Electron cooling in probe collection from magnetized plasmas with anomalous transport

The electron-retarding range of the current-voltage characteristic of a flat Langmuir probe perpendicular to a strong magnetic field in a fully ionized plasma is analysed allowing for anomalous (Bohm) cross-field transport and temperature changes in the collection process. With probe size and ion thermal gyroradius comparable, and smaller than the electron mean free path, there is an outer quasineutral region with ion viscosity determinant in allowing nonambipolar parallel and cross flow. A potential overshoot lying either at the base or inside the quasineutral region both makes ions follow Boltzmann's law at negative bias and extends the electron-retarding range to probe bias e(j)p ~ +2Too. Electron heating and cooling occur roughly at positive and negative bias, with a re-minimum around efa ~ - 2 7 ^ ; far from the probe heat conduction cools and heats electrons at and radially away from the probe axis, respectively. The potential overshoot with no thermal effects would reduce the electron current Ie, making the In Ie versus 4>p graph downwards-concave,but cooling further reduces Ie substantially, and may tilt the slope upwards past the temperature minimum. The domain of strict validity of our analysis is narrow in case of low ion mass (deuterium), breaking down with the ion Boltzmann law.

Desarrollo de un entorno inteligente en el contexto del hogar digital

A lo largo de las últimas décadas el desarrollo de la tecnología en muy distintas áreas ha sido vertiginoso. Su propagación a todos los aspectos de nuestro día a día parece casi inevitable y la electrónica de consumo ha invadido nuestros hogares. No obstante, parece que la domótica no ha alcanzado el grado de integración que cabía esperar hace apenas una década. Es cierto que los dispositivos autónomos y con un cierto grado de inteligencia están abriéndose paso de manera independiente, pero el hogar digital, como sistema capaz de abarcar y automatizar grandes conjuntos de elementos de una vivienda (gestión energética, seguridad, bienestar, etc.) no ha conseguido extenderse al hogar medio. Esta falta de integración no se debe a la ausencia de tecnología, ni mucho menos, y numerosos son los estudios y proyectos surgidos en esta dirección. Sin embargo, no ha sido hasta hace unos pocos años que las instituciones y grandes compañías han comenzado a prestar verdadero interés en este campo. Parece que estamos a punto de experimentar un nuevo cambio en nuestra forma de vida, concretamente en la manera en la que interactuamos con nuestro hogar y las comodidades e información que este nos puede proporcionar. En esa corriente se desarrolla este Proyecto Fin de Grado, con el objetivo de aportar un nuevo enfoque a la manera de integrar los diferentes dispositivos del hogar digital con la inteligencia artificial y, lo que es más importante, al modo en el que el usuario interactúa con su vivienda. Más concretamente, se pretende desarrollar un sistema capaz de tomar decisiones acordes al contexto y a las preferencias del usuario. A través de la utilización de diferentes tecnologías se dotará al hogar digital de cierta autonomía a la hora de decidir qué acciones debe llevar a cabo sobre los dispositivos que contiene, todo ello mediante la interpretación de órdenes procedentes del usuario (expresadas de manera coloquial) y el estudio del contexto que envuelve al instante de ejecución. Para la interacción entre el usuario y el hogar digital se desarrollará una aplicación móvil mediante la cual podrá expresar (de manera conversacional) las órdenes que quiera dar al sistema, el cual intervendrá en la conversación y llevará a cabo las acciones oportunas. Para todo ello, el sistema hará principalmente uso de ontologías, análisis semántico, redes bayesianas, UPnP y Android. Se combinará información procedente del usuario, de los sensores y de fuentes externas para determinar, a través de las citadas tecnologías, cuál es la operación que debe realizarse para satisfacer las necesidades del usuario. En definitiva, el objetivo final de este proyecto es diseñar e implementar un sistema innovador que se salga de la corriente actual de interacción mediante botones, menús y formularios a los que estamos tan acostumbrados, y que permita al usuario, en cierto modo, hablar con su vivienda y expresarle sus necesidades, haciendo a la tecnología un poco más transparente y cercana y aproximándonos un poco más a ese concepto de hogar inteligente que imaginábamos a finales del siglo XX. ABSTRACT. Over the last decades the development of technology in very different areas has happened incredibly fast. Its propagation to all aspects of our daily activities seems to be inevitable and the electronic devices have invaded our homes. Nevertheless, home automation has not reached the integration point that it was supposed to just a few decades ago. It is true that some autonomic and relatively intelligent devices are emerging, but the digital home as a system able to control a large set of elements from a house (energy management, security, welfare, etc.) is not present yet in the average home. That lack of integration is not due to the absence of technology and, in fact, there are a lot of investigations and projects focused on this field. However, the institutions and big companies have not shown enough interest in home automation until just a few years ago. It seems that, finally, we are about to experiment another change in our lifestyle and how we interact with our home and the information and facilities it can provide. This Final Degree Project is developed as part of this trend, with the goal of providing a new approach to the way the system could integrate the home devices with the artificial intelligence and, mainly, to the way the user interacts with his house. More specifically, this project aims to develop a system able to make decisions, taking into account the context and the user preferences. Through the use of several technologies and approaches, the system will be able to decide which actions it should perform based on the order interpretation (expressed colloquially) and the context analysis. A mobile application will be developed to enable the user-home interaction. The user will be able to express his orders colloquially though out a conversational mode, and the system will also participate in the conversation, performing the required actions. For providing all this features, the system will mainly use ontologies, semantic analysis, Bayesian networks, UPnP and Android. Information from the user, the sensors and external sources will be combined to determine, through the use of these technologies, which is the operation that the system should perform to meet the needs of the user. In short, the final goal of this project is to design and implement an innovative system, away from the current trend of buttons, menus and forms. In a way, the user will be able to talk to his home and express his needs, experiencing a technology closer to the people and getting a little closer to that concept of digital home that we imagined in the late twentieth century.

3D simulation of complex shading affecting PV systems taking benefit from the power of graphics cards developed for the video game industry

Shading reduces the power output of a photovoltaic (PV) system. The design engineering of PV systems requires modeling and evaluating shading losses. Some PV systems are affected by complex shading scenes whose resulting PV energy losses are very difficult to evaluate with current modeling tools. Several specialized PV design and simulation software include the possibility to evaluate shading losses. They generally possess a Graphical User Interface (GUI) through which the user can draw a 3D shading scene, and then evaluate its corresponding PV energy losses. The complexity of the objects that these tools can handle is relatively limited. We have created a software solution, 3DPV, which allows evaluating the energy losses induced by complex 3D scenes on PV generators. The 3D objects can be imported from specialized 3D modeling software or from a 3D object library. The shadows cast by this 3D scene on the PV generator are then directly evaluated from the Graphics Processing Unit (GPU). Thanks to the recent development of GPUs for the video game industry, the shadows can be evaluated with a very high spatial resolution that reaches well beyond the PV cell level, in very short calculation times. A PV simulation model then translates the geometrical shading into PV energy output losses. 3DPV has been implemented using WebGL, which allows it to run directly from a Web browser, without requiring any local installation from the user. This also allows taken full benefits from the information already available from Internet, such as the 3D object libraries. This contribution describes, step by step, the method that allows 3DPV to evaluate the PV energy losses caused by complex shading. We then illustrate the results of this methodology to several application cases that are encountered in the world of PV systems design. Keywords: 3D, modeling, simulation, GPU, shading, losses, shadow mapping, solar, photovoltaic, PV, WebGL

Occupational allergic multiorgan disease induced by wheat flour

Bakers are repeatedly exposed to wheat flour (WF) and may develop sensitization and occupational rhinoconjunctivitis and/or asthma to WF allergens.1 Several wheat proteins have been identified as causative allergens of occupational respiratory allergy in bakery workers.1 Testing of IgE reactivity in patients with different clinical profiles of wheat allergy (food allergy, wheat-dependent exercise-induced anaphylaxis, and baker's asthma) to salt-soluble and salt-insoluble protein fractions from WF revealed a high degree of heterogeneity in the recognized allergens. However, mainly salt-soluble proteins (albumins, globulins) seem to be associated with baker's asthma, and prolamins (gliadins, glutenins) with wheat-dependent exercise-induced anaphylaxis, whereas both protein fractions reacted to IgE from food-allergic patients.1 Notwithstanding, gliadins have also been incriminated as causative allergens in baker's asthma.2 We report on a 31-year-old woman who had been exposed to WF practically since birth because her family owned a bakery housed in the same home where they lived. She moved from this house when she was 25 years, but she continued working every day in the family bakery. In the last 8 years she had suffered from work-related nasal and ocular symptoms such as itching, watery eyes, sneezing, nasal stuffiness, and rhinorrhea. These symptoms markedly improved when away from work and worsened at work. In the last 5 years, she had also experienced dysphagia with frequent choking, especially when ingesting meats or cephalopods, which had partially improved with omeprazole therapy. Two years before referral to our clinic, she began to have dry cough and breathlessness, which she also attributed to her work environment. Upper and lower respiratory tract symptoms increased when sifting the WF and making the dough. The patient did not experience gastrointestinal symptoms with ingestion of cereal products. Skin prick test results were positive to grass (mean wheal, 6 mm), cypress (5 mm) and Russian thistle pollen (4 mm), WF (4 mm), and peach lipid transfer protein (6 mm) and were negative to rice flour, corn flour, profilin, mites, molds, and animal dander. Skin prick test with a homemade WF extract (10% wt/vol) was strongly positive (15 mm). Serologic tests yielded the following results: eosinophil cationic protein, 47 ?g/L; total serum IgE, 74 kU/L; specific IgE (ImmunoCAP; ThermoFisher, Uppsala, Sweden) to WF, 7.4 kU/L; barley flour, 1.24 kU/L; and corn, gluten, alpha-amylase, peach, and apple, less than 0.35 kU/L. Specific IgE binding to microarrayed purified WF allergens (WDAI-0.19, WDAI-0.53, WTAI-CM1, WTAI-CM2, WTAI-CM3, WTAI-CM16, WTAI-CM17, Tri a 14, profilin, ?-5-gliadin, Tri a Bd 36 and Tri a TLP, and gliadin and glutamine fractions) was assessed as described elsewhere.3 The patient's serum specifically recognized ?-5-gliadin and the gliadin fraction, and no IgE reactivity was observed to other wheat allergens. Spirometry revealed a forced vital capacity of 3.88 L (88%), an FEV1 of 3.04 L (87%), and FEV1/forced vital capacity of 83%. A methacholine inhalation test was performed following an abbreviated protocol,4 and the results were expressed as PD20 in cumulative dose (mg) of methacholine. Methacholine inhalation challenge test result was positive (0.24 mg cumulative dose) when she was working, and after a 3-month period away from work and with no visits to the bakery house, it gave a negative result. A chest x-ray was normal. Specific inhalation challenge test was carried out in the hospital laboratory by tipping WF from one tray to another for 15 minutes. Spirometry was performed at baseline and at 2, 5, 10, 15, 20, 30, 45, and 60 minutes after the challenge with WF. Peak expiratory flow was measured at baseline and then hourly over 24 hours (respecting sleeping time). A 12% fall in FEV1 was observed at 20 minutes and a 26% drop in peak expiratory flow at 9 hours after exposure to WF,

2. 6 Memorial for Lloyd Gaines, St. Peter's Cemetery, Normandy, St. Louis County, Missouri

What happened to Gaines? There are many ideas ranging from being murdered or lynched, being bribed to run away, or disappearing on his own to get away from the pressure of celebrity. That final possibility was brought about by Dr. Greene, who claimed that a man who sounded like Gaines had phoned him while in Mexico and wished to meet. The man never showed up. A recent theory is one of where Lloyd was kidnapped by opponents of the Gaines court decision who took him to Jefferson City and lynched him in McClung Park. All of these theories are speculation and the fact remains that Lloyd Gaines’ whereabouts are a mystery to this day.

Microtubule release from the centrosome

Although microtubules (MTs) are generally thought to originate at the centrosome, a number of cell types have significant populations of MTs with no apparent centrosomal connection. The origin of these noncentrosomal MTs has been unclear. We applied kinetic analysis of MT formation in vivo to establish their mode of origin. Time-lapse fluorescence microscopy demonstrated that noncentrosomal MTs in cultured epithelial cells arise primarily by constitutive nucleation at, and release from, the centrosome. After release, MTs moved away from the centrosome and tended to depolymerize. Laser-marking experiments demonstrated that released MTs moved individually with their plus ends leading, suggesting that they were transported by minus end-directed motors. Released MTs were dynamic. The laser marking experiments demonstrated that plus ends of released MTs grew, paused, or shortened while the minus ends were stable or shortened. Microtubule release may serve two kinds of cellular function. Release and transport could generate the noncentrosomal MT arrays observed in epithelial cells, neurons, and other asymmetric, differentiated cells. Release would also contribute to polymer turnover by exposing MT minus ends, thereby providing additional sites for loss of subunits. The noncentrosomal population of MTs may reflect a steady-state of centrosomal nucleation, release, and dynamics.

Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena

Unilateral intrahippocampal injections of tetrodotoxin were used to temporarily inactivate one hippocampus during specific phases of training in an active allothetic place avoidance task. The rat was required to use landmarks in the room to avoid a room-defined sector of a slowly rotating circular arena. The continuous rotation dissociated room cues from arena cues and moved the arena surface through a part of the room in which foot-shock was delivered. The rat had to move away from the shock zone to prevent being transported there by the rotation. Unilateral hippocampal inactivations profoundly impaired acquisition and retrieval of the allothetic place avoidance. Posttraining unilateral hippocampal inactivation also impaired performance in subsequent sessions. This allothetic place avoidance task seems more sensitive to hippocampal disruption than the standard water maze task because the same unilateral hippocampal inactivation does not impair performance of the variable-start, fixed hidden goal task after procedural training. The results suggest that the hippocampus not only encodes allothetic relationships amongst landmarks, it also organizes perceived allothetic stimuli into systems of mutually stable coordinates. The latter function apparently requires greater hippocampal integrity.

Free energy reconstruction from nonequilibrium single-molecule pulling experiments

Laser tweezers and atomic force microscopes are increasingly used to probe the interactions and mechanical properties of individual molecules. Unfortunately, using such time-dependent perturbations to force rare molecular events also drives the system away from equilibrium. Nevertheless, we show how equilibrium free energy profiles can be extracted rigorously from repeated nonequilibrium force measurements on the basis of an extension of Jarzynski's remarkable identity between free energies and the irreversible work.

Ultrafast diffraction and structural dynamics: The nature of complex molecules far from equilibrium

Studies of molecular structures at or near their equilibrium configurations have long provided information on their geometry in terms of bond distances and angles. Far-from-equilibrium structures are relatively unknown—especially for complex systems—and generally, neither their dynamics nor their average geometries can be extrapolated from equilibrium values. For such nonequilibrium structures, vibrational amplitudes and bond distances play a central role in phenomena such as energy redistribution and chemical reactivity. Ultrafast electron diffraction, which was developed to study transient molecular structures, provides a direct method for probing the nature of complex molecules far from equilibrium. Here we present our ultrafast electron diffraction observations of transient structures for two cyclic hydrocarbons. At high internal energies of ≈4 eV, these molecules display markedly different behavior. For 1,3,5-cycloheptatriene, excitation results in the formation of hot ground-state structures with bond distances similar to those of the initial structure, but with nearly three times the average vibrational amplitude. Energy is redistributed within 5 ps, but with a negative temperature characterizing the nonequilibrium population. In contrast, the ring-opening reaction of 1,3-cyclohexadiene is shown to result in hot structures with a C—C bond distance of over 1.7 Å, which is 0.2 Å away from any expected equilibrium value. Even up to 400 ps, energy remains trapped in large-amplitude motions comprised of torsion and asymmetric stretching. These studies promise a new direction for studying structural dynamics in nonequilibrium complex systems.

Fluidity of the lipid domain of cell wall from Mycobacterium chelonae.

The mycobacterial cell wall contains large amounts of unusual lipids, including mycolic acids that are covalently linked to the underlying arabinogalactan-peptidoglycan complex. Hydrocarbon chains of much of these lipids have been shown to be packed in a direction perpendicular to the plane of the cell surface. In this study, we examined the dynamic properties of the organized lipid domains in the cell wall isolated from Mycobacterium chelonae grown at 30 degrees C. Differential scanning calorimetry showed that much of the lipids underwent major thermal transitions between 30 degree C and 65 degrees C, that is at temperatures above the growth temperature, a result suggesting that a significant portion of the lipids existed in a structure of extremely low fluidity in the growing cells. Spin-labeled fatty acid probes were successfully inserted into the more fluid part of the cell wall. Our model of the cell wall suggests that this domain corresponds to the outermost leaflet, a conclusion reinforced by the observation that labeling of intact cells produced electron spin resonance spectra similar to those of the isolated cell wall. Use of stearate labeled at different positions showed that the fluidity within the outer leaflet increased only slightly as the nitroxide group was placed farther away from the surface. These results are consistent with the model of mycobacterial cell wall containing an asymmetric lipid bilayer, with an internal, less fluid mycolic acid leaflet and an external, more fluid leaflet composed of lipids containing shorter chain fatty acids. The presence of the low-fluidity layer will lower the permeability of the cell wall to lipophilic antibiotics and chemotherapeutic agents and may contribute to the well-known intrinsic resistance of mycobacteria to such compounds.

Vivir con Chagas en Madrid: estructuras temporales de la vivencia de un grupo de pacientes bolivianos con el diagnóstico y la atención médica a la enfermedad de Chagas en un hospital metropolitano español

How can a chronic disease determine the life of a group of people diagnosed as seropositive away from their home country? And how do we account for that lived experience. Some diseases contemplated a few decades ago as strictly rural or of poor countries, are an urban reality now and are part of the epidemiological setting in wealthy developed countries. That is the case of Chagas disease in Spain. A disease linked for a long time to rural poverty, until migratory movements occurred nationwide from the country side to the city, and recently with international migration have turned pathology into a global public health issue. Chagas disease is a chronic parasitic infection, endemic in all Latin America and can be transmitted by triatomine or “kissing bug” (Triatoma Infestans), which lives and reproduces in straw houses of rural regions. According to the Pan American Health Organization (PAHO, 2006), the disease affects approximately eight million people. It is recognized by the WHO as a “neglected tropical disease”...

Employee Leadership Development

Abstract \ The business importance of retaining and developing top performing employees is more crucial to business organizations that in the past, yet many organizations are not confident in their ability to staff leadership positions within the next five years. Many companies continue to run without a employee leadership development program. Organizations that shy away from development programs tend to do so because of fear the costs are too high. Organizations that support leadership programs acknowledge that the benefits far outweigh the costs. In this capstone study, the researcher illustrates that employee leadership development programs add value through improved business strategy and employee satisfaction, and as a result, represent a worthy investment.

Letter from Samuel Willard, Lancaster, Massachusetts to Catherine Willard, Petersham, Massachusetts, June 18, 1799

Willard asks his sister to bring some of his clothes to a tailor, and also to make him a pair of linen gloves, and to send him various items from home, including books, a jacket, and a hat.

Russia and Turkey - What does their partnership mean for the EU? EPC Policy Brief, 13 February 2015

Russia and Turkey have, over the past two decades, developed a very constructive relationship across a wide variety of policy areas. Imperial rivals during much of the Cold War, both countries have since then found common interests in matters of energy, trade and even defence. Besides their growing interdependence, it is hard not to notice the similarities between the two leaders of these countries, especially when it comes to the conspiracy mind-set of blaming dissent at home on foreign meddling. But does this mean that Turkey is fundamentally realigning its foreign policy strategy, away from the EU and towards Russia? And is the EU facing the emergence of an “axis of the excluded”? Not so according to Dimitar Bechev. In this Policy Brief, he argues that the ties between Russia and Turkey are driven by pragmatism and realpolitik. Contentious issues – such as the war in Syria - may be insulated from areas of overlapping interest, but deeper examination shows the glue holding the two countries together – their energy interdependence – is slowly weakening. Bechev believes the EU should take advantage of this divergence and try to (re-)anchor Turkey to its own initiatives and policies.

U.S. Democracy Promotion from Bush to Obama. EUSpring Working Paper No. 1, April 2015

Throughout the twenty-first century the United States (U.S.) has attempted to balance its traditional national security interests, whilst also seeking to promote the long-term transformation of the Middle East and North Africa (MENA) towards democracy based on liberal values. With the September 11, 2001 terrorist attacks providing a catalyst for policy change, the U.S. has moved away from its twentieth-century policy of pursuing a regional status quo and instinctively balking at political change. Yet, the U.S. has not abandoned its reliance on autocratic regimes that cooperate on more immediate national security interests such as counter-terrorism, counter-proliferation, and the free-flow energy sources into the global market. Rather, U.S. democracy promotion in the MENA has become incremental by design and is characterized by its gradualist and often collaborative nature. U.S. foreign policy in the MENA is, therefore, depicted by a cautious evolutionary stance rather than supporting revolutionary shifts in power.