The lauraceae collected in brazil by ludwig riedel - I

The species of Lauraceae collected by Ludwig Riedel, excluding Ocotea, are commented and contex-tualized according to the different itineraries he travelled in Brazil, from 1821 to 1836, indicating the localities and dates of collections, whenever possible. To complete this work, two diaries of Riedel have been consulted and the information from them cross-checked with the annotations found on specimen labels. An annotated list of 48 entries provides information on the status of species names and their types, currently accepted names, and collections found in different herbaria. Lectotypes for five names, Aydendron verrucosum var. attenuata, Aydendron parviflorum, Mespilodaphne parviflora, Nectandra spicata, and Oreodaphne fasciculata, are designated. The species of Ocotea collected by Riedel will be treated in part II of this series. © President and Fellows of Harvard College, 2012.

The lauraceae collected in brazil by ludwig riedel - II. Ocotea

The species of Ocotea (Lauraceae) collected by Ludwig Riedel are commented and contextualized according to the different itineraries he travelled in Brazil, from 1821 to 1836, indicating the localities and dates of collections, whenever possible. To complete this work, two diaries of Riedel have been consulted and the information from them crossed-checked with the annotations found on specimen labels. An annotated list of 44 entries provides information on the status of species names and their types, currently accepted names, and collections found in different herbaria. Lectotypes for 19 names are designated, two new synonyms are proposed, as well as the new combination Ocotea estrellensis (Meisn.) P.L.R. Moraes, based on Oreodaphne estrellensis Meisn. © President and Fellows of Harvard College, 2012.

Das neue digitale ‚Shakespeare-Bildarchiv Oppel-Hammerschmidt‘ an der Universitätsbibliothek Mainz : Reden und Beiträge anlässlich seiner öffentlichen Vorstellung am 17. November 2008 an der Johannes Gutenberg-Universität Mainz

On the basis of illustrations of Shakespeare's Hamlet, the new digital 'Oppel-Hammerschmidt Shakespeare Illustration Archive' at the Mainz University Library - together with a lavishly-constructed and multiply-linked Web interface version - was presented to the public on 17 November 2008. This e-book, edited by Andreas Anderhub and Hildegard Hammerschmidt-Hummel, contains the speeches and presentations given on the occasion of the opening ceremony of the electronic archive. The collection of the new archive, published here for the first time, holds about 3,500 images and is part of the only Shakespeare illustration archive in the world. The Shakespeare Illustration Archive was founded in 1946 by the internationally acclaimed Shakespeare and Goethe scholar, Prof. Horst Oppel. This part of the archive was donated to the Mainz University Library on condition that its holdings be digitalised and made available to the public. The collection has been named 'The Oppel-Hammerschmidt Shakespeare Illustration Archive' in accordance with the terms of the Agreement of Donation of 9, 15, and 16 September 2005, and honouring the 16 March 1988 Delegation of Authority and Declaration of Intent by Frau Ingeborg Oppel, Prof. Oppel's widow and legal assignee. Vice-President Prof. Jürgen Oldenstein opened the proceedings by noting that 2008 had been a good year for international Shakespeare scholarship. For, in London, the site of the 'Theatre' in Shoreditch, where Shakespeare's company performed, had been unearthed, and in Mainz the Shakespeare Archive had gone online with thousands of illustrations. The Dean of the Faculty of Philosophy and Philology, Prof. Mechthild Dreyer, who mentioned that she herself had long been successfully employing interdisciplinary research methods, took particular pleasure in the transdisciplinary approach to research resolutely pursued by Prof. Hammerschmidt-Hummel. Prof. Clemens Zintzen (Cologne), former President of the Mainz Academy of Literature and Sciences, recalled highlights from the more than sixty-year-long history of the Shakespeare Illustration Archive. Prof. Kurt Otten (Heidelberg and Cambridge) drew an impressive portrait of Horst Oppel's personality as an academic and praised his influential books on Goethe and Shakespeare. He pointed out that Oppel's Shakespeare Illustration Archive, the basis for many a dissertation, had enjoyed great popularity around the world. Prof. Otten also delineated the academic career of Prof. Hammerschmidt-Hummel and her new findings regarding Shakespeare's time, life and work. Prof. Rüdiger Ahrens OBE (Würzburg) drew attention to Prof. Hammerschmidt-Hummel's research results, directly or indirectly arising out of her work on the Shakespeare Illustration Archive. This research had centred on proving the authenticity of four visual representations of Shakespeare (the Chandos and Flower portraits, the Davenant bust and the Darmstadt Shakespeare death mask); solving the mystery around Shakespeare's 'Dark Lady'; and establishing the dramatist's Catholic religion. Prof. Hammerschmidt-Hummel reported on her 'Shakespeare Illustration' project, describing the nature, dimensions and significance of the Archive's pictorial material, which relates to all of Shakespeare's plays and stretches over five centuries. She explained that the digital 'Oppel-Hammerschmidt Illustration Archive' was an addition to the three-volume edition she had compiled, authored and edited for publication in 2003. Unlike the print version, however, the digital collection had only been partly editorially prepared. It represented source material and a basis for further work. Hammerschmidt-Hummel expressed her thanks to the Head of the Central University Library, Dr Andreas Anderhub, for his untiring commitment. After the initial donation had been made, he had entered enthusiastically into setting up the necessary contacts, getting all the work underway, and clearing the legal hurdles. Hammerschmidt-Hummel was especially grateful to University of Mainz librarian Heike Geisel, who had worked for nearly five years to carry out the large-scale digitalization of a total of 8,800 items. Frau Geisel was also extremely resourceful in devising ways of making the collection yield even more, e.g. by classifying and cross-linking the data, assembling clusters of individual topics that lend themselves to research, and (in collaboration with the art historian Dr Klaus Weber) making the archive's index of artists compatible with the data-bank of artists held by the University of Mainz Institute of Art History. In addition, she compiled an extremely helpful 'users' guide' to the new digital collection. Frau Geisel had enjoyed invaluable support from Dr Annette Holzapfel-Pschorn, the leading academic in the Central IT Department at the University, who set up an intelligent, most impressive Web interface using the latest application technologies. Frau Geisel and Dr Holzapfel-Pschorn were highly praised for their convincing demonstration, using illustrations to Hamlet, of how to access this well-devised and exceptionally user-friendly Web version. For legal reasons, Prof. Hammerschmidt-Hummel pointed out, the collection could not be released for open access on the internet. The media - as Dr Anderhub stressed in his foreword - had shown great interest in the new digital collection of thousands of Shakespearean illustrations (cf. Benjamin Cor's TV feature in "Tagesthemen", 17 November 2008, presented by Tom Buhrow). The ‘Oppel-Hammerschmidt Shakespeare Illustration Archive’ should also meet with particular interest not only among academic specialists, but also among the performers of the arts and persons active in the cultural realm in general, as well as theatre and film directors, literary managers, teachers, and countless Shakespeare enthusiasts.

Recuperare l'abitare sociale. Riqualificazione dell'edificio acer di via Wolfgang Goethe a Bologna.

Nel volume vengono proposte delle strategie di riqualificazione dell’edificio in via W. Goethe con numero civico 2-10 a Corticella zona Navile. L’edificio fa parte del quartiere PEEP realizzato a partire dagli anni ‘70 circa. L’intera area ricopre una superficie pari a 220.000 m2 di cui edificata 38.000 m2. Della superficie edificata ben 30.400 m2 è stata destinata al residenziale. A seguito delle evoluzioni economiche e sociali e alle restrizioni sempre più severe della normativa, il quartiere ha mostrato delle carenze e delle criticità: – Scarse prestazioni energetiche degli edifici con elevati costi di esercizio; – Inadeguata risposta alle azioni sismiche; – Tagli di alloggi non in grado di soddisfare l’odierna domanda; – Mancanza di efficaci spazi pubblici e di relazione; – Inefficace connessione urbana ai maggiori poli attrattivi e di circolazione. Come primo obbiettivo è stato affrontato il problema della mancanza di connessioni ciclopedonali adeguate al territorio di Corticella. Vi sono infatti alcune aree di nodale importanza che sono sprovviste di questi collegamenti rendendo difficoltoso il link tra i punti attrattivi fondamentali di Corticella e il nostro quartiere. Il progetto intende migliorare questo tipo di servizio in linea con il progetto “bike sharing & ride” promosso dalla Regione Emilia Romagna al fine di incentivare e promuovere la mobilità. Seguono poi gli interventi volti a risolvere le problematiche riscontrate nell’edificio. Interventi atti a riportare l’edificio in una condizione tale da renderlo adeguato alle necessità attuali e in grado di svolgere la sua funzione per gli anni a venire. Si tratta di strategie tecniche e parallelamente di strategie energetiche, con l’obbiettivo di definire spazi confortevoli all’interno degli alloggi. A tale fine sono state realizzate anche valutazioni sull’illuminazione naturale degli ambienti interni per valutare l’efficacia o meno del sistema utilizzato.

Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers

Chronic alcohol consumption is associated with an increased risk for upper aerodigestive tract cancer and hepatocellular carcinoma. Increased acetaldehyde production via alcohol dehydrogenase (ADH) has been implicated in the pathogenesis. The allele ADH1C*1 of ADH1C encodes for an enzyme with a high capacity to generate acetaldehyde. So far, the association between the ADH1C*1 allele and alcohol-related cancers among heavy drinkers is controversial. ADH1C genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism in a total of 818 patients with alcohol-associated esophageal (n=123), head and neck (n=84) and hepatocellular cancer (n=86) as well as in patients with alcoholic pancreatitis (n=117), alcoholic liver cirrhosis (n=217), combined liver cirrhosis and pancreatitis (n=17) and in alcoholics without gastrointestinal organ damage (n=174). The ADH1C*1 allele and genotype ADH1C*1/1 were significantly more frequent in patients with alcohol-related cancers than that in individuals with nonmalignant alcohol-related organ damage. Using multivariate analysis, ADH1C*1 allele frequency and rate of homozygosity were significantly associated with an increased risk for alcohol-related cancers (p<0.001 in all instances). The odds ratio for genotype ADH1C*1/1 regarding the development of esophageal, hepatocellular and head and neck cancer were 2.93 (CI, 1.84-4.67), 3.56 (CI, 1.33-9.53) and 2.2 (CI, 1.11-4.36), respectively. The data identify genotype ADH1C*1/1 as an independent risk factor for the development of alcohol-associated tumors among heavy drinkers, indicating a genetic predisposition of individuals carrying this genotype.

The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1

Abstract Context: Mammary and placental 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1). Objective: To assess the impact of testosterone, tibolone, and black cohosh on purified mammary and placental 17βHSD1. Materials and methods: 17βHSD1 was purified from human mammary gland and placenta by column chromatography, its activity was monitored by a radioactive activity assay, and the degree of purification was determined by gel electrophoresis. Photometric cofactor transformation analysis was performed to assess 17βHSD1 activity without or in presence of testosterone, tibolone and black cohosh. Results: 17βHSD1 from both sources displayed a comparable basal activity. Testosterone and tibolone metabolites inhibited purified mammary and placental 17βHSD1 activity to a different extent, whereas black cohosh had no impact. Discussion: Studies on purified enzymes reveal the individual action of drugs on local regulatory mechanisms thus helping to develop more targeted therapeutic intervention. Conclusion: Testosterone, tibolone and black cohosh display a beneficial effect on local mammary estrogen metabolism by not affecting or decreasing local estradiol exposure.

Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17/04): a randomised, international, multicentre phase 2 trial

BACKGROUND Postoperative hemithoracic radiotherapy has been used to treat malignant pleural mesothelioma, but it has not been assessed in a randomised trial. We assessed high-dose hemithoracic radiotherapy after neoadjuvant chemotherapy and extrapleural pneumonectomy in patients with malignant pleural mesothelioma. METHODS We did this phase 2 trial in two parts at 14 hospitals in Switzerland, Belgium, and Germany. We enrolled patients with pathologically confirmed malignant pleural mesothelioma; resectable TNM stages T1-3 N0-2, M0; WHO performance status 0-1; age 18-70 years. In part 1, patients were given three cycles of neoadjuvant chemotherapy (cisplatin 75 mg/m(2) and pemetrexed 500 mg/m(2) on day 1 given every 3 weeks) and extrapleural pneumonectomy; the primary endpoint was complete macroscopic resection (R0-1). In part 2, participants with complete macroscopic resection were randomly assigned (1:1) to receive high-dose radiotherapy or not. The target volume for radiotherapy encompassed the entire hemithorax, the thoracotomy channel, and mediastinal nodal stations if affected by the disease or violated surgically. A boost was given to areas at high risk for locoregional relapse. The allocation was stratified by centre, histology (sarcomatoid vs epithelioid or mixed), mediastinal lymph node involvement (N0-1 vs N2), and T stage (T1-2 vs T3). The primary endpoint of part 1 was the proportion of patients achieving complete macroscopic resection (R0 and R1). The primary endpoint in part 2 was locoregional relapse-free survival, analysed by intention to treat. The trial is registered with ClinicalTrials.gov, number NCT00334594. FINDINGS We enrolled patients between Dec 7, 2005, and Oct 17, 2012. Overall, we analysed 151 patients receiving neoadjuvant chemotherapy, of whom 113 (75%) had extrapleural pneumonectomy. Median follow-up was 54·2 months (IQR 32-66). 52 (34%) of 151 patients achieved an objective response. The most common grade 3 or 4 toxic effects were neutropenia (21 [14%] of 151 patients), anaemia (11 [7%]), and nausea or vomiting (eight [5%]). 113 patients had extrapleural pneumonectomy, with complete macroscopic resection achieved in 96 (64%) of 151 patients. We enrolled 54 patients in part 2; 27 in each group. The main reasons for exclusion were patient refusal (n=20) and ineligibility (n=10). 25 of 27 patients completed radiotherapy. Median total radiotherapy dose was 55·9 Gy (IQR 46·8-56·0). Median locoregional relapse-free survival from surgery, was 7·6 months (95% CI 4·5-10·7) in the no radiotherapy group and 9·4 months (6·5-11·9) in the radiotherapy group. The most common grade 3 or higher toxic effects related to radiotherapy were nausea or vomiting (three [11%] of 27 patients), oesophagitis (two [7%]), and pneumonitis (two [7%]). One patient died of pneumonitis. We recorded no toxic effects data for the control group. INTERPRETATION Our findings do not support the routine use of hemithoracic radiotherapy for malignant pleural mesothelioma after neoadjuvant chemotherapy and extrapleural pneumonectomy. FUNDING Swiss Group for Clinical Cancer Research, Swiss State Secretariat for Education, Research and Innovation, Eli Lilly.

17. Armee-Bulletin: General-Major v. Götz berichtet aus Mossocz vom 17. d. M., daß er nach Unterwerfung des ...

Welsch (Projektbearbeiter): Weiteres Vordringen der österreichischen Armee in Oberungarn (Slowakei). Nach siegreichem Gefecht bei Alsó-Turcsek (Turczek) sowie der Besetzung von Leutschau (Zips) Vorstoß von Eperies und Kaschau mit dem Ziel der Erreichung des Flusses Theiß

Dr. Ludwig Bamberger [Illustration] : Marmorbüste

Hugo Wolfgang Reinhold

Portraits junger Jüdinnen

Ludwig Strauß

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 17 - Antwortschreiben mit umfangreichen autobiographischen Angaben

Umzug nach Frankfurt am Main 1833; Erstbegegnung Anthime Gregoire de Blésimaires in Trittau; Cholera in Berlin; Kritik an der Regierung in Deutschland; Philosophie von Jean Paul; Johann Wolfgang von Goethe; weitere philosophische Veröffentlichungen nach "Die Welt als Wille und Vorstellung" von 1819; Alexander von Humboldt; Lehrtätigkeit als Professor an der Berliner Universität von 1820 bis 1831; zwischenzeitlicher Aufenthalt in Mannheim von 1831 bis 1833; Vorzüge von Frankfurt; Flötenspielerei; Sprachkenntnisse; kompliziertes Verhältnis zur in Bonn lebenden Mutter Johanna Schopenhauer;