Curcumina: de especiaria à nutracêutico

A ideia de uma nutrição que, além de suprir as necessidades nutricionais básicas do organismo também tem como objetivo a prevenção de doenças, ganha cada vez mais ênfase sobre a égide dos alimentos funcionais e dos nutracêuticos. Nesse contexto a curcumina, um pigmento amarelo-alaranjado extraído do rizoma da planta Curcuma longa L. se destaca como um promissor nutracêutico, apresentando um amplo potencial terapêutico e a cada dia encontra maior embasamento científico com a elucidação de seus mecanismos de ação sobre vários alvos moleculares importantes para a fisiopatologia de diversas doenças. A curcumina é bastante conhecida e explorada pela medicina asiática tradicional, principalmente pelas medicinas Ayurvédica e Chinesa. Utilizando o Pubmed e o Scielo como banco de dados para a pesquisa de trabalhos científicos, foi elaborada uma revisão bibliográfica com a compilação de estudos com diversos enfoques em relação à curcumina, a saber: i) características físico-químicas da curcumina; ii) propriedades anti-inflamatória, antioxidante, antidiabética, antitumoral, antiviral, antibacteriana, antiparasitária e antifúngica; iii) estratégias recentemente utilizadas para melhorar sua biodisponibilidade, tais como co-admnistração da piperina, síntese de análogos moleculares e sistemas inovadores de entrega como os sistemas coloidais (lipossomas e nanopartículas) e a complexação com ciclodextrina.

Produção de fitase por Rhizopus microsporus var. microsporus: purificação, caracterização bioquímica e aplicação

Pós-graduação em Biotecnologia - IQ

Inorganic and organic trace mineral supplementation in weanling pig diets

A study was conducted to evaluate the s of dietary inorganic and organic trace minerals in two levels of supplementation regarding performance, diarrhea occurrence, hematological parameters, fecal mineral excretion and mineral retention in metacarpals and liver of weanling pigs. Seventy piglets weaned at 21 days of age with an average initial body weight of 6.70 ± 0.38 kg were allotted in five treatments: control diet (no added trace mineral premix); 50% ITMP (control diet with inorganic trace mineral premix supplying only 50% of trace mineral requirements); 50% OTMP (control diet with organic trace mineral premix supplying only 50% of trace mineral requirements); 100% ITMP (control diet with inorganic trace mineral premix supplying 100% of trace mineral requirements); and 100% OTMP (control diet with organic trace mineral premix supplying 100% of trace mineral requirements). Feed intake and daily weight gain were not affected by treatments, however, piglets supplemented by trace minerals presented better gain:feed ratio. No differences were observed at calcium, phosphorus, potassium, magnesium, sodium and sulfur excreted in feces per kilogram of feed intake. Treatments did not affect calcium, phosphorus, magnesium, sulfur and iron content in metacarpals. Trace mineral supplementation, regardless of level and source, improved the performance of piglets.

Efeitos da flutamida na morfologia dos órgãos reprodutivos e fígado de Rhinella schneideri (Anura: Bufonidae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise in vitro da proliferação celular e produção de mediadores inflamatórios por células da conjuntiva estimuladas por materiais utilizados na confecção de próteses oculares

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Organic phosphorus fractions in soil fertilized with cattle manure

Inorganic phosphorus (Pi) usually controls the P availability in tropical soils, but the contribution of organic P (Po) should not be neglected, mainly in systems with low P input or management systems that promote organic matter accumulation. The aims of this study were to evaluate the changes in the Po fractions over time in soil fertilized and not fertilized with cattle manure and to correlate Po forms with available P extracted by anion exchange resin. The experiment was carried out under field conditions, in a sandy-clay loam Haplustox. The experimental design was a 2 x 9 randomized complete block factorial design, in which the first factor was manure application (20 t ha(-1)) or absence, and the second the soil sampling times (3, 7, 14, 21, 28, 49, 70, 91, and 112 days) after manure incorporation. Labile, moderately labile and non-labile Po fractions were determined in the soil material of each sampling. Manure fertilization increased the Po levels in the moderately labile and non-labile fractions and the total organic P, but did not affect the Po fraction proportions in relation to total organic P. On average, 5.1 % of total Po was in the labile, 44.4 % in the moderately labile and 50.5 % in the non-labile fractions. Available P (resin P) was more affected by the manure soluble Pi rather than by the labile Po forms. The labile and non-labile Po fractions varied randomly with no defined trend in relation to the samplings; for this reason, the data did not fit any mathematical model.

Sensoriamento remoto multifonte aplicado na detecção do fitoplâncton em águas interiores

Blooms of phytoplankton can be a risk to human health and aquatic biota, so the adoption of monitoring methods of phytoplankton and mechanisms for preventing its occurrence are needed. Thus, traditional monitoring methods could be more effective if complemented by approaches using the optical properties of phytoplankton pigments by means of Remote Sensing. In order to evaluate the potential of multi-scale remote sensing for detection of the phytoplankton activity, a study area was selected in Nova Avanhandava reservoir, located in the Tiete River, SP. For this analysis, hyperspectral field data and multispectral images of low and medium spatial resolution (Modis and RapidEye) were acquired and were related to indicator limnological variables of phytoplankton behavior; chlorophyll a and phycocyanin. The results show that a specific spectral band of RapidEye system (690-730 nm) allowed detect chlorophyll a and to evaluate the phytoplankton biomass, however hyperspectral data are needed to detect the phycocyanin pigment, indicative of cyanobacteria.

Mapeamento de cianobactérias por meio da fluorescência da ficocianina e de análise geoestatística

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Treatment efficiency of effluent prawn culture by wetland with floating aquatic macrophytes arranged in series

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Participação do óxido nítrico na fisiopatologia da doença renal crônica

Nitric oxide (NO) is a free radical gas, inorganic, which has seven electrons of nitrogen and oxygen eight, possessing an unpaired electron. This radical is produced from L-arginine by a reaction mediated by the enzyme NO synthase. NO it is about a radical of who acts abundant on a variety of biological processes, particularly when produced by endothelial cells plays a significant role in cardiovascular control, as a modulator of peripheral vascular resistance and platelet aggregation. This free radical has also a neurotransmitter and mediator of the immune system. NO kidney function has been considered in many physiological functions such as: (a) regulation of hemodynamics and glomerular function tubuloglomerular, (b) participation in pressure natriuresis (c) maintaining medullar perfusion (d) inhibiting sodium reabsorption tubular, and (e) acting as a modulator of the activity of the sympathetic nervous system. Given these functions, the occurrence of its deficiency is associated with chronic kidney disease (CKD) in vasoconstriction and consequently glomerular hypertension, high blood pressure (HBP), proteinuria and progression of renal dysfunction. This work has the scope to describe the role of NO in renal physiology and pathophysiology of CKD.

Effects of biodegradable detergents in the accumulation of lipofuscin (age pigment) in gill and liver of two neotropical fish species

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Preparação e caracterização de materiais híbridos celulose/NbOPO4.nH2O a partir de celulose branqueada de bagaço de cana-de-açúcar

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conteúdo de fósforo de alimentos consumidos por pacientes em hemodiálise crônica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Retenção de clorofila em sementes de soja (Glycine max (L.) Merr.): estudos fisiológicos, bioquímicos e moleculares

Pós-graduação em Agronomia (Agricultura) - FCA

Pododermatite e qualidade de carcaça de frangos de corte suplementados com minerais orgânicos e vitamina E

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)