Long-term follow up (37-69 years) of patients with bladder exstrophy treated with ureterosigmoidostomy: uro-nephrological outcome

OBJECTIVE: To describe the urological and nephrological long-term outcome of patients born with classical bladder exstrophy treated with bilateral ureterosigmoidostomies in early childhood. PATIENTS AND METHOD: Out of 42 patients born with bladder exstrophy in Switzerland between 1937 and 1968, 25 participated in this study; seven had died, seven were lost to follow up and three refused consent. Assessment included chart review, clinical examination, and assessment of renal function and morphology. RESULTS: After a follow-up period of 37-69 years ((mean 50 years), 13 of the 25 participants (52%) had their ureterosigmoidostomy still in place. All others had different forms of urinary diversions. Fifteen (60%) patients had normal renal function or mild chronic kidney disease as assessed by estimated glomerular filtration rate. Three patients were on renal replacement therapy. MRI (n=16) showed 10 morphologically normal kidneys. One patient suffered from adenocarcinoma of the colon, five had benign colonic polyps, one urethral papillary carcinoma and 18 no evidence of tumor. CONCLUSION: The majority of our patients have normal or mildly impaired renal function and a well functioning ureterosigmoidostomy. This is remarkable, given the fact that ureterosigmoidostomies are considered to be refluxing high-pressure reservoirs at risk of renal injury and malignancy.

Google Images German Federal Court Entscheidung vom 29.04.2010, I ZR 69/08 With an English Introduction

The long-awaited verdict by the German Federal Court of Justice towards Google image search has drawn much attention to the problem of copyright infringement by search engines on the Internet. In the past years the question has arose whether the listing itself in a search engine like Google can be an infringement of copyright. The decision is widely seen as one of the most important of the last years. With significant amount of effort, the German Fede- ral Court tried to balance the interests of the right holders and those of the digital reality.

Predictors of adverse events among patients undergoing primary percutaneous coronary intervention: insights from a pooled analysis of the COMFORTABLE AMI and EXAMINATION trials

Aims: The aim of this study was to identify predictors of adverse events among patients with ST-elevation myocardial infarction (STEMI) undergoing contemporary primary percutaneous coronary intervention (PCI). Methods and results: Individual data of 2,655 patients from two primary PCI trials (EXAMINATION, N=1,504; COMFORTABLE AMI, N=1,161) with identical endpoint definitions and event adjudication were pooled. Predictors of all-cause death or any reinfarction and definite stent thrombosis (ST) and target lesion revascularisation (TLR) outcomes at one year were identified by multivariable Cox regression analysis. Killip class III or IV was the strongest predictor of all-cause death or any reinfarction (OR 5.11, 95% CI: 2.48-10.52), definite ST (OR 7.74, 95% CI: 2.87-20.93), and TLR (OR 2.88, 95% CI: 1.17-7.06). Impaired left ventricular ejection fraction (OR 4.77, 95% CI: 2.10-10.82), final TIMI flow 0-2 (OR 1.93, 95% CI: 1.05-3.54), arterial hypertension (OR 1.69, 95% CI: 1.11-2.59), age (OR 1.68, 95% CI: 1.41-2.01), and peak CK (OR 1.25, 95% CI: 1.02-1.54) were independent predictors of all-cause death or any reinfarction. Allocation to treatment with DES was an independent predictor of a lower risk of definite ST (OR 0.35, 95% CI: 0.16-0.74) and any TLR (OR 0.34, 95% CI: 0.21-0.54). Conclusions: Killip class remains the strongest predictor of all-cause death or any reinfarction among STEMI patients undergoing primary PCI. DES use independently predicts a lower risk of TLR and definite ST compared with BMS. The COMFORTABLE AMI trial is registered at: http://www.clinicaltrials.gov/ct2/show/NCT00962416. The EXAMINATION trial is registered at: http://www.clinicaltrials.gov/ct2/show/NCT00828087.

Zur Abwehr : Widerlegung der im Starkenburger Boten Nr. 92 (resp. Ausgab. Postztg.) u. 69 gegen das Judenthum erhobenen Beschuldigungen

von [Julius] Landsberger

Ms. hebr. oct. 69 - [Sammelband in 2 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 69 - De consonantia naturae et gratiae

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Antrag auf Ergreifung vorbereitender Maaßregeln zur Vermehrung der militärischen Macht in Deutschland, gestellt in der 69. Sitzung der Bundesversammlung am 5. Juli 1848

Boberach: Die Kontingente aller Bundesstaaten sollen ein Prozent der Bevölkerung bereithalten und innerhalb von sechs Wochen verdoppeln können, Landwehr sie ergänzen

Dr. Gottschalk van Geldern [Illustration] : Großvater Heinrich Heines, gest. 1793 im 69. Lebensjahre

Scan von Monochrom-Mikroform

Zu I. Groß' Artikel "Rochade und Notation bei Ibn Esra" [Nachricht] : M.G.W.J., Bd. 65, S. 365-69

Alexander Marx

Ms. germ. oct. 69 - Predigten zum Buch Samuel I, 1 - 15

Vorbesitzer: Bernhard Waldschmidt; alte Signatur: MS III,35;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 504 - Konzeptschreiben an den Dekan der Philiosophischen Fakultät der Universität Jena über den Inhalt seiner Dissertation "Über die vierfache Wurzel des Satzes vom zureichenden Grunde"

veröffentlicht in: Arthur Hübscher (Hrsg), Arthur Schopenhauer Gesammelte Briefe, Bonn 1978, Nr. 10