Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.

"Snapshot" images of localized Ca2+ influx into patch-clamped chromaffin cells were captured by using a recently developed pulsed-laser imaging system. Transient opening of voltage-sensitive Ca2+ channels gave rise to localized elevations of Ca2+ that had the appearance of either "hotspots" or partial rings found immediately beneath the plasma membrane. When the Ca2+ imaging technique was employed in conjunction with flame-etched carbon-fiber electrodes to spatially map the release sites of catecholamines, it was observed that the sites of Ca2+ entry and catecholamine release were colocalized. These results provide functional support for the idea that secretion occurs from "active zone"-like structures in neuroendocrine cells.

Psicobiología del estrés prenatal:implicaciones en el eje hipotálamo-hipofisiario-adrenal de los bebés

The womb is the first developmental environment. After developmental psychobiologists started to investigate intrauterine evolution of infant and its long-term impact, they found that prenatal and postnatal development is influenced by mother’s psychological health. Specifically, scientific research evidence indicates that prenatal stress is a possible cause of subsequent psychopathological vulnerability. This vulnerability comes from stress sensitivity and is the basis of many childhood disorders. In the last decade, there are evidences for a fetal origin of stress sensitivity in the context of the fetal programming theory (Entringer et al., 2009, Grant et al., 2009, Gutteling et al., 2004, Huizink et al., 2004, O’Connor et al., 2005). According to fetal programming hypothesis, babies that have been exposed to high levels of prenatal stress would develop elevated HPA axis reactivity and thus increased stress sensitivity in the postnatal period. In the field of animal psychobiology, several studies have shown that prenatal stress could play some role on fetal programming of neurodevelopment and HPA axis (Glover, 2010, Weinstock, 2005, 2008). In human psychobiology, evidences are less clear (Glover, 2010). Although research in this regard has been growing during the last few years, more studies are warranted to investigate the relationship between maternal stress and fetal programming of neurodevelopment and the HPA axis in humans, to confirm the findings which are evident from animal psychobiology...

Medulla asceseos, seu, Exercitia Spiritualia S. P. Ignatii de Loyola /

"Accedit Triduum sacrum, omnium, præcipue religiosorum, usui accommodatum, una cum facili methodo expeditè meditandi."

Medulla chemiae /

Mode of access: Internet.

Sacrae theologiae moralis medulla recens ad mentem celeberrimorum P.P. Salmanticensium /

Mode of access: Internet.

Medulla theologiae moralis : facili ac perspicua methodo resoluens casus conscientiae /

Mode of access: Internet.

Sacrae theologiae moralis medulla recens ad mentem celeberrimorum Patrum Salmanticensium /

Mode of access: Internet.

He Kaine Diatheke = Novum testamentum graecum : ita adornatum ut in Textu Medulla Editonum probatarum retineatur, atque in Margine ad discernendas Lectiones genuinas, ancipites, sequiores, ania detur /

Mode of access: Internet.

Medulla Theologica : ex Sacris Scripturis, Conciliorum Pontificumque Decretis & Sanctorum Patrum ac doctorum placitis expressa ... /

Mode of access: Internet.

Medulla Theologica : ex Sacris Scripturis, Conciliorum Pontificumque decretis et sanctorum patrum ac doctorum placitis expressa /

Mode of access: Internet.

Conradi Victoris Schneideri ... Liber De nova gravissimorum trium morborum curatione : de apoplexia, cujus sedes non semper est cerebrum. Lipopsychia, quae non vitalis, sed animalis facultatis fractae symptoma est. Paralysi, cujus sedes non cerebrum, nec spinalis medulla nec nervus semper est ... Anacephalaeoses duae ...

Mode of access: Internet.

Medulla theologica ex Sacris Scripturis conciliorum, Pontificumque Decretis et Sanctorum Patrum ac doctorum placitis expressa ... /

Mode of access: Internet.

Medulla theologica ex Sacris Scripturis conciliorum, Pontificumque Decretis et Sanctorum Patrum ac doctorum placitis expressa ... /

Mode of access: Internet.

Medulla theologiae : pro triennali cursu in tres partes commode distributa ... /

Mode of access: Internet.

Medulla theologiae : pro triennali cursu in tres partes commode distributa ... /

Mode of access: Internet.