Weekly Self-Scheduling, Forward Contracting, and Offering Strategy for a Producer

Within a weekly market horizon, this paper considers a power producer that sells its energy both in the pool and through weekly forward contracts. The paper provides a methodology that allows the producer to derive the self-scheduling of its production units, to select weekly forward contracts, and to obtain the offering strategy for Monday's pool. The proposed technique is based on stochastic programming and allows the producer to maximize its expected profit while controlling the risk of profit variability. A comprehensive case study is used to illustrate the characteristics of the proposed methodology. Appropriate conclusions are finally drawn.

As crônicas de Bilac nas revistas ilustradas A cigarra (1895) e A Bruxa (1896-1897)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A Semana: periódico literário

A vinda da família real para o Brasil, em 1808, trouxe grandes mudanças e entre elas a primeira manifestação periódica o Correio Brasiliense, editado em Londres. No início do século XX, sobretudo, com a Semana de Arte Moderna em 1922, surgem revistas como: Klaxon, Estética, Festa e outras. A partir delas editam-se outras que constituíram importantes documentos da sociedade brasileira e registram a nova tendência do público leitor. O Pará não ficou ausente desses acontecimentos e teve a Imprensa como seu principal veículo de divulgação. Algumas revistas e alguns jornais surgiram nessa época na capital do Estado, entre as quais se destacou a revista A Semana, que circulou por vinte e cinco anos. Esse semanário mantinha correspondência com outras regiões do Brasil: São Paulo, Rio de Janeiro, Recife, Maranhão. Nessas regiões havia colaboradores da revista, o que permitia a troca de informações do que acontecia no mundo literário e no mundo cultural. Dos periódicos compilados foram selecionados quatro exemplares do ano de 1939 para serem estudados, neste trabalho. Neles foram feitos levantamentos da capa, das publicações literárias, do gênero a que essas produções pertenciam e de seus respectivos autores. Pelo quadro-resumo feito dessas edições, percebeu-se que os editores procuravam seguir um padrão divulgando textos de cunho literário, como contos, poemas, trechos de romances, ensaios, entre outros. Em algumas dessas produções ficaram evidentes que nem todas absorveram a nova tendência estética que veio com A Semana de Arte Moderna, pois havia escritores que oscilavam entre as estéticas Romântica, Simbolista e Parnasiana. Por outro lado existiam aqueles que se destacavam, incorporando esse novo tempo literário. Em meio a essas produções despontava a figura feminina, num lugar de destaque, que além de ilustrarem a capa do periódico ainda apareciam nas páginas subseqüentes. Todas essas informações divulgadas no periódico deram mais credibilidade à Revista e permitiu que a Literatura Paraense fizesse parte desse novo momento da Literatura Brasileira.

Petroleum products biodegradation profile similarity evaluated by F test comparison of weekly CO2 production

Strategies applied to bioremediation contaminated environments are necessary to identify limitations towards biodegradation and to predict remediation performance and thereby rule out technologies that may be inappropriate for the clean-up of the substances of concern. Respirometry applied to bioremediation offers a series of advantages for obtaining CO2 production data when compared to other procedures. It was possible to determinate information regarding the atmosphere's CO2 concentration inside a respirometer containing petroleum products. Afterwards, the CO2 data obtained underwent an in depth statistical analysis by F test. There are some noticeable biodegradation similarity among some substances, such as weathered motor oil and gasoline. Such data provides reliability when revealing important information about how the biodegradation processes happens in those residual oils.

Os recursos publicitários como ferramenta de valorização do fazer-jornalístico: um estudo das capas da Revista Veja

This study focuses on an analysis of the convergence of Journalism and Publicity on the covers of the magazine. This paper aims to clarify how the dynamics of that relationship, understanding that in contemporary society, both Journalism and Publicity to perform the same function-to inform, differing only in the objective-journalism sells news, Publicity sells dream. The magazine Veja was chosen for this study because its importance and scope in publishing. Inspired by Time magazine, founded in 1922 by Henry Luce, Veja was the 2nd review of gender information in Brazil. Today a record run of more than 1 million copies, occupying the 3rd position in the ranking of news magazines sold over the world and the largest weekly magazine of the U.S. Among the media, the magazine is the most identified with the publicity, because as disseminator of advertising, the magazine has the advantage of being able to achieve precisely the widest range of public and the possibility of dealing with many different subjects; In addition, the number of people who have contact with the advertising is much greater because, on average, four people read each issue and is also common that the same reader review the revised more than once, which helps in setting the message advertising. This affinity between magazine and publicity is in its essence as both are prepared for the market, seek to promote, show themselves to be bought. Accordingly, we intend to find out how media discourse of Veja and publicity, approach in the writing of magazine covers

Weekly Problems Scales: Instruments for Sexually Abused Youth and Their Nonoffending Parents in Treatment

This study’s purpose was to determine if efficient measures could be created to assess multiple problematic behaviors identified in youth who were sexually abused and in treatment. Because of the lack of easily administered brief instruments that assess multiple domains of interest in this population, complementary parent and child assessment measures were developed. The Weekly Problems Scale–Child Version (WPSC) and the Weekly Problems Scale–Parent Version (WPS-P) were created to monitor the weekly progress of the child and family in treatment and focus specifically on common areas of difficulties in this population. Exploratory factor analysis was conducted to assist in identifying the number of underlying dimensions in the scales. Results indicate that the WPS-C and WPS-P demonstrate adequate internal consistency, temporal stability, and construct validity. The WPS-C and WPSP display significant promise as research and clinical assessment tools for use with youth who are sexually abused and their nonoffending parents in treatment.

Exercise training program based on minimum weekly frequencies: effects on blood pressure and physical fitness in elderly hypertensive patients

Background: Exercise training (ET) can reduce blood pressure (BP) and prevent functional disability. However, the effects of low volumes of training have been poorly studied, especially in elderly hypertensive patients. Objectives: To investigate the effects of a multi-component ET program (aerobic training, strength, flexibility, and balance) on BP, physical fitness, and functional ability of elderly hypertensive patients. Methods: Thirty-six elderly hypertensive patients with optimal clinical treatment underwent a multi-component ET program: two 60-minute sessions a week for 12 weeks at a Basic Health Unit. Results: Compared to pre-training values, systolic and diastolic BP were reduced by 3.6% and 1.2%, respectively (p < 0.001), body mass index was reduced by 1.1% (p < 0.001), and peripheral blood glucose was reduced by 2.5% (p= 0.002). There were improvements in all physical fitness domains: muscle strength (chair-stand test and elbow flexor test; p < 0.001), static balance test (unipedal stance test; p < 0.029), aerobic capacity (stationary gait test; p < 0.001), except for flexibility (sit and reach test). Moreover, there was a reduction in the time required to perform two functional ability tests: "put on sock" and "sit down, stand up, and move around the house" (p < 0.001). Conclusions: Lower volumes of ET improved BP, metabolic parameters, and physical fitness and reflected in the functional ability of elderly hypertensive patients. Trial Registration RBR-2xgjh3.

Combination of bevacizumab and 2-weekly pegylated liposomal doxorubicin as first-line therapy for locally recurrent or metastatic breast cancer. A multicenter, single-arm phase II trial (SAKK 24/06)

pegylated liposomal doxorubicin (PLD) and bevacizumab are active agents in the treatment of metastatic breast cancer (MBC). We carried out a multicenter, single-arm phase II trial to evaluate the toxicity and efficacy of PLD and bevacizumab as first-line treatment in MBC patients.

Efficacy and tolerability of capecitabine with weekly paclitaxel for patients with metastatic breast cancer: a phase II report of the SAKK

BACKGROUND: Paclitaxel and capecitabine have proven activity in the treatment of metastatic breast cancer (MBC). Paclitaxel increases the expression of thymidine phosphorylase, the enzyme that activates capecitabine. The purpose of this study was to evaluate the efficacy and tolerability of capecitabine in combination with weekly paclitaxel largely as first-line therapy in patients with MBC. PATIENTS AND METHODS: From April 2002 to September 2004, 19 patients with MBC received oral capecitabine (1,000 mg/m(2) twice daily on days 1-14) plus i.v. paclitaxel (80 mg/m(2) on days 1, 8 and 15) in a 21-day cycle for a maximum of 6 cycles. RESULTS: After a median follow-up of 19.3 months the overall response rate was 63% with 1 complete response (5%) and 11 partial responses (58%). Disease was stabilized in 1 patient (5%) and 3 patients had progressive disease (16%). Three patients were unable to be assessed for response to treatment. Median time to progression was 3.3 months, median time to treatment failure 3.0 months and median overall survival 13.8 months. A substantial number of patients experienced major side effects. The most common treatment-related adverse events were hand-foot syndrome (53%; grade 3: 37%), alopecia (42%; grade 3: 26%), diarrhea (32%; grade 3: 11%) and neurotoxicity (32%; grade 3: 16%). Hematologic toxicities were uncommon. CONCLUSION: The combination of capecitabine and paclitaxel appears to be active in MBC but the safety profile with the dosages used in this trial was unacceptably high and led to a short time to treatment failure. However, based on the efficacy data alternative schedules deserve further evaluation.

A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major

BACKGROUND AND OBJECTIVES: The aim of this prospective, randomized, 1-year study was to compare the efficacy and safety of oral deferiprone (DFP) with those of combinations of parenteral desferrioxamine (DFO) with oral DFP. DESIGN AND METHODS: A total of 24 patients with thalassemia major were randomized to receive one of the following two treatments; DFP given at a daily dose of 75 mg/kg in combination with DFO (40-50 mg/kg twice weekly) (n=12) or as single agent (n=12). In addition, 12 patients treated with 40-50 mg/kg DFO 5 days weekly were included as a reference group without randomization. Changes in liver iron concentration (LIC) and serum ferritin (SF) were assessed; total iron excretion (TIE), urinary iron excretion (UIE) and iron balance were calculated. Cardiac function and toxicity were also examined. DESIGN AND METHODS: SF and LIC were significantly reduced after 1 year of combination therapy (p=0.01 and 0.07, respectively). A decrease of LIC was observed in all but one patient (87.5%) following the combination therapy but in only 42% of patients treated with DFP monotherapy. In the DFO reference group, a statistically significant decrease in LIC (p=0.01) associated with a substantial decrease in SF (p=0.08) was observed after 1 year. The combination regimen resulted in greater TIE compared to DFP monotherapy (p=0.08) and was the regimen associated with the highest iron balance compared to DFP monotherapy (p=0.04) or standard DFO treatment (p=0.006). INTERPRETATIONS AND CONCLUSIONS: The addition of subcutaneous DFO twice weekly to oral DFP 75 mg/kg is a highly efficacious and safe chelation therapy providing superior chelation activity to that of DFP and likely has an efficacy profile comparable to that of standard DFO.

Randomized trial of daily versus weekly administration of 2-chlorodeoxyadenosine in patients with hairy cell leukemia: a multicenter phase III trial (SAKK 32/98)

Daily administration of 2-chlorodeoxyadenosine (Cladribine, CDA) is a standard treatment for hairy cell leukemia, but may cause severe neutropenia and neutropenic fever. This trial compared toxicity and efficacy of weekly versus daily CDA administration. One hundred patients were randomized to receive standard (CDA 0.14 mg/kg/day day 1-5 [Arm A]) or experimental treatment (CDA 0.14 mg/kg/day once weekly for 5 weeks [Arm B]). The primary endpoint was average leukocyte count within 6 weeks from randomization. Secondary endpoints included response rates, other acute hematotoxicity, acute infection rate, hospital admission, remission duration, event-free, and overall survival. There was no significant difference in average leukocyte count. Response rate (complete + partial remission) at week 10 was 78% (95% confidence interval (CI) 64-88%) in Arm A and 68% (95% CI 54-80%) in Arm B (p = 0.13). Best response rates during follow-up were identical (86%) in both arms. No significant difference was found in the rate of grade 3+4 leukocytopenia (94%vs. 84%), grade 3+4 neutropenia (90%vs. 80%), acute infection (44%vs. 40%), hospitalization (38%vs. 34%), and erythrocyte support (22%vs. 30%) within 10 weeks. Overall, these findings indicate that there are no apparent advantages in toxicity and efficacy by giving CDA weekly rather than daily.