[Treatment of uveitis-associated refractory ocular hypotony with topical ibopamine]

BACKGROUND: Ibopamine is a non-selective dopamine- and adrenalin-receptor agonist that has been shown to cause pupillary dilation and an increase in aqueous humour secretion. This novel drug can be used as a mydriatic agent, as a provocative test in open-angle glaucoma, and for the treatment of persisting ocular hypotony. HISTORY AND SIGNS: This 47-year-old man had a history of uveitis associated with Crohn's disease. Six years after deep sclerectomy for uveitic secondary glaucoma, he developed severe hypotony in his left eye with drop of visual acuity (VA). The hypotony did not respond to topical steroid treatment. 2 % Ibopamine solution was ordered t. i. d. concomitant to 1 % prednisolone acetate. THERAPY AND OUTCOME: Intraocular pressure (IOP) began to rise after 3 weeks of Ibopamine treatment and returned to normal (12 mmHg) with continuous recovery of VA after 8 weeks. Ibopamine was discontinued at an IOP of 16 mmHg after a course of 12 weeks. IOP and VA remained stable during the 12-month follow-up period. CONCLUSIONS: Ibopamine 2 % eye drops in combination with topical steroids are a therapeutic option in uveitis-associated ocular hypotony.

Antiproliferative effects of mistletoe (Viscum album L.) extract in urinary bladder carcinoma cell lines

BACKGROUND: The aim of the study was to evaluate the antiproliferative potency of Viscum album extract (VA-E) in human bladder carcinoma cell lines with regard to its possible use for intravesical therapy of superficial bladder cancer. MATERIALS AND METHODS: Proliferation (MTT-test or 3H-thymidine incorporation), necrotic disintegration (3H-thymidine release of prelabelled cells) and portions of apoptotic and/or necrotic cells (Annexin-V binding, propidium iodide (PI) labelling and DNA-fluorescence profiles by flow cytometry) were measured in four different human bladder carcinoma cell lines (T24, TCCSUP, J82 and UM-UC3) cultured in vitro. RESULTS: Antiproliferative effects of VA-E were observed in the four bladder carcinoma cell lines tested. Metabolic activity could also be completely abrogated by short-time contact of the cells with VA-E. Apoptosis and necrosis, as underlying mechanisms of action, were differentially expressed by the different cell lines. CONCLUSION: VA-E and cytotoxic proteins, i.e., mistletoe lectins (ML) and viscotoxins (VT), were able to block the growth of bladder carcinoma cells. Together with the immunomodulating properties of VA-E, the observed antiproliferative potency might give a rationale for the topical intravesical application of VA-E for the treatment of superficial bladder cancer.

A comparison of techniques for forecasting utilization of Veterans Affairs hospitals

This study demonstrated that accurate, short-term forecasts of Veterans Affairs (VA) hospital utilization can be made using the Patient Treatment File (PTF), the inpatient discharge database of the VA. Accurate, short-term forecasts of two years or less can reduce required inventory levels, improve allocation of resources, and are essential for better financial management. These are all necessary achievements in an era of cost-containment.^ Six years of non-psychiatric discharge records were extracted from the PTF and used to calculate four indicators of VA hospital utilization: average length of stay, discharge rate, multi-stay rate (a measure of readmissions) and days of care provided. National and regional levels of these indicators were described and compared for fiscal year 1984 (FY84) to FY89 inclusive.^ Using the observed levels of utilization for the 48 months between FY84 and FY87, five techniques were used to forecast monthly levels of utilization for FY88 and FY89. Forecasts were compared to the observed levels of utilization for these years. Monthly forecasts were also produced for FY90 and FY91.^ Forecasts for days of care provided were not produced. Current inpatients with very long lengths of stay contribute a substantial amount of this indicator and it cannot be accurately calculated.^ During the six year period between FY84 and FY89, average length of stay declined substantially, nationally and regionally. The discharge rate was relatively stable, while the multi-stay rate increased slightly during this period. FY90 and FY91 forecasts show a continued decline in the average length of stay, while the discharge rate is forecast to decline slightly and the multi-stay rate is forecast to increase very slightly.^ Over a 24 month ahead period, all three indicators were forecast within a 10 percent average monthly error. The 12-month ahead forecast errors were slightly lower. Average length of stay was less easily forecast, while the multi-stay rate was the easiest indicator to forecast.^ No single technique performed significantly better as determined by the Mean Absolute Percent Error, a standard measure of error. However, Autoregressive Integrated Moving Average (ARIMA) models performed well overall and are recommended for short-term forecasting of VA hospital utilization. ^

Proceedings of the Entomological Society of Philadelphia.

v. 3 (1864)

Conceptual Decolonization of Space: Worldview and Language in Anishinaabe Akiing

This dissertation examines the role of worldview and language in the cultural framework of American Indian people. In it I develop a theory of worldview which can be defined as an interrelated set of logics that orients a culture to space (land), time, the rest of life, and provides a prescription for understanding that life. Considering the strong links between language and worldview, it is methodologically necessary to focus on a particular language and culture to decolonize concepts of and relationships to land. In particular, this dissertation focuses on an Anishinaabe worldview as consisting of four components, which are; (1) an intimate relationship to a localized space; (2) a cyclical understanding of time; (3) living in a web of relatedness with all life, and (4) understanding the world around us in terms of balance. The methodological approach draws from Anishinaabemowin, the traditional Anishinaabe language, as a starting place for negotiating a linguistic-conceptual analysis of these logics to decolonize the understandings of land, time, relatedness and balance. This dissertation helps to demonstrate that the religious language as codified in the 1st Amendment to the United States Constitution as religious freedom is unable to carry the meaning of the fundamental relationships to land that are embedded in Anishinaabemowin and culture. I compare the above Anishinaabe worldview to that of the eurowestern culture in America, which is; (1) the domination of space; (2) a linear progression of time; (3) a hierarchical organization of life; and (4) understanding the world as a Manichean battle of good versus evil. This dissertation seeks to decolonize American Indian translational methodologies and undermine the assumptions of eurowestern cultural universality.

The European Resonance of Napoleon’s Defeat in Spain

The military event that sealed the defeat of Napoleon in Spain was the Battle of Vitoria on 21st June 1813, which saw the allied British, Spanish and Portuguese troops led by Wellington gain victory over Joseph Bonaparte's forces. It was the last great battle of what is known in Spain as the Guerra de la Independencia, in the United Kingdom as the Peninsular War and in France as the Guerre d'Espagne. While a sliver of Spanish territory remained under French control and the war itself went on for a few more months, it was the Battle of Vitoria that marked the end of Napoleon's rule on the Iberian Peninsula, as symbolised by the departure from Spain of Joseph Bonaparte, the monarch who had been imposed five years earlier to remove the Bourbons from the Spanish throne.

Journal of the British expedition from Detroit to Vincennes and its defeat by George Rogers Clark : manuscript, 1778-1782

Account of the British forces' expedition which captured Vincennes, Indiana in Dec. 1778, with an account of their eventual defeat in 1779 at the Battle of Vincennes by the American Revolutionary forces led by Col. George Rogers Clark.

Battlefield of Antietam, Sharpsburg, Maryland and vicinity, ca. 1862 (Raster Image)

This layer is a georeferenced raster image of the historic paper map: Map of the battlefield of Antietam, prepared by Wm. H. Willcox, Top. Off. & A.A.D.C. on Brig. Genl. Doubleday's staff from actual surveys ; J.G. Shoemaker, engr. 4th ed. It was published ca. 1862 by Lith. of P.S. Duval & Son. Scale [ca. 1:13,300]. Covers area in Washington County, Maryland including the Sharpsburg region and the Antietam National Battlefield. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System (in Meters) (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads and streets, houses, fences, vegetation, drainage, and artillery and Union and Confederate troop positions, and more. Relief shown by hachures. Includes inset: [Map of the environs of Sharpsburg]. This layer is part of a selection of digitally scanned and georeferenced historic maps of the Civil War from the Harvard Map Collection. Many items from this selection are from a collection of maps deposited by the Military Order of the Loyal Legion of the United States Commandery of the State of Massachusetts (MOLLUS) in the Harvard Map Collection in 1938. These maps typically portray both natural and manmade features, in particular showing places of military importance. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Across the reef: the Marine assault of Tarawa /

Shipping list no.: 93-0617-P.

Two medieval satires on the University of Paris: La bataille des vii ars of Henri d'Andeli, and the Morale scolarium of John of Garland.

Series note varies: At head of title of v. 1 and on verso of t.-p of v. 2, Memoirs of the University of California. v. 4, no. 1, 2. History, v. 1, no. 1, 2.

The literature of the nineteenth of April, 1775-1875.

Mode of access: Internet.

The campaign of Marengo, with comments,

Mode of access: Internet.

The Source of the Loue

Gustave Courbet; 3 ft. 3 1/4 in.x 4 ft. 7 63/64 in.; oil on canvas

The fighting bishop, John Strachan, first bishop of Toronto; and other essays in his times.

The fighting bishop.--The remarkable battle on Lake Erie.--The fight at Chateauguay.--Sir Francis Bond Head and the rebellion of '37.

San Jacinto, the sixteenth decisive battle,

Bibliography: 134-138.