Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat

In this study we investigate the mRNA expression of inhibitory factor κBα (IκBα) in cells of the rat brain induced by an intraperitoneal (i.p.) injection of lipopolysaccharide (LPS). IκB controls the activity of nuclear factor κB, which regulates the transcription of many immune signal molecules. The detection of IκB induction, therefore, would reveal the extent and the cellular location of brain-derived immune molecules in response to peripheral immune challenges. Low levels of IκBα mRNA were found in the large blood vessels and in circumventricular organs (CVOs) of saline-injected control animals. After an i.p. LPS injection (2.5 mg/kg), dramatic induction of IκBα mRNA occurred in four spatio-temporal patterns. Induced signals were first detected at 0.5 hr in the lumen of large blood vessels and in blood vessels of the choroid plexus and CVOs. Second, at 1–2 hr, labeling dramatically increased in the CVOs and choroid plexus and spread to small vascular and glial cells throughout the entire brain; these responses peaked at 2 hr and declined thereafter. Third, cells of the meninges became activated at 2 hr and persisted until 12 hr after the LPS injection. Finally, only at 12 hr, induced signals were present in ventricular ependyma. Thus, IκBα mRNA is induced in brain after peripheral LPS injection, beginning in cells lining the blood side of the blood–brain barrier and progressing to cells inside brain. The spatiotemporal patterns suggest that cells of the blood–brain barrier synthesize immune signal molecules to activate cells inside the central nervous system in response to peripheral LPS. The cerebrospinal fluid appears to be a conduit for these signal molecules.

The effects of quality and environmental management on competitive advantage: A mixed methods study in the hotel industry

This paper reports results derived from a mixed methods study where 13 hotel managers were initially interviewed, followed by a quantitative study of 355 additional managers. Data were analysed using partial least squares path modelling. The research question related to the relationship between quality and environmental management and the competitive advantage sought by hotels. The results indicate that quality management and environmental management permit the improvement of competitive advantage in terms of both costs and differentiation. Moreover, hotels implementing quality programmes find fewer obstacles in implementing environmental management.

Changing kinship systems: a study in the acculturation of the Creeks, Cherokee, and Choctaw / by Alexander Spoehr, Curator, Oceanic Ethnology. Formerly Curator, North American Ethnology and Archaeology.

v.33:no.4(1947)

The Relevance of International Spillovers and Asymmetric Effects in the Taylor Rule. CEPS Working Document No. 403, February 2015

Deviations of policy interest rates from the levels implied by the Taylor rule have been persistent before the financial crisis and increased especially after the turn of the century. Compared to the Taylor benchmark, policy rates were often too low. This paper provides evidence that both international spillovers, for instance international dependencies in the interest rate-setting of central banks, and nonlinear reaction patterns can offer a more realistic specification of the Taylor rule in the main industrial countries. The inclusion of international spillovers and, even more, nonlinear dynamics improves the explanatory power of standard Taylor reaction functions. Deviations from Taylor rates tend to be smaller and their negative trend can be eliminated.

The reproductive development of the female, with especial reference to the period of adolescent sterility; a study in the comparative physiology of the infecundity of the adolescent organism.

First ed. published in 1946 under title: Adolescent sterility.

The German church on the American frontier; a study in the rise of religion among the Germans of the West,

Bibliography: p. [517]-531.

Lincoln, Nebraska ASAP telephone survey: a study in the effectiveness of a public information liquor campaign on alcohol and highway safety. Final report.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.

Protestantism; a study in the direction of religious truth and Christian unity.

"Explanatory index of authors cited," p. [433]-436.

Hard sayings of Jesus Christ : a study in the mind and method of the Master /

Mode of access: Internet.

A study in the design of an arithmetic element for serial processing in a linear iterative structure /

Vita.

The exclusive agency; a study in the marketing of manufactured products,

Mode of access: Internet.

Proceedings at the unveiling of the statute of John Sandfield Macdonald, first prime minister of Ontario in the Queen's park, Toronto, November 16th, 1909.

Mode of access: Internet.

The Reigate sheet of the one-inch Ordnance survey; a study in the geography of the Surrey hills,

Maps in detached pocket.