A-7 Statistical Report On FIP Applications And Cases Discontinued, November 2004

A-7 Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, December 2004

A-1 Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued, November 2004 (Revised)

Statistical Report On FIP Applications And Cases Discontinued

A-7 Statistical Report On FIP Applications And Cases Discontinued, December 2004

Statistical Report On FIP Applications And Cases Discontinued

A-7, Statistical Report On FIP Applications And Cases Discontinued, November 2004

Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, January 2005

A1-Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued, January 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, February 2005

Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued, February 2005

Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, March 2005

A-1 Monthly Public Assistance Statistical Report Family Investment Program

Suitability of GRIND-based principal properties for the description of molecular similarity and ligand-based virtual screening

The information provided by the alignment-independent GRid Independent Descriptors (GRIND) can be condensed by the application of principal component analysis, obtaining a small number of principal properties (GRIND-PP), which is more suitable for describing molecular similarity. The objective of the present study is to optimize diverse parameters involved in the obtention of the GRIND-PP and validate their suitability for applications, requiring a biologically relevant description of the molecular similarity. With this aim, GRIND-PP computed with a collection of diverse settings were used to carry out ligand-based virtual screening (LBVS) on standard conditions. The quality of the results obtained was remarkable and comparable with other LBVS methods, and their detailed statistical analysis allowed to identify the method settings more determinant for the quality of the results and their optimum. Remarkably, some of these optimum settings differ significantly from those used in previously published applications, revealing their unexplored potential. Their applicability in large compound database was also explored by comparing the equivalence of the results obtained using either computed or projected principal properties. In general, the results of the study confirm the suitability of the GRIND-PP for practical applications and provide useful hints about how they should be computed for obtaining optimum results.

A-7 Statistical Report On FIP Applications And Cases Discontinued, March 2005

A-7 Statistical Report On FIP Applications And Cases Discontinued

A-1 Monthly Public Assistance Statistical Report Family Investment Program, April 2005

Monthly Public Assistance Statistical Report Family Investment Program

A-1 Monthly Public Assistance Statistical Report Family Investment Program, May 2005

Monthly Public Assistance Statistical Report Family Investment Program

A-7 Statistical Report On FIP Applications And Cases Discontinued April 2005

Statistical Report On FIP Applications And Cases Discontinued