889 resultados para Ovid, 43 B.C.-17 A.D. or 18 A.D


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Welsch (Projektbearbeiter): Aufruf zur Beibehaltung des Prinzips der indirekten Urwahlen (1 Wahlmann auf 500 Wähler). Zurückweisung der Argumentation, es bestünde die Gefahr, daß die solchermaßen gewählten Wahlmänner von der Regierung (Ministerium Camphausen) bestochen würden

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Human c-sis/PDGF-B proto-oncogene has been shown to be overexpressed in a large percentage of human tumor cells establishing a growth-promoting, autocrine growth circuit. Triplex forming oligonucleotides (TFOs) can recognize and bind sequences in duplex DNA, and have received considerable attention because of their potential for targeting specific genomic sites. The c-sis/PDGF-B promoter contains a unique homopurine/homopyrimidine sequence (SIS proximal element, SPE), which is crucial for binding nuclear factors that provoke transcription. In order to develop specific transcriptional inhibitors of the human c-sis/PDGF-B proto-oncogene, 20 potential TFOs targeting part or all of the SPE were screened by gel mobility analysis. DNase I footprinting shows that the TFOs we designed can form a sequence-specific triplex with the target. Protein binding assays demonstrate that triplex formation inhibits nuclear factors binding the c-sis/PDGF-B promoter. Both transient and stable transfection experiments demonstrate that the transcriptional activity of the promoter is considerably inhibited by the TFOs. We propose that TFOs represent a therapeutic potential to specifically diminish the expression of c-sis/PDGF-B proto-oncogene in various pathologic settings where constitutive expression of this gene has been observed.

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Written in one column, 17 lines per page, in black ink. Text includes tables. Comments in the margins.

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بسم الله الرحمن الرحيم الحمد لله الذي بعث محمد صلى الله عليه وسلم رحمة للعالمين ... :Incipit

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Comprises title leaf, and 29 views etched by J. Harris. Last plate has additional legend: H. Beighton delin. 1715.

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Vita.

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Risālat al-iʻtiqādāt, by Muḥammad Bāqir Majlisī: p. 480-519.