Relation between DNA damage measured by comet assay and OGG1 Ser326Cys polymorphism in antineoplastic drugs biomonitoring

Antineoplastic drugs are hazardous chemical agents used mostly in the treatment of patients with cancer, however health professionals that handle and administer these drugs can become exposed and develop DNA damage. Comet assay is a standard method for assessing DNA damage in human biomonitoring and, combined with formamidopyrimidine DNA glycosylase (FPG) enzyme, it specifically detects DNA oxidative damage. The aim of this study was to investigate genotoxic effects in workers occupationally exposed to cytostatics (n = 46), as compared to a control group with no exposure (n = 46) at two Portuguese hospitals, by means of the alkaline comet assay. The potential of the OGG1 Ser326Cys polymorphism as a susceptibility biomarker was also investigated. Exposure was evaluated by investigating the contamination of surfaces and genotoxic assessment was done by alkaline comet assay in peripheral blood lymphocytes. OGG1 Ser326Cys (rs1052133) polymorphism was studied by Real Time PCR. As for exposure assessment, there were 121 (37%) positive samples out of a total of 327 samples analysed from both hospitals. No statistically significant differences (Mann-Whitney test, p > 0.05) were found between subjects with and without exposure, regarding DNA damage and oxidative DNA damage, nevertheless the exposed group exhibited higher values. Moreover, there was no consistent trend regarding the variation of both biomarkers as assessed by comet assay with OGG1 polymorphism. Our study was not statistically significant regarding occupational exposure to antineoplastic drugs and genetic damage assessed by comet assay. However, health professionals should be monitored for risk behaviour, in order to ensure that safety measures are applied and protection devices are used correctly.

Interview with Hans G. Hornung

An interview in two sessions, June and July 2014, with Hans Georg Hornung, Clarence L. Johnson Professor of Aeronautics, emeritus, in the Division of Engineering and Applied Science. Dr. Hornung describes the origins of the German Templer Colony in Palestine and his upbringing there before and during World War II. Family moves to Templer settlement, Melbourne, Australia, 1948. He attends technical college; University of Melbourne; master’s in engineering, 1962. Researcher, Aeronautical Research Laboratories, Melbourne; PhD, Imperial College, London, 1965. He recalls his academic career at the Australian National University, Canberra (1967-1980); his interest in hypersonics; building free-piston shock tunnel with Raymond Stalker. Sabbatical in Darmstadt with Ernst Becker. Seven years as director of fluid-mechanics institute of the DLR [Deutsches Zentrum für Luft- und Raumfahrt], in Göttingen. Comes to Caltech in 1987 to succeed Hans W. Liepmann as director of GALCIT [Graduate Aerospace Laboratories, California Institute of Technology]. Recalls his various aero colleagues, his work with Rocketdyne on Caltech’s T5 (successor to Canberra’s T3 shock tunnel) and Ludwieg tube, collaboration with JPL on space program, and work with graduate students Simon Sanderson and Eric Cummings. Discusses his involvement in various scientific societies and his current activities and continuing research as an emeritus professor.

Utilização do mapa espacial de radiação e dose acumulada como ferramenta para otimização de doses em pacientes e trabalhadores nas clínicas de medicina nuclear

This study has as general aim to propose a spatial map of doses as an auxiliary tool in assessing the need for optimization of the workplace in nuclear medicine services. As specific aims, we assessed the workers individual dosimetry; we analyzed the facilities of the nuclear medicine services; and we evaluated environment exposure rates. The research is characterized as a case study, with an exploratory and explanatory nature. It was conducted in three Nuclear Medicine Services, all established in the Northwest of the Paraná State. Results indicated that the evaluated dose rates and workers dosimetry, in all the dependencies of the surveyed services, are within the limits of annual doses. However some exceeded the limits recommended in the standard CNEN-NN 3:01 (2014). It was concluded that the spatial map dose is an important tool for nuclear medicine services because it facilitates the visualization of areas with highest concentration of radiation, and also helps in the constant review of these measures and resources, aiding in the identification of any failures and shortcomings, providing resources to correct any issues and prevent their repetition. The spatial map dose is also important for the regular inspection, evaluating if the radiation protection objectives are being met.

Proper holding temperatures

Proper holding temperatures will ensure that Time/Temperature Control for Safety foods are not in the temperature danger zone (between 45°F and 130°F) while food items are held for further preparation and/or consumption. Hot foods must be maintained at or above 130°F. Cold foods must be maintained at or below 45°F. It also contains a holding temperature log template for use in restaurants.

Las temperaturas adecuadas de conservación

Proper holding temperatures will ensure that Time/Temperature Control for Safety foods are not in the temperature danger zone (between 45°F and 130°F) while food items are held for further preparation and/or consumption. Hot foods must be maintained at or above 130°F. Cold foods must be maintained at or below 45°F. It also contains a holding temperature log template for use in restaurants.

Annual accountability report with Baldrige criteria fiscal year 2005-06

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award..

Annual accountability report with Baldrige criteria fiscal year 2006-07

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award..

Annual accountability report with Baldrige criteria fiscal year 2007-08

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award..

Annual accountability report with Baldrige criteria fiscal year 2008-09

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award.

Annual accountability report with Baldrige criteria fiscal year 2009-10

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award..

Annual accountability report with Baldrige criteria fiscal year 2011-12

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award..

Annual accountability report with Baldrige criteria fiscal year 2012-13

Each year Florence-Darlington Technical College produces an annual accountability report for the South Carolina General Assembly. Included is a mission statement, program description, program goals, major achievements from the past year, goals for the present and future years and criteria associated with the Malcolm Baldridge Award..

2011 – 2012 ACCOUNTABILITY DOCUMENT

2011 – 2012 ACCOUNTABILITY DOCUMENT

2005-2006 state agency accountability report

Orangeburg-Calhoun Technical College reports to the Office of State Budget its annual accountability report that includes a discussion and analysis of major accomplishments, organizational profile, elements of Malcolm Baldridge criteria, strategic planning and performance measurement.

2006-2007 state agency accountability report

Orangeburg-Calhoun Technical College reports to the Office of State Budget its annual accountability report that includes a discussion and analysis of major accomplishments, organizational profile, elements of Malcolm Baldridge criteria, strategic planning and performance measurement.