A reanalysis of 409 European-Ancestry and African American schizophrenia pedigrees reveals significant linkage to 8p23.3 with evidence of locus heterogeneity

The detection and replication of schizophrenia risk loci can require substantial sample sizes, which has prompted various collaborative efforts for combining multiple samples. However, pooled samples may comprise sub-samples with substantial population genetic differences, including allele frequency differences. We investigated the impact of population differences via linkage reanalysis of Molecular Genetics of Schizophrenia 1 (MGS1) affected sibling-pair data, comprising two samples of distinct ancestral origin: European (EA: 263 pedigrees) and African-American (AA: 146 pedigrees). To exploit the linkage information contained within these distinct continental samples, we performed separate analyses of the individual samples, allowing for within-sample locus heterogeneity, and the pooled sample, allowing for both within-sample and between-sample heterogeneity. Significance levels, corrected for the multiple tests, were determined empirically. For all suggestive peaks, stronger linkage evidence was obtained in either the EA or AA sample than the combined sample, regardless of how heterogeneity was modeled for the latter. Notably, we report genomewide significant linkage of schizophrenia to 8p23.3 and evidence for a second, independent susceptibility locus, reaching suggestive linkage, 29 cM away on 8p21.3. We also detected suggestive linkage on chromosomes 5p13.3 and 7q36.2. Many regions showed pronounced differences in the extent of linkage between the EA and AA samples. This reanalysis highlights the potential impact of population differences upon linkage evidence in pooled data and demonstrates a useful approach for the analysis of samples drawn from distinct continental groups.

Rabbi Leo Baeck's arrival at La Guardia Airport, New York from London for the Union of American Hebrew Congregations American Jewish Cavalcade Portraits; Groups

Sitting l-r Leo Baeck, Maurice N. Eisendrath, Oscar M. Lazrus; Standing l-r Jane Evans, Henry W. Levy, Saul Elgart, Rabbi Daniel L. Davis, Louis Rittenberg and Leonard H. Spring

A capability-based view of organisational renewal : Combining opportunity- and advantage-seeking growth in large, established European and North American wood-industry companies

The purpose of this study was to extend understanding of how large firms pursuing sustained and profitable growth manage organisational renewal. A multiple-case study was conducted in 27 North American and European wood-industry companies, of which 11 were chosen for closer study. The study combined the organisational-capabilities approach to strategic management with corporate-entrepreneurship thinking. It charted the further development of an identification and classification system for capabilities comprising three dimensions: (i) the dynamism between firm-specific and industry-significant capabilities, (ii) hierarchies of capabilities and capability portfolios, and (iii) their internal structure. Capability building was analysed in the context of the organisational design, the technological systems and the type of resource-bundling process (creating new vs. entrenching existing capabilities). The thesis describes the current capability portfolios and the organisational changes in the case companies. It also clarifies the mechanisms through which companies can influence the balance between knowledge search and the efficiency of knowledge transfer and integration in their daily business activities, and consequently the diversity of their capability portfolio and the breadth and novelty of their product/service range. The largest wood-industry companies of today must develop a seemingly dual strategic focus: they have to combine leading-edge, innovative solutions with cost-efficient, large-scale production. The use of modern technology in production was no longer a primary source of competitiveness in the case companies, but rather belonged to the portfolio of basic capabilities. Knowledge and information management had become an industry imperative, on a par with cost effectiveness. Yet, during the period of this research, the case companies were better in supporting growth in volume of the existing activity than growth through new economic activities. Customer-driven, incremental innovation was preferred over firm-driven innovation through experimentation. The three main constraints on organisational renewal were the lack of slack resources, the aim for lean, centralised designs, and the inward-bound communication climate.

Group portrait of the American Jewish Joint Distribution Committee; Shanghai Portraits; Groups

Photograph contained within portfolio including title page and signatures

Radio repair workshop; Juedische Winterhilfe der Juedische Gemeinde; Berlin Jewish Institutions

"300 Radioanlagen. 5000 Buecher"

Leo Baeck with Maurice N. Eisendrath, President of the Union of American Hebrew Congregations Portraits; Groups; Men

Page 24 of the "American Jewish Cavalcade" scrapbook of Leo Baeck in New York found in ROS 10 Folder 3

Leo Baeck with Maurice N. Eisendrath, President of the Union of American Hebrew Congregations Portraits; Groups; Men

Page 24 of the "American Jewish Cavalcade" scrapbook of Leo Baeck in New York found in ROS 10 Folder 3

Leo Baeck speaking, Maurice N. Eisendrath, President of the Union of American Hebrew Congregations, in background Portraits; Groups; Men

Page 23 of the "American Jewish Cavalcade" scrapbook of Leo Baeck in New York found in ROS 10 Folder 3

Leo Baeck with New York Mayor William O'Dwyer and Union of American Hebrew Congregations President Maurice N. Eisendrath, Oscar M. Lazrus and Rabbi Daniel L. Davis Portraits; Groups; Men

Page 12 of the "American Jewish Cavalcade" scrapbook of Leo Baeck in New York found in ROS 10 Folder 3

Multistation study of nighttime scintillations in low latitudes: Evidence of control by equatorial F region irregularities

VHF nighttime scintillations, recorded during a high solar activity period at a meridian chain of stations covering a magnetic latitude belt of 3°–21°N (420 km subionospheric points) are analyzed to investigate the influence of equatorial spread F irregularities on the occurrence of scintillation at latitudes away from the equator. Observations show that saturated amplitude scintillations start abruptly about one and a half hours after ground sunset and their onset is almost simultaneous at stations whose subionospheric points are within 12°N latitude of the magnetic equator, but is delayed at a station whose subionospheric point is at 21°N magnetic latitude by 15 min to 4 hours. In addition, the occurrence of postsunset scintillations at all the stations is found to be conditional on their prior occurrence at the equatorial station. If no postsunset scintillation activity is seen at the equatorial station, no scintillations are seen at other stations also. The occurrence of scintillations is explained as caused by rising plasma bubbles and associated irregularities over the magnetic equator and the subsequent mapping of these irregularities down the magnetic field lines to the F region of higher latitudes through some instantaneous mechanism; and hence an equatorial control is established on the generation of postsunset scintillation-producing irregularities in the entire low-latitude belt.

Early American Hanukkiya Coin

Silver 10 Lirot coin. Reverse: Early American Hanukkah Lamp.

Early American Hanukkiya Coin

Silver 10 Lirot coin. Obverse: marked with "Star of David" Reverse: Early American Hanukka Lamp.

Die Doppelgaengerin : Drama in fünf Bildern.

Drama about Hollywood writers, producers and actors, concerning the making and unmaking of the career of a young actress.

Seltsame Kaempfer der Neuzeit : Ein Essay und Hörspiel.

Annotated typescript of a radio play about Jewish history from 1492 to the 19th century; philosophers - Moses Mendelssohn and others - striving for right, justice, and humanity.

Board of Delegates of American Israelites records 1859-1881, 1887, 1932

Contains printed copies of the 1860 constitution and by-laws, copies of proceedings and annual reports, 1859-1877, of the Board of Delegates; report on Jews in Roumania, an 1874 annual report of the Hebrew Benevolent and Orphan Asylum Society, manuscript minute books and minutes of meetings, 1859-1876, resolutions, executive, financial, ritual slaughtering and other special committee reports, newspaper clippings and correspondence with synagogues and organizations in the U.S. who constitute the membership of the Board of Delegates, with the Union of American Hebrew Congregations with whom they later merged, the Union's Board of Delegates of Civil and Religious Rights, and with individuals and organizations in foreign countries including the Alliance Israelite Universelle, the Anglo-Jewish Association, the Board of Deputies of British Jews, the Committee for the Roumanian Jews (Berlin), the Koenigsberg Committee, and the London Roumanian Committee.