The Art of disappearing

Poem

Studio portrait of Elfriede Maria Roth; Cambridge, Massachusetts Portraits; Children

When Bruno Roth arrived in the United States in 1939 he opened a photo studio. He used this photograph for advertising

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Signed portrait of Maria Leschnitzer.

Wife of Adolf Leschnitzer

Dr. Rainer Erb at the ZFA (Zentrum für Antisemitismusforschung; Center for Research on Antisemitism); Berlin Portraits Men

Digital Image

Passport portrait of Maria Leschnitzer.

Wife of Adolf Leschnitzer