ERVING GOFFMAN, AS INTERAÇÕES NO COTIDIANO ESCOLAR, DESVENDANDO O ESTIGMA DENTRO DA INCLUSÃO ESCOLAR

As pessoas com deficiências são excluídas da sociedade devido à marca negativa de descrédito recebida pelo meio social - por sua aparência ou seu modo de ser diferentes - que os coloca fora da norma classificando-os como seres desviantes. No cotidiano escolar essas marcas se afirmam e se reproduzem, não promovendo às pessoas com deficiências uma superação desse estigma. A pesquisa visa analisar como o estigma incorporado pelos alunos com deficiências influencia no processo de interação e inclusão escolar, de forma a estudar indícios de como se desenvolve o processo de estigmatização no cotidiano escolar sob a luz dos pensamentos de Erving Goffman. O presente estudo utiliza-se uma revisão de literatura especifica do tema, fundamentada nos estudos de Erving Goffman, conjuntamente à pesquisa empírica baseada na etnografia vivenciada pelo autor em seus estudos de comunidade, foram utilizadas como estratégias de pesquisa, entrevistas com três professores e observações registradas por meio de de observação de cenas do cotidiano escolar de ´duas escolas públicas do estado de SPSão Paulo . No capítulo 1 buscamos entender os constructos de Goffman principalmente por meio de sua trajetória acadêmica, no capítulo 2 o trabalho centrou-se na compreensão da interação social e principalmente na questão definida pelo autor como ordem da interação, em queentende-se que as pessoas são autores dentro de um palco social, no capítulo 3. a pesquisa aborda o termo estigma e explica sua influência na interação e no avanço das pessoas com deficiência. Por fim, o trabalho se encerra no capítulo .4 apresentando a análise das entrevistas e dos registros das cenas do cotidiano escolar. As cenas selecionadas apresentam os atores envolvidos, o cenário, e o enredo das interações, identificando as estratégias do estigma incorporado pelos alunos com deficiência e buscando ligações com as políticas inclusivas e as escolas brasileira. A pesquisa identificou que a escola, como meio de socialização e criação de saberes, possui um papel importante neste processo de mudança, apesar de muitas vezes reproduzir o estigma social. Observamos então que a escola pode auxiliar na mudança do olhar que exclui, à maneira que mostra algumas máscaras do social e da própria inclusão; no entanto é importante salientar que sua renovação e de seus agentes sociais deve valorizar as diferenças para construção de novos conhecimentos.(AU)

ERVING GOFFMAN, AS INTERAÇÕES NO COTIDIANO ESCOLAR, DESVENDANDO O ESTIGMA DENTRO DA INCLUSÃO ESCOLAR

As pessoas com deficiências são excluídas da sociedade devido à marca negativa de descrédito recebida pelo meio social - por sua aparência ou seu modo de ser diferentes - que os coloca fora da norma classificando-os como seres desviantes. No cotidiano escolar essas marcas se afirmam e se reproduzem, não promovendo às pessoas com deficiências uma superação desse estigma. A pesquisa visa analisar como o estigma incorporado pelos alunos com deficiências influencia no processo de interação e inclusão escolar, de forma a estudar indícios de como se desenvolve o processo de estigmatização no cotidiano escolar sob a luz dos pensamentos de Erving Goffman. O presente estudo utiliza-se uma revisão de literatura especifica do tema, fundamentada nos estudos de Erving Goffman, conjuntamente à pesquisa empírica baseada na etnografia vivenciada pelo autor em seus estudos de comunidade, foram utilizadas como estratégias de pesquisa, entrevistas com três professores e observações registradas por meio de de observação de cenas do cotidiano escolar de ´duas escolas públicas do estado de SPSão Paulo . No capítulo 1 buscamos entender os constructos de Goffman principalmente por meio de sua trajetória acadêmica, no capítulo 2 o trabalho centrou-se na compreensão da interação social e principalmente na questão definida pelo autor como ordem da interação, em queentende-se que as pessoas são autores dentro de um palco social, no capítulo 3. a pesquisa aborda o termo estigma e explica sua influência na interação e no avanço das pessoas com deficiência. Por fim, o trabalho se encerra no capítulo .4 apresentando a análise das entrevistas e dos registros das cenas do cotidiano escolar. As cenas selecionadas apresentam os atores envolvidos, o cenário, e o enredo das interações, identificando as estratégias do estigma incorporado pelos alunos com deficiência e buscando ligações com as políticas inclusivas e as escolas brasileira. A pesquisa identificou que a escola, como meio de socialização e criação de saberes, possui um papel importante neste processo de mudança, apesar de muitas vezes reproduzir o estigma social. Observamos então que a escola pode auxiliar na mudança do olhar que exclui, à maneira que mostra algumas máscaras do social e da própria inclusão; no entanto é importante salientar que sua renovação e de seus agentes sociais deve valorizar as diferenças para construção de novos conhecimentos.(AU)

The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization

Positioning of the Z ring at the midcell site in Escherichia coli is assured by the min system, which masks polar sites through topological regulation of MinC, an inhibitor of division. To study how MinC inhibits division, we have generated a MalE-MinC fusion that retains full biological activity. We find that MalE-MinC interacts with FtsZ and prevents polymerization without inhibiting FtsZ's GTPase activity. MalE-MinC19 has reduced ability to inhibit division, reduced affinity for FtsZ, and reduced ability to inhibit FtsZ polymerization. These results, along with MinC localization, suggest that MinC rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.

Optical images of visible and invisible percepts in the primary visual cortex of primates

We optically imaged a visual masking illusion in primary visual cortex (area V-1) of rhesus monkeys to ask whether activity in the early visual system more closely reflects the physical stimulus or the generated percept. Visual illusions can be a powerful way to address this question because they have the benefit of dissociating the stimulus from perception. We used an illusion in which a flickering target (a bar oriented in visual space) is rendered invisible by two counter-phase flickering bars, called masks, which flank and abut the target. The target and masks, when shown separately, each generated correlated activity on the surface of the cortex. During the illusory condition, however, optical signals generated in the cortex by the target disappeared although the image of the masks persisted. The optical image thus was correlated with perception but not with the physical stimulus.

MethDB—a public database for DNA methylation data

Methylation of cytosine in the 5 position of the pyrimidine ring is a major modification of the DNA in most organisms. In eukaryotes, the distribution and number of 5-methylcytosines (5mC) along the DNA is heritable but can also change with the developmental state of the cell and as a response to modifications of the environment. While DNA methylation probably has a number of functions, scientific interest has recently focused on the gene silencing effect methylation can have in eukaryotic cells. In particular, the discovery of changes in the methylation level during cancer development has increased the interest in this field. In the past, a vast amount of data has been generated with different levels of resolution ranging from 5mC content of total DNA to the methylation status of single nucleotides. We present here a database for DNA methylation data that attempts to unify these results in a common resource. The database is accessible via WWW (http://www.methdb.de). It stores information about the origin of the investigated sample and the experimental procedure, and contains the DNA methylation data. Query masks allow for searching for 5mC content, species, tissue, gene, sex, phenotype, sequence ID and DNA type. The output lists all available information including the relative gene expression level. DNA methylation patterns and methylation profiles are shown both as a graphical representation and as G/A/T/C/5mC-sequences or tables with sequence positions and methylation levels, respectively.

Nonsense-mediated Decay of mRNA for the Selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase Is Detectable in Cultured Cells but Masked or Inhibited in Rat Tissues

Previous studies of mRNA for classical glutathione peroxidase 1 (GPx1) demonstrated that hepatocytes of rats fed a selenium-deficient diet have less cytoplasmic GPx1 mRNA than hepatocytes of rats fed a selenium-adequate diet. This is because GPx1 mRNA is degraded by the surveillance pathway called nonsense-mediated mRNA decay (NMD) when the selenocysteine codon is recognized as nonsense. Here, we examine the mechanism by which the abundance of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA, another selenocysteine-encoding mRNA, fails to decrease in the hepatocytes and testicular cells of rats fed a selenium-deficient diet. We demonstrate with cultured NIH3T3 fibroblasts or H35 hepatocytes transiently transfected with PHGPx gene variants under selenium-supplemented or selenium-deficient conditions that PHGPx mRNA is, in fact, a substrate for NMD when the selenocysteine codon is recognized as nonsense. We also demonstrate that the endogenous PHGPx mRNA of untransfected H35 cells is subject to NMD. The failure of previous reports to detect the NMD of PHGPx mRNA in cultured cells is likely attributable to the expression of PHGPx cDNA rather than the PHGPx gene. We conclude that 1) the sequence of the PHGPx gene is adequate to support the NMD of product mRNA, and 2) there is a mechanism in liver and testis but not cultured fibroblasts and hepatocytes that precludes or masks the NMD of PHGPx mRNA.

Rethinking cell structure.

Cell structure, emerging from behind the veil of conventional electron microscopy, appears far more complex than formerly realized. The standard plastic-embedded, ultrathin section can image only what is on the section surface and masks the elaborate networks of the cytoplasm and nucleus. Embedment-free electron microscopy gives clear, high-contrast micrographs of cell structure when combined with removal of obscuring material such as soluble proteins. The resinless ultrathin section is the technique of choice; it is simple and inexpensive, and it uses ordinary electron microscopes. The resulting pictures reveal a world of complex cell structure and function. These images necessarily change our conception of the cytoskeleton, nuclear matrix, mitosis, and the relation of membranes to cytostructure.

Neural-network-based classification of cognitively normal, demented, Alzheimer disease and vascular dementia from single photon emission with computed tomography image data from brain.

Single photon emission with computed tomography (SPECT) hexamethylphenylethyleneamineoxime technetium-99 images were analyzed by an optimal interpolative neural network (OINN) algorithm to determine whether the network could discriminate among clinically diagnosed groups of elderly normal, Alzheimer disease (AD), and vascular dementia (VD) subjects. After initial image preprocessing and registration, image features were obtained that were representative of the mean regional tissue uptake. These features were extracted from a given image by averaging the intensities over various regions defined by suitable masks. After training, the network classified independent trials of patients whose clinical diagnoses conformed to published criteria for probable AD or probable/possible VD. For the SPECT data used in the current tests, the OINN agreement was 80 and 86% for probable AD and probable/possible VD, respectively. These results suggest that artificial neural network methods offer potential in diagnoses from brain images and possibly in other areas of scientific research where complex patterns of data may have scientifically meaningful groupings that are not easily identifiable by the researcher.

Resonant elements contactless coupled to bolometric micro-stripes

One of the main technical difficulties in the fabrication of optical antennas working as light detectors is the proper design and manufacture of auxiliary elements as load lines and signal extraction structures. These elements need to be quite small to reach the location of the antennas and should have a minimal effect on the response of the device. Unfortunately this is not an easy task and signal extraction lines resonate along with the antenna producing a complex signal that usually masks the one given by the antenna. In order to decouple the resonance from the transduction we present in this contribution a parametric analysis of the response of a bolometric stripe that is surrounded by resonant dipoles with different geometries and orientations. We have checked that these elements should provide a signal proportional to the polarization state of the incoming light.

Testing diagnostics of nuclear activity and star formation in galaxies at z > 1

We present some of the first science data with the new Keck/MOSFIRE instrument to test the effectiveness of different AGN/SF diagnostics at z ~ 1.5. MOSFIRE spectra were obtained in three H-band multi-slit masks in the GOODS-S field, resulting in 2 hr exposures of 36 emission-line galaxies. We compare X-ray data with the traditional emission-line ratio diagnostics and the alternative mass-excitation and color-excitation diagrams, combining new MOSFIRE infrared data with previous HST/WFC3 infrared spectra (from the 3D-HST survey) and multiwavelength photometry. We demonstrate that a high [O III]/Hβ ratio is insufficient as an active galactic nucleus (AGN) indicator at z > 1. For the four X-ray-detected galaxies, the classic diagnostics ([O III]/Hβ versus [N II]/Hα and [S II]/Hα) remain consistent with X-ray AGN/SF classification. The X-ray data also suggest that "composite" galaxies (with intermediate AGN/SF classification) host bona fide AGNs. Nearly ~2/3 of the z ~ 1.5 emission-line galaxies have nuclear activity detected by either X-rays or the classic diagnostics. Compared to the X-ray and line ratio classifications, the mass-excitation method remains effective at z > 1, but we show that the color-excitation method requires a new calibration to successfully identify AGNs at these redshifts.

Determinação do contorno pulmonar orientado em sequências temporais de imagens de RM pela transformada de Hough.

O estudo do movimento pulmonar é assunto de grande interesse na área médica. A observação direta do mesmo é inviável, uma vez que o pulmão colapsa quando a caixa torácica é aberta. Dentre os meios de observação indireta, escolheu-se o imageamento por ressonância magnética em respiração livre e sem uso de nenhum gás para melhorar o contraste ou qualquer informação de sincronismo. Esta escolha propõe diversos desafios, como: a superar a alta variação na qualidade das imagens, que é baixa, em geral, e a suscetibilidade a artefatos, entre outras limitações a serem superadas. Imagens de Tomografia Computadorizada apresentam melhor qualidade e menor tempo de aquisição, mas expõem o paciente a níveis consideráveis de radiação ionizante. É apresentada uma metodologia para segmentação do pulmão, produzindo um conjunto de pontos coordenados. Isto é feito através do processamento temporal da sequência de imagens de RM. Este processamento consiste nas seguintes etapas: geração de imagens temporais (2DSTI), transformada de Hough modificada, algoritmo de contornos ativos e geração de silhueta. A partir de um dado ponto, denominado centro de rotação, são geradas diversas imagens temporais com orientações variadas. É proposta uma formulação modificada da transformada de Hough para determinar curvas parametrizadas que sejam síncronas ao movimento diafragmático, chamados movimentos respiratórios. Também são utilizadas máscaras para delimitar o domínio de aplicação da transformada de Hough. São obtidos movimentos respiratórios que são suavizados pelo algoritmo de contornos ativos e, assim, permitem a geração de contornos para cada quadro pertencente a sequência e, portanto, de uma silhueta do pulmão para cada sequência.

Reviewing the EU’s Crisis Management Procedures. IES Policy Brief Issue 2012/04/November 2012

Summary. The ongoing review of the EU’s Crisis Management Procedures warrants attention. What passes as an update of an arcane and technical document masks a profoundly political debate concerning what the Common Security and Defence Policy (CSDP) should be about. This policy brief summarises the main proposals and formulates a set of critical reflections. It calls for replacing the bureaucratic scheming with a more forthright political debate, and warns against sacrificing incompatible organisational cultures on the altar of the comprehensive approach. At a time when European security and prosperity trends are increasingly pointing downwards, the EEAS and the member states must look to the future and embrace, rather than resist, change.

What do Eurozone academics think about EMU reform? On broad support and German exceptionalism. Bruges Political Research Papers 41/2015.

This paper is an empirical contribution to the literature on the formation of policy preferences on Economic and Monetary Union (EMU) reform within its Member States. In the aftermath of the euro crisis, many proposals to ‘complete’ EMU have been tabled. However, discord among Member States has led to a piecemeal restructuring of EMU. For this paper, a survey has been conducted among euro area academic experts, gauging preferences on EMU reform. We find that general consensus masks significant discord among academics from different Member States. Our data indicates the existence of conflicting national epistemic communities, bound by shared causal beliefs on macro-economic policy. Academics within the key creditor Member State, Germany, assume an outlier position. Within the sample of German academics, economists are particularly strongly opposed to all moves in the direction of fiscal or social union. As economists are those academic experts most likely to influence the economic policy beliefs dominant among the German policy elite, these results are highly politically salient. We confront these findings with the literature on the exceptionalism of German economics. We contend that our results substantiate the claim that inadequate EMU reform and, more generally, the EU approach to the Eurozone crisis, can be partially explained by the firm grip these economic doctrines hold over the economics profession and policy-making circles in Germany.

Columbina e Pierrot ‒ A Evidência de Traços do Expressionismo em Três Máscaras de José Régio

Três Máscaras, um texto dramático da autoria de José Régio, insere-se na tradição realista do teatro social de atualidade da época, todavia denuncia já alguns traços do expressionismo. Com efeito, nesta fantasia dramática, duas personagens, Columbina e Pierrot, assinalam, numa fase embrionária, alguns lineamentos indicativos da principal temática do teatro expressionista, na medida em que ― sonhadores, tristes, sofredores e humilhados nas e pelas respetivas posições socioeconómicas específicas ― manifestam interesse no alcance da individualidade e do carácter do homem livre orgulhosamente associal. Acusam, assim, um certo antagonismo perante a generalidade social padronizadora, visando assinalar uma ética individual.

Global 2009 1km MODIS (MOD35/MOD09) cloud frequency and MOD35 processing path

Identifying cloud interference in satellite-derived data is a critical step toward developing useful remotely sensed products. Most MODIS land products use a combination of the MODIS (MOD35) cloud mask and the 'internal' cloud mask of the surface reflectance product (MOD09) to mask clouds, but there has been little discussion of how these masks differ globally. We calculated global mean cloud frequency for both products, for 2009, and found that inflated proportions of observations were flagged as cloudy in the Collection 5 MOD35 product. These erroneously categorized areas were spatially and environmentally non-random and usually occurred over high-albedo land-cover types (such as grassland and savanna) in several regions around the world. Additionally, we found that spatial variability in the processing path applied in the Collection 5 MOD35 algorithm affects the likelihood of a cloudy observation by up to 20% in some areas. These factors result in abrupt transitions in recorded cloud frequency across landcover and processing-path boundaries impeding their use for fine-scale spatially contiguous modeling applications. We show that together, these artifacts have resulted in significantly decreased and spatially biased data availability for Collection 5 MOD35-derived composite MODIS land products such as land surface temperature (MOD11) and net primary productivity (MOD17). Finally, we compare our results to mean cloud frequency in the new Collection 6 MOD35 product, and find that landcover artifacts have been reduced but not eliminated. Collection 6 thus increases data availability for some regions and land cover types in MOD35-derived products but practitioners need to consider how the remaining artifacts might affect their analysis.