibody was given at days -3, -1, +1, +3, +5 at dose of .1 mg/kg/d for the first 9 and then .2mg/kg/d from day -3 to +6. Engraftment occured in 23/30 patients as shown by at least HLA typing. Hematological recovery was rapid, GVH was limited. Side effects of antibody infusion included fever and possibly an increased incidence of early bacteral infection (sepsis, 1 death). Immunological reconstitution occured slowly leading in six cases to EBV-induced B cell poliferation (1 death and in two others to transient auto immune hemolytic anemia. There has been only one secondary graft rejection. Sisteen patients are alive 3 to 26 months post transplant with functional grafts. Although the number of patients treated is still low the absence of late rejection so far, gives hope for long term maintenance of the graft using anti LFA-1. Since the antibody is an IgG 1 unable to bind human complement, and since it is known to inhibit phagocytosis, there is a good suggestion that 25-3 act through functional blocking of host T and non T luymphocytes at both induction and effector levels.