The journal of Lewis and Clarke to the mouth of the Columbia River beyond the Rocky Mountains in the years 1804-5, & 6 : giving a faithful description of the river Missouri and its source - of the various tribes of Indians through which they passed - manners and customs - soil - climate -commerce - gold and silver mines - animal and vegetable productions, &c.

Mode of access: Internet.

The wrongs of children, or, A practical vindication of children from the injustice done them in early nurture and education : addressed to parents, tutors, guardians, and masters, and to legislators and governors, setting forth the source of much human misery, and pointing out the remedy in a series of essays on education to be published periodically /

Goldsmiths'-Kress no. 22547.

Theology, and not religion, the source of division and strife in the Christian church. A sermon, preached May 14, 1829, at the ordination of Mr. John L. Sibley, as minister of the church in Stow. ...

Printers from p. [2].

A revised translation and interpretation of the sacred scriptures, after the Eastern manner : from current authorities ... shewing that the inspired writings contain the seeds of the valuable sciences, being the source whence the ancient philosophers derived them; also the most ancient histories, and greatest antiquities ... also, the lives and deaths of the apostles.

Preface signed J.M. Ray and dated, London, 1802.

Essays on American silk, and the best means of rendering it a source of individual and national wealth, with directions to farmers for raising silk worms.

Mode of access: Internet.

Tracts on political economy : viz. 1. Britain independent of commerce; 2. Agriculture the source of wealth; 3. The objections against the corn bill refuted; 4. Speech on the East India trade ; with prefatory remarks on the causes and cure of our present distresses, as originating from neglect of principles laid down in these works /

The tracts collected under the above title have individual title-pages. No. 1, 7th ed., 1808; no. 2, 1808; no. 3, 5th ed., 1815; no. 4, speech delivered 1812, no imprint date.

Highway engineering software and source book : a synthesis of software programs available for the Victor 9000 microcomputer.

Mode of access: Internet.

Tephrosia vogelii : a source of rotenoids for insecticidal and piscicidal use /

Caption title.

The mysteries of trade : or, The source of great wealth, containing receipts and patents in chemistry and manufacturing : with practical observations on the useful arts : original and compiled /

Copy inscribed.

The moral state of nations, or Travels over the most interesting part of the globe, to discover the source of moral motion; communicated to lead mankind through the conviction of the senses to intellectual existence, and an enlightened state of nature ... In the year of man's retrospective knowledge, by astrononmical calculation 5000. of the common era, 1790.>

"The revelation of nature: wherein the source of moral motion is disclosed ... [By John Stewart. Granville, Middletown, N. J.] 1835.": 122 p. at end.

Sociology and ethics; the facts of social life as the source of solutions for the theoretical and practical problems of ethics,

Mode of access: Internet.

The continuance of peace and increasing prosperity a source of consolation and just cause of gratitude to the inhabitants of the United States. A sermon, delivered February 19,1795 ; being a day set apart by the President, [for thanksgiving and prayer through the United States.

Evans 29830

American National Standard N433.1 : safe design and use of self-contained, dry source storage gamma irradiators (category I).

Issued July 1978.

Structural basis and prediction of substrate specificity in protein serine/threonine kinases

The large number of protein kinases makes it impractical to determine their specificities and substrates experimentally. Using the available crystal structures, molecular modeling, and sequence analyses of kinases and substrates, we developed a set of rules governing the binding of a heptapeptide substrate motif (surrounding the phosphorylation site) to the kinase and implemented these rules in a web-interfaced program for automated prediction of optimal substrate peptides, taking only the amino acid sequence of a protein kinase as input. We show the utility of the method by analyzing yeast cell cycle control and DNA damage checkpoint pathways. Our method is the only available predictive method generally applicable for identifying possible substrate proteins for protein serine/threonine kinases and helps in silico construction of signaling pathways. The accuracy of prediction is comparable to the accuracy of data from systematic large-scale experimental approaches.

Molecular modelling of human CYP1B1 substrate interactions and investigation of allelic variant effects on metabolism

Molecular modelling of human CYP1B1 based on homology with the mammalian P450, CYP2C5, of known three-dimensional structure is reported. The enzyme model has been used to investigate the likely mode of binding for selected CYP1B1 substrates, particularly with regard to the possible effects of allelic variants of CYP1B1 on metabolism. In general, it appears that the CYP1B1 model is consistent with known substrate selectivity for the enzyme, and the sites of metabolism can be rationalized in terms of specific contacts with key amino acid residues within the CYP1B1 heme locus. Further-more, a mode of binding interaction for the inhibitor, a-naphthoflavone, is presented which accords with currently available information. The current paper shows that a combination of molecular modelling and experimental determinations on the substrate metabolism for CYP1B1 allelic variants can aid in the understanding of structure-function relationships within P450 enzymes. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.