972 resultados para 11,12-methylene-Hexadecanoic acid
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"15 February 1972."
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Mode of access: Internet.
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Mode of access: Internet.
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Item 1038-A, 1038-B (microfiche).
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Epidemiological studies previously identified cis-5,8,11,14,17-eicosapentaenoic acid (EPA) as the biologically active component of fish oil of benefit to the cardiovascular system. Although clinical investigations demonstrated its usefulness in surgical procedures, its mechanism of action still remained unclear. It was shown in this thesis, that EPA partially blocked the contraction of aortic smooth muscle cells to the vasoactive agents KCl and noradrenaline. The latter effect was likely caused by reducing calcium influx through receptor-operated channels, supporting a recent suggestion by Asano et al (1997). Consistently, EPA decreased noradrenaline-induced contractures in aortic tissue, in support of previous reports (Engler, 1992b). The observed effect of EPA on cell contractions to KCl was not simple due to blocking calcium influx through L-type channels, consistent with a previous suggestion by Hallaq et al (1992). Moreover, EPA caused a transient increase in [Ca2+]i in the absence of extracellular calcium. To resolve this it was shown that EPA increased inositol phosphate formation which, it is suggested, caused the release of calcium from an inositol phosphate-dependent internal binding site, possibly that of an intracellular membrane or superficial sarcoplasmic reticulum, producing the transient increase in [Ca2+]i. As it was shown that the cellular contractile filaments were not desensitised to calcium by EPA, it is suggested that the transient increase in [Ca2+]i subsequently blocks further cell contraction to KCl by activating membrane-associated potassium channels. Activation of potassium channels induces the cellular efflux of potassium ions, thereby hyperpolarising the plasma membrane and moving the membrane potential farther from the activation range for calcium channels. This would prevent calcium influx in the longer term and could explain the initial observed effect of EPA to block cell contraction to KCl.
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[...] J'ai toujours cru à l'importance de la lecture pour le développement d'un enfant et je me suis souvent interrogé sur ma propre approche pédagogique de la lecture. De plus, j'ai souvent constaté un certain désintéressement des jeunes vis-à-vis la lecture, effet probable d'une forte concurrence due à des activités qui captent plus leurs intérêts. Toujours est-il que désirant travailler dans ce domaine de la lecture, ne sachant trop quelles orientations donner à ce travail, j'ai entrepris une certaine réflexion avec mon directeur d'essai M. Raymond Hébert. Lors de discussions que je dirais orientées par M. Hébert, j'ai eu le goût d'approfondir ou même, jusqu'à un certain point, de découvrir les intérêts en lecture de mes propres élèves. Comme beaucoup de pédagogues, il ne m'était jamais venu à l'idée de chercher à savoir ce vers quoi s'orientent leurs goûts en lecture. Donc, dans ce travail, j'ai cherché à comprendre " l'enfant lecteur " que je côtoie quotidiennement. Je ne parle pas de techniques de lecture. Je ne cherche pas à corriger des lacunes ou encore à trouver des réponses à leur plus ou moins grand intérêt pour l'activité de lecture. J'ai voulu avant tout résoudre un problème bien précis pour moi, la connaissance des intérêts propres de mes élèves pour la lecture. Laissant de côté certaines intuitions quant aux intérêts des enfants en lecture, j'ai entrepris d'en faire une certaine analyse par une enquête la plus exhaustive possible auprès de quelques 64 élèves avec lesquels je travaille. Puis en deuxième partie, on trouvera un énoncé de principes qui devraient guider notre action pédagogique dans nos activités scolaires de lecture. De plus, ce qui m'a grandement aidé à mettre de l'ordre ou à clarifier mes idées, sont les nombreuses lectures suggérées par mon directeur d'essai. J'y ai trouvé une nouvelle vision du domaine de la lecture et surtout du phénomène complexe des motivations et besoins à lire chez l'enfant en développement.
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Cadastral survey map showing lot lines, lot nos., dimensions, acreages, and proposed streets.
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Shows recommended changes at the Childs Park recreation area within the N.R.A. on the Pa. side of the Delaware River.
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Concert Program
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The jasmonic acid (JA) pathway plays a central role in plant defense responses against insects. Some phloem-feeding insects also induce the salicylic acid (SA) pathway, thereby suppressing the plant’s JA response. These phenomena have been well studied in dicotyledonous plants, but little is known about them in monocotyledons. We cloned a chloroplast-localized type 2 13-lipoxygenase gene of rice, OsHI-LOX, whose transcripts were up-regulated in response to feeding by the rice striped stem borer (SSB) Chilo suppressalis and the rice brown planthopper (BPH) Niaparvata lugens, as well as by mechanical wounding and treatment with JA. Antisense expression of OsHI-LOX (as-lox) reduced SSB- or BPH-induced JA and trypsin protease inhibitor (TrypPI) levels, improved the larval performance of SBB as well as that of the rice leaf folder (LF) Cnaphalocrocis medinalis, and increased the damage caused by SSB and LF larvae. In contrast, BPH, a phloem-feeding herbivore, showed a preference for settling and ovipositing on WT plants, on which they consumed more and survived better than on as-lox plants. The enhanced resistance of as-lox plants to BPH infestation correlated with higher levels of BPH-induced H2O2 and SA, as well as with increased hypersensitive response-like cell death. These results imply that OsHI-LOX is involved in herbivore-induced JA biosynthesis, and plays contrasting roles in controlling rice resistance to chewing and phloem-feeding herbivores. The observation that suppression of JA activity results in increased resistance to an insect indicates that revision of the generalized plant defense models in monocotyledons is required, and may help develop novel strategies to protect rice against insect pests.