Ms. hebr. oct. 33 - [Sammelband in 4 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher

Synagogenordnungen der Synagoge am (vorw.) Börneplatz [5644 (1883/84) - 5693 (1932/33 ;] Geschenk und Sammlung von "Herrn Börsensensal Siegfried Herzfeld" an die Frankfurter Stadtbibliothek

In hebr. Schr.

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions

The barrier surfaces of the skin, lung, and intestine are constantly exposed to environmental stimuli that can result in inflammation and tissue damage. Interleukin (IL)-33-dependent group 2 innate lymphoid cells (ILC2s) are enriched at barrier surfaces and have been implicated in promoting inflammation; however, the mechanisms underlying the tissue-protective roles of IL-33 or ILC2s at surfaces such as the intestine remain poorly defined. Here we demonstrate that, following activation with IL-33, expression of the growth factor amphiregulin (AREG) is a dominant functional signature of gut-associated ILC2s. In the context of a murine model of intestinal damage and inflammation, the frequency and number of AREG-expressing ILC2s increases following intestinal injury and genetic disruption of the endogenous AREG-epidermal growth factor receptor (EGFR) pathway exacerbated disease. Administration of exogenous AREG limited intestinal inflammation and decreased disease severity in both lymphocyte-sufficient and lymphocyte-deficient mice, revealing a previously unrecognized innate immune mechanism of intestinal tissue protection. Furthermore, treatment with IL-33 or transfer of ILC2s ameliorated intestinal disease severity in an AREG-dependent manner. Collectively, these data reveal a critical feedback loop in which cytokine cues from damaged epithelia activate innate immune cells to express growth factors essential for ILC-dependent restoration of epithelial barrier function and maintenance of tissue homeostasis.

Höchst erbauliche und curiose Historia der schrecklichen Belagerung von Leipzig, im neunzehnten Jahrhundert, im 33. Jahre des dreiunddreißigjährigen Friedens : nach einer alten Chronik beschrieben und in zierliche Knittelverslein gebracht

Welsch (Projektbearbeiter): Spottgedicht auf den Verlauf der Revolution in Leipzig (März 1848)

Bericht der Fach-Kommission für Justiz-Reform über den Antrag der Abgeordneten Jacoby, Temme, und D'Ester sub Nr. 310, betreffend die Aufhebung der §§. 30 - 33. 36. 339. 940. Thl. II. Tit. 1. Allg. Landrecht: Nach den Bestimmungen des Allg. Landrechts, §. 30. bis 33., 36., 939. und 940., Thl. II., Tit. I. sind Ehen zwischen "Mannspersonen von Adel ...

Welsch (Projektbearbeiter): Einstimmige Annahme des Antrages zur Aufhebung des bestehenden Eheverbotes zwischen Adligen und Nichtadligen sowie Personen unterschiedlicher Konfession

Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects.

AIMS γ-Hydroxybutyrate (GHB) is used as a treatment for narcolepsy and alcohol withdrawal and as recreational substance. Nevertheless, there are limited data on the pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of GHB in humans. We characterized the pharmacokinetic profile and exposure-psychotropic effect relationship of GHB in humans. METHODS Two oral doses of GHB (25 and 35 mg/kg) were administered to 32 healthy male subjects (16 for each dose) using a randomized, placebo-controlled, cross-over design. RESULTS Maximal concentrations of GHB were (geometric mean and 95%CI): 218 (176-270) nmol/ml and 453 (374-549) nmol/ml for the 25 and 35 mg/kg GHB doses, respectively. The elimination half-lives (mean ± SD) were 36 ± 9 and 39 ± 7 min and the AUC∞ values (geometric mean and 95%CI) were 15,747 (12,854-19,290) and 40,113 (33,093-48,622) nmol∙min/ml for the 20 and 35 mg/kg GHB doses, respectively. Thus, plasma GHB exposure (AUC0-∞ ) rose disproportionally (+40%) with the higher dose. γ-Hydroxybutyrate produced mixed stimulant-sedative effects, with a dose-dependent increase in sedation and dizziness. It did not alter heart rate or blood pressure. A close relationship between plasma GHB exposure and its psychotropic effects was found, with higher GHB concentrations associated with higher subjective stimulation, sedation, and dizziness. No clockwise hysteresis was observed in the GHB concentration effect plot over time (i.e., no acute pharmacological tolerance). CONCLUSION Evidence was found of a non-linear dose-exposure relationship (i.e., no dose proportionality) at moderate doses of GHB. The effects of GHB on consciousness were closely linked to its plasma exposure and exhibited no acute tolerance. This article is protected by copyright. All rights reserved.

Kundmachung: Mateo Padovani, aus Triest gebürtig, 33 Jahre alt, israelitischer Religion ...

Welsch (Projektbearbeiter): Verurteilung des ehemaligen Versicherungsagenten Padovani (in Umwandlung einer zuvor ausgesprochenen Todesstrafe) zu zwölfjähriger Festungshaft wegen Aufruhrs

Kundmachung: Ludwig Ravaux, aus Köln in Preußen gebürtig, 33 Jahre alt, katholisch, verheirathet ...

Welsch (Projektbearbeiter): Verurteilung des Handelsagenten Ravaux (Raveaux?), des Buchbinders Schöninger sowie des ehemaligen preußischen Leutnants von Alvensleben (in Umwandlung der zuvor ausgesprochenen Todesstrafe) zu dreijähriger bzw. (im Falle von Alvenslebens) einjähriger Festungshaft wegen bewaffneten Widerstands gegen das Militär

33. Armee-Bulletin: Se. Durchlaucht der Feldmarschall Fürst zu Windischgrätz hatte in Erfahrung gebracht, daß sich bedeutende Streitkräfte der Rebellen ...

Welsch (Projektbearbeiter): Starke ungarische Verbände zwischen Gyöngyös und Hatvan; Gefechte bei Tápió-Bicske und Hatvan

The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice.

Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays a role in intestinal inflammation, yet its contribution to the pathogenesis of CRC is unknown. Using immunohistochemistry on 713 resected human CRC specimens, we show here that IL-33 and its receptor ST2 are expressed in low-grade and early-stage human CRCs, and to a lesser extent in higher-grade and more advanced-stage tumors. In a mouse model of CRC, ST2-deficiency protects from tumor development. Moreover, bone marrow (BM) chimera studies indicate that engagement of the IL-33/ST2 pathway on both the radio-resistant and radio-sensitive compartment is essential for CRC development. Mechanistically, activation of IL-33/ST2 signaling compromises the integrity of the intestinal barrier and triggers the production of pro-tumorigenic IL-6 by immune cells. Together, this data reveals a tumor-promoting role of IL-33/ST2 signaling in CRC.