Costa Rica: niveles y tendencias de la mortalidad infantil, según zona de residencia y nivel de instrucción de las mujeres, períodos 1962-1969; trabajo de investigacion

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Interrelación de la población con necesidad de producción y calidad de vivienda en Managua. Nicaragua

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Características de la jefatura de hogar femenina en Venezuela

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Problemas habitacionales en suburbios del área metropolitana de Asunción Paraguay

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Avaliação nutricional inicial e evolutiva de pacientes com injúria renal aguda

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Insuficiência renal aguda no Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP: descrição da população e análise dos fatores de risco associados a mortalidade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O papel do diretor na administração escolar: ontem e hoje

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Influência da nifedipina sobre a incidência de insuficiência renal aguda no pós-operatório de revascularização do miocárdio com circulação extracorpórea

Pós-graduação em Bases Gerais da Cirurgia - FMB

Fontes, doses e épocas de aplicação de nitrogênio em feijoeiro de inverno irrigado no sistema plantio direto

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação da mortalidade e recuperação renal de pacientes com insuficiência renal aguda submetidos à diálise com diferentes níveis de uréia

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Carlos Correa Mascaro e Moysés Brejon: contribuições dos assistentes de cátedra de José Quirino Ribeiro para a administração escolar no Brasil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Epigenetic alterations in human brain tumors in a Brazilian population

Aberrant methylation of CpG islands located in promoter regions represents one of the major mechanisms for silencing cancer-related genes in tumor cells. We determined the frequency of aberrant CpG island methylation for several tumor-associated genes: DAPK, MGMT, p14^ARF, p16^INK4a, TP73, RB1 and TIMP-3 in 55 brain tumors, consisting of 26 neuroepithelial tumors, 6 peripheral nerve tumors, 13 meningeal tumors and 10 metastatic brain tumors. Aberrant methylation of at least one of the seven genes studied was detected in 83.6% of the cases. The frequencies of aberrant methylation were: 40% for p14^ARF, 38.2% for MGMT, 30.9% for, p16^INK4a, 14.6% for TP73 and for TIMP-3, 12.7% for DAPK and 1.8% for RB1. These data suggest that the hypermethylation observed in the genes p14^ARF, MGMT and p16^INK4a is a very important event in the formation or progression of brain tumors, since the inactivation of these genes directly interferes with the cell cycle or DNA repair. The altered methylation rate of the other genes has already been reported to be related to tumorigenesis, but the low methylation rate of RB1 found in tumors in our sample is different from that so far reported in the literature, suggesting that perhaps hypermethylation of the promoter is not the main event in the inactivation of this gene. Our results suggest that hypermethylation of the promoter region is a very common event in nervous system tumors.

Sistemas de cultivo para o milho de primeira safra e doses de nitrogênio em feijoeiro e trigo em sucessão

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Entre abanicos e castanholas: recepção de Clarice Lispector na Espanha

Pós-graduação em Letras - IBILCE

Adubação nitrogenada em feijoeiro em sucessão a cultivo solteiro e consorciado de milho e Urochloa ruziziensis

The expansion of the no-tillage system, in Brazil, has increasingly diversified the ways in which the production methods are established and managed. This study aimed at evaluating the influence of preceding crops such as mayze and Urochloa ruziziensis, as well as their intercropping, in the presence and absence of seed inoculation with Azospirillum brasilense, and the cover nitrogen supplying on common bean development, production components and grain yield. The study was carried out in Selvíria, Mato Grosso do Sul State, Brazil, in the 2011/2012 crop season. The experimental design was randomized blocks, with four replications, in a 8x4 factorial scheme, with treatments consisting of a combination of cover crops (associations of mayze, U. ruziziensis and A. brasilense) and cover nitrogen doses on common bean (0 kg ha-1, 30 kg ha-1, 60 kg ha-1 and 90 kg ha-1). The preceding crops affected the common bean grain yield, with the mayze and Urochloa intercropping, both inoculated, being the best option. The initial common bean population was not affected by previous crops. The cover nitrogen application did not affect the common bean grain yield under winter irrigation, for the no-tillage system.