998 resultados para Tielke, Johann Gottlieb, 1731-87.


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[Geb. 5. Juli 87 Ostrowo; Wohnort: Posen; Staatsangeh.: Preussen; Vorbildung: Auguste-Viktoria-G. Posen Reife 07; Studium: Theol. u. Phil. Halle 3, Lausanne I, Heidelberg 4 S.; Rig. 12. Mai II.]

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Translation of: The life of John Knox.

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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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"Literatur": p. [xi]-xiv.

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Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

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