983 resultados para Henry II, King of England, 1133-1189.


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Planned to extend to 1660, but not completed beyond 1654.

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The life of the author, essay on his works, and criticism on his history are translated from the French of Jean Baptiste de La Curne de Sainte-Palaye.

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Reprint of the 1905-14 ed.

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"The present edition is confined to that portion of Wendover's chronicle which comprises the materials ... collected by himself" [i.e. 1154-1235]--Pref., v. 1.

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Vol. 4 has imprint: London, Printed for H. M. Stationery off., by Eyre and Spottiswoode.

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"A list of authorities": p. 627-29.

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A summary of the history of Engalnd, from the invasion of Julius Caesar to the death of George I: 274 p. at end of v. 4.

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Digital image

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AIMS: The aim of this article was to evaluate afatinib (BIBW 2992), an ErbB family blocker, and nintedanib (BIBF 1120), a triple angiokinase inhibitor, in castration-resistant prostate cancer patients.

PATIENTS & METHODS: Patients were randomized to receive nintedanib (250 mg twice daily), afatinib (40 mg once daily [q.d.]), or alternating sequential 7-day nintedanib (250 mg twice daily) and afatinib (70 mg q.d. [Combi70]), which was reduced to 40 mg q.d. (Combi40) due to adverse events. The primary end point was progression-free rate at 12 weeks.

RESULTS: Of the 85 patients treated 46, 20, 16 and three received nintedanib, afatinib, Combi40 and Combi70, respectively. At 12 weeks, the progression-free rate was 26% (seven out of 27 patients) for nintedanib, and 0% for afatinib and Combi40 groups. Two patients had a ≥50% decline in PSA (nintedanib and the Combi40 groups). The most common drug-related adverse events were diarrhea, nausea, vomiting and lethargy.

CONCLUSION: Nintedanib and/or afatinib demonstrated limited anti-tumor activity in unselected advanced castration-resistant prostate cancer patients.