[1 lettre d'Auguste-Emmanuel Vaucorbeil à Jacques-Léopold Heugel (sans date)]

"On a versé sur moi, cher ami, tant de vilaines choses que les lettres ci-jointes sont une grande consolation. Peut-être pouvez-vous les publier?". - " Avez-vous vu Mlle [Gabrielle] Krauss?"

[1 lettre d'Auguste-Emmanuel Vaucorbeil à Jacques-Léopold Heugel (sans date).]

Mention de date : 3 juin, mais sans millésime. - Remercie son ami pour les renseignements apportés sur Jacques Roudil. Lui demande qu'il prenne en main "l'affaire Donadio" et l'informe qu'il sera probablement retenu par "l'affaire Gounod". Se montre très irrité au sujet de "F." avec qui il ira "jusqu'à la dernière limite de la patience": "je vous avoue que manquer à sa parole et ne pas même s'excuser, c'est beaucoup trop"

[1 lettre d'Auguste-Emmanuel Vaucorbeil à Jacques-Léopold Heugel (sans date)]

Remercie son ami pour son appréciation sur ses premières mélodies. Sollicite la publication de ses nouvelles mélodies "qui pourraient raviver les anciennes" et, ajoute-t-il, "vous retrouveriez [ainsi] votre ancien Schubert". - Se livre à des considérations générales sur les chanteurs "espèce singulière, en vérité, que les chanteurs, les plus ignorants des musiciens en général. Ne cherchant que l'effet connu, rabâché; n'appréciant que ce qu'ils comprennent sans étudier, je ne dis pas une heure, mais un moment. Par eux, l'art n'aurait pas fait un pas en avant : stationnaires et despotes. Le plus sage est donc de leur opposer une persévérance aussi opiniâtre que leur routine."

[1 lettre d'Auguste-Emmanuel Vaucorbeil à Jacques-Léopold Heugel (sans date)]

Fragment de lettre. - Demande à Heugel de compter M. Emile Gaudet parmi ses abonnés

[1 lettre d'Hannah Vaucorbeil à Jacques-Léopold Heugel (sans date)]

Mention de date : 2 février, mais sans millésime. Compte-tenu du très grand nombre de représentations de "Mignon" qui ont eu lieu à partir de 1866, il est impossible de dater avec plus de précison cette lettre. - Hannah Vaucorbeil est la belle-soeur d'Auguste-Emmanuel Vaucorbeil, directeur de l'Opéra. - Sollicite une loge à l'Opéra-Comique pour voir "Mignon" d'Ambroise Thomas

[6 lettres autographes signées de Jules Barbier à Henri Heugel (sans date)]

Rendez-vous divers, demandes d'argent.

Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease.

Although experimental studies have suggested that insulin-like growth factor I (IGF-I) and its binding protein IGFBP-3 might have a role in the aetiology of coronary artery disease (CAD), the relevance of circulating IGFs and their binding proteins in the development of CAD in human populations is unclear. We conducted a nested case-control study, with a mean follow-up of six years, within the EPIC-Norfolk cohort to assess the association between circulating levels of IGF-I and IGFBP-3 and risk of CAD in up to 1,013 cases and 2,055 controls matched for age, sex and study enrolment date. After adjustment for cardiovascular risk factors, we found no association between circulating levels of IGF-I or IGFBP-3 and risk of CAD (odds ratio: 0.98 (95% Cl 0.90-1.06) per 1 SD increase in circulating IGF-I; odds ratio: 1.02 (95% Cl 0.94-1.12) for IGFBP-3). We examined associations between tagging single nucleotide polymorphisms (tSNPs) at the IGF1 and IGFBP3 loci and circulating IGF-I and IGFBP-3 levels in up to 1,133 cases and 2,223 controls and identified three tSNPs (rs1520220, rs3730204, rs2132571) that showed independent association with either circulating IGF-I or IGFBP-3 levels. In an assessment of 31 SNPs spanning the IGF1 or IGFBP3 loci, none were associated with risk of CAD in a meta-analysis that included EPIC-Norfolk and eight additional studies comprising up to 9,319 cases and 19,964 controls. Our results indicate that IGF-I and IGFBP-3 are unlikely to be importantly involved in the aetiology of CAD in human populations.

Population specific and up to date cardiovascular risk charts can be efficiently obtained with record linkage of routine and observational data.

BACKGROUND: Only few countries have cohorts enabling specific and up-to-date cardiovascular disease (CVD) risk estimation. Individual risk assessment based on study samples that differ too much from the target population could jeopardize the benefit of risk charts in general practice. Our aim was to provide up-to-date and valid CVD risk estimation for a Swiss population using a novel record linkage approach. METHODS: Anonymous record linkage was used to follow-up (for mortality, until 2008) 9,853 men and women aged 25-74 years who participated in the Swiss MONICA (MONItoring of trends and determinants in CVD) study of 1983-92. The linkage success was 97.8%, loss to follow-up 1990-2000 was 4.7%. Based on the ESC SCORE methodology (Weibull regression), we used age, sex, blood pressure, smoking, and cholesterol to generate three models. We compared the 1) original SCORE model with a 2) recalibrated and a 3) new model using the Brier score (BS) and cross-validation. RESULTS: Based on the cross-validated BS, the new model (BS = 14107×10(-6)) was somewhat more appropriate for risk estimation than the original (BS = 14190×10(-6)) and the recalibrated (BS = 14172×10(-6)) model. Particularly at younger age, derived absolute risks were consistently lower than those from the original and the recalibrated model which was mainly due to a smaller impact of total cholesterol. CONCLUSION: Using record linkage of observational and routine data is an efficient procedure to obtain valid and up-to-date CVD risk estimates for a specific population.