Steel tubular products in general use as water-well pipe / c by H.L. Conklin.

Mode of access: Internet.

Transportability guidance : tube-launched, optically-tracked, wire-guided, heavy antitank/assault weapon system (TOW) : guided missile, surface attack, BGM-71-A (in shipping container) (FSN 1410-087-1521), launcher, tubular, guided missile, M220 (FSN 1440-179-4152), carrier, guided missile equipment ... truck ... training set ... shop equipment ... contact support ....

"September 1973."

Organizational, intermediate (field) (direct and general support) and depot maintenance repair parts and special tools list : generator set, gasoline engine driven, skid mounted, tubular frame, 10KW, AC, 120/208V, 3 phase and 120/240V, single phase, (less engine) : DoD model MEP-018A, MEP-023A, class utility, precise ... 6115-00-926-0843.

"June 1977."

Organizational, intermediate (field) (direct and general support) and depot maintenance repair parts and special tools list : generator set, gasoline engine driven, skid mounted, tubular frame, 3KW, 3 phase, AC, 120/208 and 120/240 volts, 28 VDC (less engine) : DoD model MEP-016A, MEP-021A, MEP-026A ... 6115-01-175-7320.

"Marine Corps stock list, SL-4-05926A."

Operator, organizational, intermediate (field) (direct support and general support) and depot maintenance manual : generator set, gasoline engine driven, skid mounted, tubular frame, 10 KW, AC, 120/208 V, 3 phase and 120/240 V, single phase - less engine : DoD model MEP-018A ....

"June 1977."

Operator, organizational, direct support, and general support maintenance manual : generator set, gasoline engine driven, skid mounted, tubular frame, 3 kw, 3 phase, AC, 120/208 and 120/240 volts, 28 V, DC (less engine) : DOD model MEP-016A ... hertz 60 ... NSN 6115-00-017-8237 ....

"August 1976."

Operator, organizational, intermediate (field), (direct support and general support), and depot level maintenance manual : generator set, tactical, gasoline engine, air cooled, 5 KW, AC, 120/240V single phase, 120/208V 3 phase, skid mounted, tubular frame (less engine) military design ; DoD model MEP-017A, MEP-022A, class utility ... 6115-00-017-8241.

"December 1977."

Organizational, intermediate (field), direct support and general support, maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) : generator set, gasoline engine : air cooled, 5 KW, AC, 120/240 V, single phase, 120/208V 3 phase skid mounted, tubular frame (less engine) military design : DoD model MEP-017A, MEP-022A ... 6115-00-017-8241.

"1 May 1986."

Organizational, intermediate (field) (direct support and general support) and depot maintenance repair parts and special tools list : generator set, gasoline engine driven, skid mounted, tubular frame, 1.5 KW, single phase, AC, 120/240 volts, 28 VDC (less engine) : DoD models MEP-015A ....

"1 May 1986."

Organizational, intermediate (field) (direct and general support), and depot maintenance repair parts and special tools list : generator set, gasoline engine driven, skid mounted, tubular frame, 10kw, AC, 120/208V, 3 phase and 120/240V, single phase, (less engine) : DOD model MEP-018A, MEP-023A, class utility, precise ... 6115-00-926-0843.

"June 1977."

Angiotensin II facilitates autoregulation in the perfused mouse kidney: An optimized in vitro model for assessment of renal vascular and tubular function

Background and Aims: We have optimized the isolated perfused mouse kidney (IPMK) model for studying renal vascular and tubular function in vitro using 24-28 g C57BL6J mice; the wild type controls for many transgenic mice. Methods and Results: Buffer composition was optimized for bovine serum albumin concentration (BSA). The effect of adding erythrocytes on renal function and morphology was assessed. Autoregulation was investigated during stepped increases in perfusion pressure. Perfusion for 60 min at 90-110 mmHg with Krebs bicarbonate buffer containing 5.5% BSA, and amino acids produced functional parameters within the in vivo range. Erythrocytes increased renal vascular resistance (3.8 +/- 0.2 vs 2.4 +/- 0.1 mL/min.mmHg, P < 0.05), enhanced sodium reabsorption (FENa = 0.3 +/- 0.08 vs 1.5 +/- 0.7%, P < 0.05), produced equivalent glomerular filtration rates (GFR; 364 +/- 38 vs 400 +/- 9 muL/min per gkw) and reduced distal tubular cell injury in the inner stripe (5.8 +/- 1.7 vs 23.7 +/- 3.1%, P < 0.001) compared to cell free perfusion. The IPMK was responsive to vasoconstrictor (angiotensin II, EC50 100 pM) and vasodilator (methacholine, EC50 75 nM) mediators and showed partial autoregulation of perfusate flow under control conditions over 65-85 mmHg; autoregulatory index (ARI) of 0.66 +/- 0.11. Angiotensin II (100 pM) extended this range (to 65-120 mmHg) and enhanced efficiency (ARI 0.21 +/- 0.02, P < 0.05). Angiotensin II facilitation was antagonized by methacholine (ARI 0.76 +/- 0.08) and papaverine (ARI 0.91 +/- 0.13). Conclusion: The IPMK model is useful for studying renal physiology and pathophysiology without systemic neurohormonal influences.

Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects

Relationships between cadmium (Cd) body burden, kidney function and coumarin metabolism were investigated using two groups of 197 and 200 healthy Thais with men and women in nearly equal numbers. A mean age of one group was 30.5 years and it was 39.3 years for the other group. Of 397, 20 subjects (5%) excreted urine Cd between 1.4 mug/g and 3.8 mug/g creatinine and these subjects faced 10-15% increase in the probability of having abnormal urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG-uria). The prevalence of NAG-uria varied with Cd body burden in a dose-dependent manner (chi(2) = 22, P < 0.008). Also NAG-nuria was one of the three kidney effect markers tested that showed the greatest strength of correlation with urine Cd in both men and women (r = 0.48 P < 0.001). In addition, urine Cd excretion of men and women showed a positive correlation (r = 0.46 to 0.54. P < 0.001) with urine 7-hydroxycoumarin (7-OHC) excretion which was used as a marker of liver cytochrome P450 2A6 (CYP2A6) enzyme activity. Urinary CA excretion accounted for 25% of the total variation in urine 7-OHC excretion (P < 0.001). These data suggest that Cd may increase the expression of CYP2A6 in liver, resulting in enhanced coumarin metabolism in subjects with high Cd body burden. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Pioglitazone increases renal tubular cell albumin uptake but limits proinflammatory and fibrotic responses

Background. Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. which are known to be critical factors in lipid metabolism, have also been reported to reduce proteinuria. The mechanism and its relevance to progressive nephropathy have not been determined. The aims of this study were to assess the direct effects of a PPARgamma agonist on tubular cell albumin uptake, proinflammatory and profibrotic markers of renal pathology, using an opossum kidney model of proximal tubular cells. Methods. Cells were exposed to pioglitazone (10 mumol/L) in the presence and absence of low-density lipoprotein (LDL) 100 mug/mL +/- exposure to albumin 1 mg/mL. Results were expressed relative to control (5 mmol/L glucose) conditions. Results. Pioglitazone caused a dose-dependent increase in tubular cell albumin uptake (P < 0.0001). Despite the increase in albumin reabsorption, no concurrent increase in inflammatory or profibrotic markers were observed. Exposure to LDL increased monocyte chemoattractant protein-1 (MCP-1) (P < 0.05) and transforming growth factor-beta1 (TGF-beta1) (P < 0.05) production. which were reversed in the presence of pioglitazone. LDL induced increases in MCP-1 and TGF-β1 were independent of nuclear factor-κB (NF-κB) transcriptional activity. In contrast. tubular exposure to albumin increased tubular protein uptake, in parallel with an increase in MCP-1 (P = 0.05): TGF-β1 (P < 0.02) and NF-kappaB transcriptional activity (P < 0.05). which were unaffected by concurrent exposure to pioglitazone. Conclusion. These findings suggest that dyslipidemia potentiates renal pathology through mechanisms that may be modified PPARγ activation independent of NF-κB transcriptional activitv. In contrast, tubular exposure to protein induces renal damage through NF-κB-dependent mechanisms that are Unaffected by PPARγ activation.