Formação de um rebanho de corte utilizando novilhas cobertas aos 15 e 18 meses de idade.

Este trabalho visa orientar os produtores e técnicos que têm interesse em formar novos rebanhos com fêmeas acasaladas aos 15 ou 18 meses de idade. Tais orientações, no entanto, só serão válidas quando outros aspectos de manejo forem também observados, tais como: controle sanitário eficiente, estação de monta bem definida, controle adequado da qualidade e quantidade de pastagem disponível, etc.

Wokół pierwszego pobytu Apostoła Pawła w Efezie (Dz 18,18-22)

One of the crucial stages of the Apostle Paul’s ministry was his stay at Ephesus. However, considering the fact that the reliability of some data in the Acts of the Apostles on the time of Paul’s arrival to Ephesus is nowadays frequently put into question, it has become necessary to investigate the issue. In the present article the author assesses the relevant source material and takes a stand on the particular opinions of contemporary interpreters of the subject. Based on an analysis of the text of the Acts of the Apostles he is led to conclude that Luke’s account of Paul’s first short visit to Ephesus reveals traits of historicity.

Informe final de talleres sobre transferencia de tecnología para el aprovechamiento de la fibra de coco, desarrollo en las ciudades de Santa Marta y Cartagena de Indias entre el 18 y el 29 de septiembre de 2006, informe final.

[58] hojas : ilustraciones, fotografías.

Resolved Torsional Splittings in the ν18 and ν19- Bands of Propene

info:eu-repo/semantics/published

Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.

Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that loci on chromosomes 8, 11, and 18 influence susceptibility to S. aureus sepsis in A/J mice. We then used two candidate gene selection strategies to identify genes on these three chromosomes associated with S. aureus susceptibility, and targeted genes identified by both gene selection strategies. First, we used whole genome transcription profiling to identify 191 (56 on chr. 8, 100 on chr. 11, and 35 on chr. 18) genes on our three chromosomes of interest that are differentially expressed between S. aureus-infected A/J and C57BL/6J. Second, we identified two significant quantitative trait loci (QTL) for survival post-infection on chr. 18 using N(2) backcross mice (F(1) [C18A]xC57BL/6J). Ten genes on chr. 18 (March3, Cep120, Chmp1b, Dcp2, Dtwd2, Isoc1, Lman1, Spire1, Tnfaip8, and Seh1l) mapped to the two significant QTL regions and were also identified by the expression array selection strategy. Using real-time PCR, 6 of these 10 genes (Chmp1b, Dtwd2, Isoc1, Lman1, Tnfaip8, and Seh1l) showed significantly different expression levels between S. aureus-infected A/J and C57BL/6J. For two (Tnfaip8 and Seh1l) of these 6 genes, siRNA-mediated knockdown of gene expression in S. aureus-challenged RAW264.7 macrophages induced significant changes in the cytokine response (IL-1 beta and GM-CSF) compared to negative controls. These cytokine response changes were consistent with those seen in S. aureus-challenged peritoneal macrophages from CSS 18 mice (which contain A/J chromosome 18 but are otherwise C57BL/6J), but not C57BL/6J mice. These findings suggest that two genes, Tnfaip8 and Seh1l, may contribute to susceptibility to S. aureus in A/J mice, and represent promising candidates for human genetic susceptibility studies.

Environmental impacts of the coal ash spill in Kingston, Tennessee: an 18-month survey.

An 18 month investigation of the environmental impacts of the Tennessee Valley Authority (TVA) coal ash spill in Kingston, Tennessee combined with leaching experiments on the spilled TVA coal ash have revealed that leachable coal ash contaminants (LCACs), particularly arsenic, selenium, boron, strontium, and barium, have different effects on the quality of impacted environments. While LCACs levels in the downstream river water are relatively low and below the EPA drinking water and ecological thresholds, elevated levels were found in surface water with restricted water exchange and in pore water extracted from the river sediments downstream from the spill. The high concentration of arsenic (up to 2000 μg/L) is associated with some degree of anoxic conditions and predominance of the reduced arsenic species (arsenite) in the pore waters. Laboratory leaching simulations show that the pH and ash/water ratio control the LCACs' abundance and geochemical composition of the impacted water. These results have important implications for the prediction of the fate and migration of LCACs in the environment, particularly for the storage of coal combustion residues (CCRs) in holding ponds and landfills, and any potential CCRs effluents leakage into lakes, rivers, and other aquatic systems.

Results of the 1985 Excavations at Shiplap House (18AP30), 18 Pinkney Street, Annapolis, Maryland

The Shiplap House, 18AP30, located at 18 Pinkney Street, Annapolis, Maryland, was built ca. 1716. Located within the Historic District of Annapolis, Maryland (see Figures 2, 3, & 4 for site location within the Annapolis Historic District), the Shiplap House lies in immediate proximity to features of local and national importance. Due to its potential as a significant archaeological site, the Shiplap property was selected as one of the locations to be investigated during the 1985 summer Fieldschool in Urban Archaeology, a course offerred by the University of Maryland, College Park, under the direction of Dr. Mark P. Leone.

Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.

During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they lose their ability to respond to antigenic activation. Combinations of IL-12, IL-18, and IL-21 have been shown to induce the antigen-independent production of interferon (IFN)-γ by effector and memory CD8 T cells. In this study we investigated whether exhausted CD8 T cells are sensitive to activation by these cytokines. We show that effector and memory, but not exhausted, CD8 T cells produce IFN-γ and upregulate CD25 following exposure to certain combinations of IL-12, IL-18, and IL-21. The unresponsiveness of exhausted CD8 T cells is associated with downregulation of the IL-18-receptor-α (IL-18Rα). Although IL-18Rα expression is connected with the ability of memory CD8 T cells to self-renew and efflux rhodamine 123, the IL-18Rα(lo) exhausted cells remained capable of secreting this dye. To further evaluate the consequences of IL-18Rα downregulation, we tracked the fate of IL-18Rα-deficient CD8 T cells in chronically infected mixed bone marrow chimeras and discovered that IL-18Rα affects the initial but not later phases of the response. The antigen-independent responsiveness of exhausted CD8 T cells was also investigated following co-infection with Listeria monocytogenes, which induces the expression of IL-12 and IL-18. Although IL-18Rα(hi) memory cells upregulated CD25 and produced IFN-γ, the IL-18Rα(lo) exhausted cells failed to respond. Collectively, these findings indicate that as exhausted T cells adjust to the chronically infected environment, they lose their susceptibility to antigen-independent activation by cytokines, which compromises their ability to detect bacterial co-infections.

Reproduction of algebraic structures by 16-18 year old students

In this exploratory research we analyze the structure sense evidenced by 33 secondary students (16-18 years old) in tasks requiring to reproduce the structure of given algebraic expressions. The expressions used were algebraic fractions related to algebraic identities. There were big differences between the students performance which allowed differencing levels in students´ structure sense. Questions and conjectures to be addressed in future research are presented.

Nociones matemáticas adquiridas y audición diferenciada: edades 18-24 años

En este estudio, de orden cualitativo, se aplicó un cuestionario a 17 estudiantes con déficit auditivo, 18 a 24 años de edad, para obtener información sobre su comprensión de los números naturales, sus operaciones y sus relaciones básicas. Registrados en papel, los reactivos se presentaron en lengua escrita, con términos sencillos. Se prescindió de intérprete en la lengua de señas mexicana para identificar directamente posibles dificultades de comprensión de los conceptos matemáticos implicados; además, la aspiración de los participantes en el estudio al acceso a un bachillerato en línea impone su dominio de la lengua escrita. Los resultados indican el predominio de un razonamiento aditivo sobre el multiplicativo y, a lo más, una abstracción pseudoempírica en edades que en los normoyentes corresponden a las etapas del pensamiento formal. La escasa y deficiente producción en lengua escrita referida a los reactivos sugiere investigar el empleo del método de logogenia para su adquisición en conjunción con la del conocimiento matemático.

Imátgenes 16, 17 y 18

Hoy vengo a exponer una queja. Cada día, casi a todas horas, y, prácticamente en todo el mundo, soy maltratado. Y ese maltrato no es fruto del azar. Obedece patrones bien determinados de antemano por las voluntades de mis torturadores. Reconozco que a veces no es un maltrato auténtico y que incluso puede divertirme. Eso me mantiene en forma y me da un dinamismo que mi posición habitual no sugiere.

Códigos secretos: otra forma de aplicar las matrices en bachillerato (16-18)

Tras una breve introducción para hacer referencia a distintos tipos de códigos secretos, el articulo estudia con detalle, esquemáticamente y mediante ejemplos, los códigos matriciales. Se expone, además, una forma de automatizar dichos códigos en el aula, mediante un programa escrito en dBASE III Plus. La parte final consta de unas preguntas sobre sus posibilidades didácticas.

Pädagogisches Wissen in Bildern. Zum Bildprogramm der französischen Ausgaben des 18. Jahrhunderts von Rousseaus "Émile"

Aus Anlass der 250. Wiederkehr der Erstauflage von Rousseaus Werk "Émile oder über die Erziehung" widmet sich der Text der Analyse seiner Illustrationen. Die französischen Ausgaben des 18. Jahrhunderts wurden mit Kupferstichen von unterschiedlichen Künstlern gestaltet. Dabei war das Bildprogramm der Erstausgabe des Jahres 1762 noch von Rousseau autorisiert, während die posthumen Auflagen dies nicht mehr waren und einen vollständigen Wechsel des Bildprogramms vollziehen. Diese beiden unterschiedlichen Bildprogramme werden analysiert und in den Kontext ihrer Druckgeschichte gestellt. Dabei zeigt sich, auf welche Art das pädagogische Hauptwerk Rousseaus bildlich illustriert wird. (DIPF/Orig.)

[In Backpages 18.1] The culture of new writing

The influence of writing workshops on the content of plays is discussed.