Haydn's celebrated overture composed for & performed at Mr. Salomon's concert Hanover-Square : adapted for the piano-forte, with an accompaniment for a violin & violoncello ad libitum. N. 2, Sinfonia II [Música notada]

Hay un ejemplar encuadernado con: Deux sonates et La Coquette pour forte piano (XVIII/2815). Firma autógrafa de J.C. Salomon en la port.

Overexpression of a Kinase-deficient Transforming Growth Factor-β Type II Receptor in Mouse Mammary Stroma Results in Increased Epithelial Branching

Members of the transforming growth factor-β (TGF-β) superfamily signal through heteromeric type I and type II serine/threonine kinase receptors. Transgenic mice that overexpress a dominant-negative mutation of the TGF-β type II receptor (DNIIR) under the control of a metallothionein-derived promoter (MT-DNIIR) were used to determine the role of endogenous TGF-βs in the developing mammary gland. The expression of the dominant-negative receptor was induced with zinc and was primarily localized to the stroma underlying the ductal epithelium in the mammary glands of virgin transgenic mice from two separate mouse lines. In MT-DNIIR virgin females treated with zinc, there was an increase in lateral branching of the ductal epithelium. We tested the hypothesis that expression of the dominant-negative receptor may alter expression of genes that are expressed in the stroma and regulated by TGF-βs, potentially resulting in the increased lateral branching seen in the MT-DNIIR mammary glands. The expression of hepatocyte growth factor mRNA was increased in mammary glands from transgenic animals relative to the wild-type controls, suggesting that this factor may play a role in TGF-β-mediated regulation of lateral branching. Loss of responsiveness to TGF-βs in the mammary stroma resulted in increased branching in mammary epithelium, suggesting that TGF-βs play an important role in the stromal–epithelial interactions required for branching morphogenesis.

Biochemical evolution II: Origin of life in tubular microstructures on weathered feldspar surfaces

Mineral surfaces were important during the emergence of life on Earth because the assembly of the necessary complex biomolecules by random collisions in dilute aqueous solutions is implausible. Most silicate mineral surfaces are hydrophilic and organophobic and unsuitable for catalytic reactions, but some silica-rich surfaces of partly dealuminated feldspars and zeolites are organophilic and potentially catalytic. Weathered alkali feldspar crystals from granitic rocks at Shap, north west England, contain abundant tubular etch pits, typically 0.4–0.6 μm wide, forming an orthogonal honeycomb network in a surface zone 50 μm thick, with 2–3 × 106 intersections per mm2 of crystal surface. Surviving metamorphic rocks demonstrate that granites and acidic surface water were present on the Earth’s surface by ∼3.8 Ga. By analogy with Shap granite, honeycombed feldspar has considerable potential as a natural catalytic surface for the start of biochemical evolution. Biomolecules should have become available by catalysis of amino acids, etc. The honeycomb would have provided access to various mineral inclusions in the feldspar, particularly apatite and oxides, which contain phosphorus and transition metals necessary for energetic life. The organized environment would have protected complex molecules from dispersion into dilute solutions, from hydrolysis, and from UV radiation. Sub-micrometer tubes in the honeycomb might have acted as rudimentary cell walls for proto-organisms, which ultimately evolved a lipid lid giving further shelter from the hostile outside environment. A lid would finally have become a complete cell wall permitting detachment and flotation in primordial “soup.” Etch features on weathered alkali feldspar from Shap match the shape of overlying soil bacteria.

Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis

Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production. In animal models of arthritis, treatment with recombinant human IL-11 (rhIL-11) reduces both the level of synovitis and the histologic lesion scores in the joints.

La emigración cualificada española en Francia y Alemania

A pesar del interés que despierta el fenómeno de las migraciones cualificadas, es difícil encontrar datos que permitan realizar un análisis detallado de los factores que condicionan la movilidad. El caso español constituye un ejemplo de la modificación cualitativa en la composición de las migraciones de sur a norte en Europa tras el ingreso en la Comunidad Económica Europea. No se produjeron migraciones masivas de trabajadores sin cualificación; sin embargo, sí se alteró drásticamente su composición: la migración no cualificada fue sustituida por migración cualificada de España a Alemania y Francia. Esta migración queda ocultada por la llegada masiva de inmigrantes a España. Empleando los datos de la encuesta EIMSS, se analizan las diferencias de las condiciones de egreso y movilidad entre los dos tipos de migrantes, cualificados y no cualificados.

Antonio Maura y el papel del II Reich en las negociaciones hispano-francesas sobre Marruecos de 1903-1904

En la primera parte del artículo se aborda el problema que ha de afrontar el estadista Antonio Maura al convertirse en el jefe del gobierno español, a finales de 1903 y consistente en concluir el proceso de negociación sobre Marruecos entablado con Francia desde 1901. Se resalta el carácter continuista del ideario colonial de Maura con respecto al del anterior líder conservador, Silvela, y la preponderancia de cuestiones como la seguridad nacional como motivadoras de dicho ideario. En la segunda parte, se explica la apelación del gobierno maurista a una ayuda por parte de Alemania, en función de movimientos previos de la diplomacia germana que se había interesado por controlar una parte del Marruecos español, o por conseguir compensaciones en Fernando Po. Finalmente se analiza el intento de Berlín de instrumentalizar al gobierno Maura en el curso de las conversaciones hispano-francesas sobre el Imperio jerifiano.

The Laws of Harvard College, 1790

Bound pamphlet copy of the 1790 College laws printed by Samuel Hall, with annotations attributed to Christophe Ebeling. Handwritten inscription on cover: "For Professor Ebeling of Hamburgh from Joseph Willard President of Harvard College in Cambridge." A list of the "present executive officers of the College" for June 1794 is handwritten on the back inside cover, and the number of students in College are listed on the verso.

[Admittatur of Samuel Abbot Kneeland (Harvard AB 1797)], 1793 August 15

Published copy of the 1790 College Laws, with the admittatur of undergraduate Samuel Abbot Kneeland signed by President Joseph Willard on August 15, 1793.

[Admittatur of Henry Gardner (Harvard AB 1798)], 1794 August 13

Published copy of the 1790 College Laws, in a modern hardcover binding, with the admittatur of undergraduate Henry Gardner signed by President Joseph Willard on August 13, 1794.

[Admittatur of Samuel Weed (Harvard AB 1800)], 1796 August 17

Published copy of the 1790 College Laws, bound in modern board binding, with the admittatur of undergraduate Samuel Weed signed by President Joseph Willard on August 17, 1796.

[Admittatur of Timothy Fuller (Harvard AB 1801)], 1797 August 18

Published copy of the 1790 College Laws with the admittatur of undergraduate Timothy Fuller signed by President Joseph Willard on August 18, 1797.

[Admittatur of Benjamin Merrill (Harvard AB 1804)], 1800 August 12

Published copy of the 1790 College Laws with the admittatur of undergraduate Benjamin Merrill signed by President Joseph Willard on August 12, 1800. Four pages of amendments of and additions to the Harvard Laws "enacted since the Summer of 1798, and are now in force Dec. 1, 1800" are tipped in at the beginning of the volume.

[Admittatur of Joseph Estabrook], 1818 February 16

Published copy of the 1816 College Laws with the admittatur of undergraduate Joseph Estabrook signed by President John Kirkland on February 16 , 1818.

Manuscript copy of Joseph Mayhew's complaints against Nathan Prince, Oct. 31, 1740 and Nov. 4, 1740

This is a manuscript copy of meeting minutes concerning fellow Tutor Joseph Mayhew's complaints against Nathan Prince. The minutes are written in a small paper-bound volume whose cover bears these inscriptions: "Oct. 31, 1740. Mr. Mayhew's complaint vs. Mr. Prince to the President and Tutors, Recd 14 Sept. 1741 of a Freshman, seal'd up;" "Acco of Mr. Mayhew's complaint of Mr. Prince contained in the Pres't & Tut's Book;" and "To the Honble Mr. Foxcroft, Chairman of the Committee of the Honble & Revd. the Overseers of Harvard College in Cambridge." Among other complaints, Mayhew was upset that Prince had called him "a Rascall & a rascally Fellow." The minutes also indicate that Prince left two meetings of the President and Tutors without permission, in spite of President Holyoke's having entreated him "Won't you stay?"