Fort Stanwix, Fort Stanwix National Monument, New York /

Aerial view (partly photographic) of reconstructed Revolutionary War fort.

Women's Rights National Historical Park, Seneca Falls, New York /

Panel title.

Marine casualty report : entanglement of the submersible Johnson Sea Link with submerged wreckage off Key West, Florida on or about 17 June 1973 with loss of life : U.S. Coast Guard Marine Board of Investigation report and commandant's action : action by National Transportation Safety Board /

Cover title.

Marine casualty report : SS C. V. Sea Witch - SS Esso Brussels (Belgium) : collision and fire in New York Harbor on June 1973 with loss of life : U.S. Coast Guard Marine Board of Investigation report and commandant's action : action by National Transportation Safety Board.

"Report no. USCG/NTSB-MAR-75-6."

Delaware Water Gap National Recreation Area. Aug. 1968.

Scale ca. 1:220,000.

Rehabilitation of Childs Park, Delaware Water Gap National Recreation Area (NRA) : environmental assessment, public scoping meetings, July 11 & 12, 2006 /

Shows recommended changes at the Childs Park recreation area within the N.R.A. on the Pa. side of the Delaware River.

Delaware Water Gap National Recreation Area, Pennsylvania and New Jersey, river guide /

Shows boating, camping, and canoe rental facilities.

Edwin B. Forsythe National Wildlife Refuge /

Includes location map (inset).

Gateway National Recreation Area, New York-New Jersey /

Scale ca. 1:68,000.

Gateway National Recreation Area, New York-New Jersey /

Scale ca. 1:68,000.

Edison National Historic Site, West Orange, New Jersey. May 1957.

Scale ca. 1:1,100.

Thomas Edison : Thomas Edison National Historical Park, New Jersey /

"*GPO:2008--339-126/80165."

Adaptive Immunity against Leishmania Nucleoside Hydrolase Maps Its C-Terminal Domain as the Target of the CD4+ T Cell-Driven Protective Response

Nucleoside hydrolases (NHs) show homology among parasite protozoa, fungi and bacteria. They are vital protagonists in the establishment of early infection and, therefore, are excellent candidates for the pathogen recognition by adaptive immune responses. Immune protection against NHs would prevent disease at the early infection of several pathogens. We have identified the domain of the NH of L. donovani (NH36) responsible for its immunogenicity and protective efficacy against murine visceral leishmaniasis (VL). Using recombinant generated peptides covering the whole NH36 sequence and saponin we demonstrate that protection against L. chagasi is related to its C-terminal domain (amino-acids 199-314) and is mediated mainly by a CD4+ T cell driven response with a lower contribution of CD8+ T cells. Immunization with this peptide exceeds in 36.73 +/- 12.33% the protective response induced by the cognate NH36 protein. Increases in IgM, IgG2a, IgG1 and IgG2b antibodies, CD4+ T cell proportions, IFN-gamma secretion, ratios of IFN-gamma/IL-10 producing CD4+ and CD8+ T cells and percents of antibody binding inhibition by synthetic predicted epitopes were detected in F3 vaccinated mice. The increases in DTH and in ratios of TNF alpha/IL-10 CD4+ producing cells were however the strong correlates of protection which was confirmed by in vivo depletion with monoclonal antibodies, algorithm predicted CD4 and CD8 epitopes and a pronounced decrease in parasite load (90.5-88.23%; p = 0.011) that was long-lasting. No decrease in parasite load was detected after vaccination with the N-domain of NH36, in spite of the induction of IFN-gamma/IL-10 expression by CD4+ T cells after challenge. Both peptides reduced the size of footpad lesions, but only the C-domain reduced the parasite load of mice challenged with L. amazonensis. The identification of the target of the immune response to NH36 represents a basis for the rationale development of a bivalent vaccine against leishmaniasis and for multivalent vaccines against NHs-dependent pathogens.

THE SPECTRAL EVOLUTION AND EJECTA OF RECURRENT NOVA U Sco IN THE 2010 OUTBURST

Synoptic spectroscopic observations of the U Sco 2010 outburst from maximum light to quiescence as well as a contemporaneous X-ray observation are presented and analyzed. The X-ray spectrum 52 days after outburst indicates a hot source ( kT(bb) similar to 70 eV). Narrow-line components from the irradiated companion atmosphere were observed in hydrogen and helium optical recombination lines. The formation of a nebular spectrum is seen for the first time in this class of recurrent novae, allowing a detailed study of the ejecta using photoionization models. Unusual [O III] auroral-to-nebular line ratios were found and possible scenarios of their origin are discussed. The modeling of the emission line spectrum suggests highly heterogeneous ejecta with masses around or above 3 x 10(-6) M(sun).

Transport properties in nontwist area-preserving maps

Nontwist systems, common in the dynamical descriptions of fluids and plasmas, possess a shearless curve with a concomitant transport barrier that eliminates or reduces chaotic transport, even after its breakdown. In order to investigate the transport properties of nontwist systems, we analyze the barrier escape time and barrier transmissivity for the standard nontwist map, a paradigm of such systems. We interpret the sensitive dependence of these quantities upon map parameters by investigating chaotic orbit stickiness and the associated role played by the dominant crossing of stable and unstable manifolds. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3247349]