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In southern Bahia, Brazil, large land areas are used for the production of cocoa (Theobroma cacao), which is predominantly grown under the shade of native trees in an agroforestry system locally known as cabruca. As a dominant forest-like landscape element of the cocoa region, the cabrucas play an important role in the conservation of the region`s biodiversity. The purpose of this review is to provide the scientific basis for an action plan to reconcile cocoa production and biodiversity conservation in southern Bahia. The available research collectively highlights the diversity of responses of different species and biological groups to both the habitat quality of the cabrucas themselves and to the general characteristics of the landscape, such as the relative extent and spatial configuration of different vegetation types within the landscape mosaic. We identify factors that influence directly or indirectly the occurrence of native species in the cabrucas and the wider landscape of the cocoa region and develop recommendations for their conservation management. We show that the current scientific knowledge already provides a good basis for a biodiversity friendly management of the cocoa region of southern Bahia, although more work is needed to refine some management recommendations, especially on shade canopy composition and density, and verify their economic viability. The implementation of our recommendations should be accompanied by appropriate biological and socioeconomic monitoring and the findings should inform a broad program of adaptive management of the cabrucas and the wider cocoa landscape.

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Carpenter syndrome, a rare autosomal recessive disorder characterized by a combination of craniosynostosis, polysyndactyly, obesity, and other congenital malformations, is caused by mutations in RAB23, encoding a member of the Rab-family of small GTPases. In 15 out of 16 families previously reported, the disease was caused by homozygosity for truncating mutations, and currently only a single missense mutation has been identified in a compound heterozygote. Here, we describe a further 8 independent families comprising 10 affected individuals with Carpenter syndrome, who were positive for mutations in RAB23. We report the first homozygous missense mutation and in-frame deletion, highlighting key residues for RAB23 function, as well as the first splice-site mutation. Multi-suture craniosynostosis and polysyndactyly have been present in all patients described to date, and abnormal external genitalia have been universal in boys. High birth weight was not evident in the current group of patients, but further evidence for laterality defects is reported. No genotype-phenotype correlations are apparent. We provide experimental evidence that transcripts encoding truncating mutations are subject to nonsense-mediated decay, and that this plays an important role in the pathogenesis of many RAB23 mutations. These observations refine the phenotypic spectrum of Carpenter syndrome and offer new insights into molecular pathogenesis. (C) 2011 Wiley-Liss, Inc.

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The relationship between thought and language and, in particular, the issue of whether and how language influences thought is still a matter of fierce debate. Here we consider a discrimination task scenario to study language acquisition in which an agent receives linguistic input from an external teacher, in addition to sensory stimuli from the objects that exemplify the overlapping categories that make up the environment. Sensory and linguistic input signals are fused using the Neural Modelling Fields (NMF) categorization algorithm. We find that the agent with language is capable of differentiating object features that it could not distinguish without language. In this sense, the linguistic stimuli prompt the agent to redefine and refine the discrimination capacity of its sensory channels. (C) 2007 Elsevier Ltd. All rights reserved.

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Background: Linkage mapping is used to identify genomic regions affecting the expression of complex traits. However, when experimental crosses such as F2 populations or backcrosses are used to map regions containing a Quantitative Trait Locus (QTL), the size of the regions identified remains quite large, i.e. 10 or more Mb. Thus, other experimental strategies are needed to refine the QTL locations. Advanced Intercross Lines (AIL) are produced by repeated intercrossing of F2 animals and successive generations, which decrease linkage disequilibrium in a controlled manner. Although this approach is seen as promising, both to replicate QTL analyses and fine-map QTL, only a few AIL datasets, all originating from inbred founders, have been reported in the literature. Methods: We have produced a nine-generation AIL pedigree (n = 1529) from two outbred chicken lines divergently selected for body weight at eight weeks of age. All animals were weighed at eight weeks of age and genotyped for SNP located in nine genomic regions where significant or suggestive QTL had previously been detected in the F2 population. In parallel, we have developed a novel strategy to analyse the data that uses both genotype and pedigree information of all AIL individuals to replicate the detection of and fine-map QTL affecting juvenile body weight. Results: Five of the nine QTL detected with the original F2 population were confirmed and fine-mapped with the AIL, while for the remaining four, only suggestive evidence of their existence was obtained. All original QTL were confirmed as a single locus, except for one, which split into two linked QTL. Conclusions: Our results indicate that many of the QTL, which are genome-wide significant or suggestive in the analyses of large intercross populations, are true effects that can be replicated and fine-mapped using AIL. Key factors for success are the use of large populations and powerful statistical tools. Moreover, we believe that the statistical methods we have developed to efficiently study outbred AIL populations will increase the number of organisms for which in-depth complex traits can be analyzed.

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A crucial aspect of evidential reasoning in crime investigation involves comparing the support that evidence provides for alternative hypotheses. Recent work in forensic statistics has shown how Bayesian Networks (BNs) can be employed for this purpose. However, the specification of BNs requires conditional probability tables describing the uncertain processes under evaluation. When these processes are poorly understood, it is necessary to rely on subjective probabilities provided by experts. Accurate probabilities of this type are normally hard to acquire from experts. Recent work in qualitative reasoning has developed methods to perform probabilistic reasoning using coarser representations. However, the latter types of approaches are too imprecise to compare the likelihood of alternative hypotheses. This paper examines this shortcoming of the qualitative approaches when applied to the aforementioned problem, and identifies and integrates techniques to refine them.

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A crucial aspect of evidential reasoning in crime investigation involves comparing the support that evidence provides for alternative hypotheses. Recent work in forensic statistics has shown how Bayesian Networks (BNs) can be employed for this purpose. However, the specification of BNs requires conditional probability tables describing the uncertain processes under evaluation. When these processes are poorly understood, it is necessary to rely on subjective probabilities provided by experts. Accurate probabilities of this type are normally hard to acquire from experts. Recent work in qualitative reasoning has developed methods to perform probabilistic reasoning using coarser representations. However, the latter types of approaches are too imprecise to compare the likelihood of alternative hypotheses. This paper examines this shortcoming of the qualitative approaches when applied to the aforementioned problem, and identifies and integrates techniques to refine them.

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The specification of Quality of Service (QoS) constraints over software design requires measures that ensure such requirements are met by the delivered product. Achieving this goal is non-trivial, as it involves, at least, identifying how QoS constraint specifications should be checked at the runtime. In this paper we present an implementation of a Model Driven Architecture (MDA) based framework for the runtime monitoring of QoS properties. We incorporate the UML2 superstructure and the UML profile for Quality of Service to provide abstract descriptions of component-and-connector systems. We then define transformations that refine the UML2 models to conform with the Distributed Management Taskforce (DMTF) Common Information Model (CIM) (Distributed Management Task Force Inc. 2006), a schema standard for management and instrumentation of hardware and software. Finally, we provide a mapping the CIM metamodel to a .NET-based metamodel for implementation of the monitoring infrastructure utilising various .NET features including the Windows Management Instrumentation (WMI) interface.

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Esta tese procura discutir a atualidade do paternalismo enquanto traço cultural das organizações brasileiras. Resgatando as raízes culturais brasileiras e apoiando-se em trabalhos de fundamentação antropológica, sociológica e psicanalítica, estabelece uma hipótese central de que o paternalismo possa ser encontrado hoje, no Brasil, tanto em empresas pequenas, onde predomina o controle de tipo paterno, quanto em empresas maiores e mais complexas, com tendência ao desenvolvimento de um sistema de controle de tipo materno, onde o paternalismo daria origem a uma versão abrasileirada deste. Pesquisa de campo de cunho etnográfico, realizada em três empresas de portes distintos do Pólo Têxtil de Americana-SP, mostrou indícios favoráveis à hipótese central, apresentando, todavia, importantes peculiaridades que, ao passo que permitem refiná-la, indicam trilhas para novos estudos. Na empresa de menor porte e complexidade, o paternalismo mostrou-se da maneira mais conhecida, nas práticas ora carinhosas, ora severas dos diretores da empresa. Nas empresas mais complexas, pudemos notar a expressão da ação dos pais que regulam o gozo dos filhos. A face protetora e a face violenta se revelam na medida em que se dá ou se restringe acesso ao amor da mãe. Nos três casos estudados, o paternalismo aparece com sua face afetiva predominado significativamente em relação à face violenta, o que parece ser elemento associado ao sucesso experimentado por tais empresas.

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Essa tese tem como objetivo contribuir para a compreensão da ocorrência de práticas associadas ao intra-empreendedorismo em organizações não-governamentais (ONGs). Elaborou-se um referencial de análise preliminar a partir da revisão bibliográfica sobre os conceitos de intra-empreendedorismo, organizações não-governamentais e teoria institucional. Esse arcabouço teórico orientou a realização de pesquisa empírica, qualitativa e de natureza exploratória, empreendida por meio de estudo de caso, tendo como objeto de estudo organizações não-governamentais. Foram realizados dois estudos de casos. O primeiro analisou uma ONG localizada na cidade do Rio de Janeiro, cujo foco principal de atuação é a área da saúde, e que emprega o trabalho voluntário de forma intensiva. O segundo estudo de caso foi voltado à análise de uma ONG localizada na cidade de São Paulo, cujo foco principal de atuação é a educação, que desenvolve suas atividades valendo-se basicamente de trabalho remunerado, e que se enquadra na categoria de Organização da Sociedade Civil de Interesse Público - OSCIP. Com os estudos de casos, foi possível obter subsídios para analisar e refinar o referencial previamente elaborado. São levantadas, também, considerações referentes à adoção de práticas associadas ao intra-empreendedorismo e ao discurso empreendedor legitimador das organizações não-governamentais.

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Araujo, Páscoa and Torres-Martínez (2002) showed that, without imposing any debt constraint, Ponzi schemes are ruled out in infinite horizon economies with limited commitment when collateral is the only mechanism that partially secures loans. Páscoa and Seghir (2009) presented two examples in which they argued that Ponzi schemes may reappear if, additionally to the seizure of the collateral, there are sufficiently harsh default penalties assessed (directly in terms of utility) against the defaulters. Moreover, they claimed that if default penalties are moderate then Ponzi schemes are ruled out and existence of a competitive equilibrium is restored. This paper questions the validity of the claims made in Páscoa and Seghir (2009). First, we show that it is not true that harsh default penalties lead to Ponzi schemes in the examples they have proposed. A competitive equilibrium with no trade can be supported due to unduly pessimistic expectations on asset deliveries. We subsequently refine the equilibrium concept in the spirit of Dubey, Geanakoplos and Shubik (2005) in order to rule out spurious inactivity on asset markets due to irrational expectations. Our second contribution is to provide a specific example of an economy with moderate default penalties in which Ponzi schemes reappear when overpessimistic beliefs on asset deliveries are ruled out. Our finding shows that, contrary to what is claimed by Páscoa and Seghir (2009), moderate default penalties do not always prevent agents to run a Ponzi scheme.

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Argumentando-se que as Tecnologias da Informação Móveis e Sem Fio (TIMS) vêm ocupando um espaço, cada vez maior, na vida dos indivíduos, e que, em função desta proximidade, novas formas de interação aparecem, este trabalho procurou aprofundar a relação entre Smartphones e Gênero. Fundamentado em abordagens teóricas relativas à existência de paradoxos associados ao uso de artefatos tecnológicos e às copying strategies adotadas pelos usuários, este estudo procurou identificar a existência e a intensidade de paradoxos associados ao uso diário de smartphones por executivos brasileiros, de ambos os sexos. O trabalho também procurou avaliar a forma como os executivos lidam com as possíveis ambiguidades vivenciadas em seus dia-a-dia. O método de estudo de caso múltiplo, cujos executivos eram as unidades de análise, foi aplicado junto a executivos mulheres e homens, usuários constantes da tecnologia smartphone e ocupantes de cargos de médio e alto escalão em grandes empresas brasileiras. A partir de um método de coleta misto – questionários, diários de uso e entrevistas em profundidade –, o trabalho teve o objetivo de aprofundar e refinar os estudos sobre paradoxos tecnológicos, bem como iniciar análises quanto à relação do gênero e esses mesmos paradoxos. Após a consolidação e análise dos dados obtidos, verificou-se que apenas parte dos 14 paradoxos tecnológicos apresentados por Mick e Fournier (1998), Jarvenppa e Lang (2005) e Mazmanin et al. (2006) foram associados à interação entre executivos e smartphones. Dos 6 paradoxos identificados, 2 foram exclusivamente relacionados às mulheres, sugerindo que as executivas percebem e vivenciam os paradoxos com mais intensidade do que seus pares masculinos. Os dados também revelaram que diantes das ambiguidades, os executivos mulheres e homens procuram adotar estratégias de enfrentamento, tentando desenvolver um relacionamento positivo e de parceria com seus artefatos. Ao final, as conclusões e implicações deste estudo são detalhadamente apresentadas.

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Empirical evidence shows that larger firms pay higher wages than smaller ones. This wage premium is called the firm size wage effect. The firm size effect on wages may be attributed to many factors, as differentials on productivity, efficiency wage, to prevent union formation, or rent sharing. The present study uses quantile regression to investigate the finn size wage effect. By offering insight into who benefits from the wage premi um, quantile regression helps eliminate and refine possible explanations. Estimated results are consistent with the hypothesis that the higher wages paid by large firms can be explained by the difference in monitoring costs that large firms face. Results also suggest that more highly skilled workers are more often found at larger firms .

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Seguindo a tendência mundial de um melhor gerenciamento de riscos, o regulador do mercado de seguros brasileiro, após a implementação dos demais riscos, está em fase avançada de desenvolvimento de seu modelo para aferir o risco de mercado das seguradoras. Uma vez que as discussões cessem, as empresas serão forçadas a usar um modelo que, hoje, apresenta muitas falhas, gerando uma demanda de capital adicional de seus acionistas que pode levar algumas delas ao estado de insolvência. O principal objetivo deste estudo é analisar a adequação do modelo e subsidiar a discussão a fim de aperfeiçoar o modelo final, com análises comparativas com outros modelos no país e no mundo, estudo de cenários e visões do mercado. De modo geral, as análises feitas revelam problemas sérios no modelo, como necessidade de aporte de capital em empresas extremamente lucrativas e insuficiência de garantia de segurança pelo uso puro dos fatores de choque em detrimento a uma análise estocástica. Finalmente, são sugeridas algumas soluções para minimizar o efeito da inadequação do modelo e ainda algumas sugestões para melhoria do mesmo, de forma que os acionistas não sejam prejudicados, o regulador consiga administrar adequadamente os riscos e a sociedade seja beneficiada pela solidez das companhias em quem confiou seus riscos.

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A pesquisa tem como objetivo avaliar a relação dos movimentos sociais de junho de 2013 com a Câmara Municipal do Rio de Janeiro, quando da ruptura dos diálogos e a ocupação desta em dois momentos distintos: a discussão e votação do plano de cargos, carreiras e salários dos professores da rede pública municipal, e a composição e instalação da Comissão Parlamentar de Inquérito dos ônibus. Para tanto, foram criadas 5 categorias de análise: 1. Política e Participação; 2. Manifestações, Mobilizações e Movimentos; 3. Ocupa Câmara; 4. CPI dos Ônibus e Plano de Cargos e Salários dos Professores; 5. Diálogos. O trabalho também apresenta recomendações que visam a elaboração de um plano de trabalho para o exercício de mandato parlamentar que aperfeiçoe os mecanismos de participação, transparência, democracia direta e interativa na Câmara Municipal do Rio de Janeiro e, desta forma, conecte.

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The public management reform in Brazil, since 1995, provoked new experiences in public administration. Among the new models of public service the one-stop shopping has distinguished and was adopted at Rio Grande do Norte with the Citizens Center Program. The one-stop shopping assembles in the same place many public services with appropriate structure, enabled human resources and citizens focus processes. The goal of this research was understand how citizens focus processes help to explain Citizens Center Program s longevity. It was made a case study and the research tools were applied with Citizen Center Programs workers and citizen-users at South Unit of Citizen Center Program placed at Via Direta Mall, Natal. The major contributions for Citizen Center Program s longevity were imputed to Basic Operation Processes. The most spoken features in Citizen Center Program mentioned were quality, efficiency, celerity e personal appearance, what demonstrate concern and care with citizen-users. Worker s personal appearance, accommodation, celerity, politeness and attending capacity planning were high evaluated by citizen-users revealing the wisely choice of use a large quality concept and citizenship concept in public administration. Citizen-users also pointed the necessity of refine and enlarge the communication ways that form an essential mechanism to public citizen focus administration. Not ignoring the policy aspect citizen focus processes were noticed like especial management actions that make easier citizen s activities and public service access, what generate satisfaction to citizen-users. It s possible to conclude that the high level approving evaluation of Citizen Center Program consolidates it an especial public policy that serves citizen s necessities e create appropriate legitimacy conditions of the public policy making harder the choice of ending the policy even in more fragile moments strongly contributing for its longevity