Iowa Public Employees’ Retirement System Performance Report, FY2008

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2009

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2010

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2011

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2005

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2004

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2005

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2006

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Report, FY2007

Agency Performance Report

Iowa Public Employees’ Retirement System Performance Plan, FY2014

Agency Performance Plan, Iowa Public Employees’ Retirement System

Audit report of the Iowa Public Employees’ Retirement System (IPERS) as of June 30, 2013 and 2012

Audit report of the Iowa Public Employees’ Retirement System (IPERS) as of June 30, 2013 and 2012

Iowa Public Employees’ Retirement System An Annual Summary for the Fiscal Year Ended June 30, 2013, FY 2013

Report on the Iowa Public Employees’ Retirement System (IPERS) for the year ended June 30, 2013

Report on a review of selected general and application controls over the Iowa Public Employees’ Retirement System I-Que Pension Administration System for the period May 20, 2013 through July 12, 2013

Report on a review of selected general and application controls over the Iowa Public Employees’ Retirement System I-Que Pension Administration System for the period May 20, 2013 through July 12, 2013

High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.

Embryonic cells are expected to possess high growth/differentiation potential, required for organ morphogenesis and expansion during development. However, little is known about the intrinsic properties of embryonic epithelial cells due to difficulties in their isolation and cultivation. We report here that pure keratinocyte populations from E15.5 mouse embryos commit irreversibly to differentiation much earlier than newborn cells. Notch signaling, which promotes keratinocyte differentiation, is upregulated in embryonic keratinocyte and epidermis, and elevated caspase 3 expression, which we identify as a transcriptional Notch1 target, accounts in part for the high commitment of embryonic keratinocytes to terminal differentiation. In vivo, lack of caspase 3 results in increased proliferation and decreased differentiation of interfollicular embryonic keratinocytes, together with decreased activation of PKC-delta, a caspase 3 substrate which functions as a positive regulator of keratinocyte differentiation. Thus, a Notch1-caspase 3 regulatory mechanism underlies the intrinsically high commitment of embryonic keratinocytes to terminal differentiation.

Report of recommendations of the Iowa Public Employees’ Retirement System for the years ended June 30, 2013 and June 30, 2012

Report of recommendations of the Iowa Public Employees’ Retirement System for the years ended June 30, 2013 and June 30, 2012