Efeitos da inibição prolongada da enzima de conversão da angiotensina sobre as características morfológicas e funcionais da hipertrofia ventricular esquerda em ratos com sobrecarga pressórica persistente

OBJETIVO: Avaliar os efeitos do lisinopril (L) sobre as taxas de mortes (M), insuficiência cardíaca (ICC), características da remodelação miocárdica, geométrica e funcional do ventrículo esquerdo (VE), em ratos com estenose aórtica supravalvar (EAS). MÉTODOS: Ratos foram submetidos a EAS ou cirurgia simulada (GC:n=10). Randomizados após 6 semanas para receber L (GL:n=30) ou nenhum tratamento (GE:n=73) sendo avaliados 6s e 21s por estudos ecocardiográfico, hemodinâmico e morfológico concomitantes. RESULTADOS: As taxas de M (GE: 53,9% vs GL: 16,7% e ICC GE: 44,8% vs GL: 20% p<0,05). No final do experimento, os valores da pressão sistólica do VE dos grupos GE e GL foram equivalentes e significantemente mais elevados do que no grupo GC; (p<0,05) não diferindo dos observados 6 semanas após os procedimentos cirúrgicos. Os valores da pressão diastólica do VE no grupo GE foram maiores do que os do grupo GL (p<0,05) sendo ambos maiores do que os do grupo GC (4 ± 2 mmHg, p<0,05). O mesmo comportamento foi observado com as variáveis: razão E/A; índice de massa, área seccional dos miócitos e conteúdo de hidroxiprolina do VE. A porcentagem de encurtamento do VE foi semelhante nos grupos GC e GL (p>0,05) sendo ambos maiores que os verificados no grupo GE. Comportamento semelhante foram obtidos com os valores da primeira derivada positiva e negativa da pressão do VE. CONCLUSÃO: em ratos com EAS o L reduziu as taxas de M e ICC e exerceu efeitos benéficos sobre a remodelação e a função do VE.

Tratamento de insuficiência cardíaca com benazepril em cães com cardiomiopatia dilatada e endocardiose

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Uniconazole on mango floral induction cultivar 'Kent' at submedio são francisco region, Brazil

In order to provide efficient crop management which enables the scaling of the production of mango in semi-arid conditions and achieve a greater precision in the recommendation, evaluating the effect and the influence of uniconazole foliar spray, on the emission of vegetative flushes in the cultivar 'Kent', field tests were carried out in a productive orchard. Treatments tested were three uniconazole dosages, 500, 1,000 and 1,500 mg L-1, with one, two or three respective foliar sprayings. Another treatment with paclobutrazol was used at 2.0 g a.i./m of canopy diameter, with a single application via soil and a control (without spraying of plant growth regulators), where spreader-sticker was added and the pH was adjusted. With 30, 60 and 90 days after the first spraying of the flowering inducer the growth of branches were evaluated, as well as the percentage of flowering in all treatments after 120 days of first spraying. The sprayings started in the orchard after the emission of the second vegetative flush after pruning of production, through airassisted sprayer with flow rate of 1,000 L ha-1. The experimental design was done through randomized blocks with four replications, using three plants per plot. It was observed that paclobutrazol was significantly highlighted in relation to other treatments and that the uniconazole with one, two and three foliar sprayings presented inhibition of the vegetative growth in mango 'Kent' and showed, even at low proportions, signs of flowering.

Partial external mitral annuloplasty in dogs with myxomatous mitral valve degeneration and congestive heart failure: Outcome in 9 cases

Objective: To report the outcome of partial external mitral annuloplasty in dogs with congestive heart failure (CHF) due to mitral regurgitation caused by myxomatous mitral valve degeneration (MMVD). Animals, materials and methods: Nine client-owned dogs with CHF due to mitral regurgitation caused by MMVD. Surgery consisted of a double row of pledget-butressed continuous suture lines placed into the left ventricle parallel and just ventral to the atrioventricular groove between the subsinuosal branch of the left circumflex coronary artery and the paraconal branch of the left coronary artery. Results: Two dogs died during surgery because of severe hemorrhage. Two dogs died 12 and 36 h after surgery because of acute myocardial infarction. Three dogs were euthanized 2 and 4 weeks after surgery because of progression of CHF, 1 was euthanized 30 days after surgery for non-cardiac disease, and 1 survived for 48 months. In the 5 dogs that survived to discharge there was no significant change in the left atrium to aortic ratio with surgery (3.6 ± 0.56 before surgery; 3.1 ± 0.4 after surgery; p = 0.182), and no significant change in mitral regurgitant fraction in 4 dogs in which this measurement was made (78.7 ± 2.0% before surgery; 68.7 ± 7.5% after surgery; p = 0.09). Conclusions: Partial external mitral annuloplasty in dogs with CHF due to MMVD was associated with high perioperative mortality and most dogs that survived to discharge failed to show clinically relevant palliation from this procedure. Consequently, partial external mitral annuloplasty is not a viable option for dogs with mitral regurgitation due to MMVD that has progressed to the stage of CHF. © 2011 Elsevier B.V. All rights reserved.

Charged particle transverse momentum spectra in pp collisions at √s = 0:9 and 7 TeV

The charged particle transverse momentum (pT) spectra are presented for pp collisions at √s = 0:9 and 7TeV. The data samples were collected with the CMS detector at the LHC and correspond to integrated luminosities of 231 μb-1 and 2.96 pb-1, respectively. Calorimeter-based high-transverse-energy triggers are employed to enhance the statistical reach of the high-pT measurements. The results are compared with leading and next-toleading order QCD and with an empirical scaling of measurements at different collision energies using the scaling variable xT - 2pT=ps over the pT range up to 136 GeV/c. Using a combination of xT scaling and direct interpolation at fixed pT, a reference transverse momentum spectrum at √s = 2:76TeV is constructed, which can be used for studying high-pT particle suppression in the dense QCD medium produced in heavy-ion collisions at that centre-of-mass energy. Copyright CERN.

One-dimensional Fermi accelerator model with moving wall described by a nonlinear van der Pol oscillator

A modification of the one-dimensional Fermi accelerator model is considered in this work. The dynamics of a classical particle of mass m, confined to bounce elastically between two rigid walls where one is described by a nonlinear van der Pol type oscillator while the other one is fixed, working as a reinjection mechanism of the particle for a next collision, is carefully made by the use of a two-dimensional nonlinear mapping. Two cases are considered: (i) the situation where the particle has mass negligible as compared to the mass of the moving wall and does not affect the motion of it; and (ii) the case where collisions of the particle do affect the movement of the moving wall. For case (i) the phase space is of mixed type leading us to observe a scaling of the average velocity as a function of the parameter (χ) controlling the nonlinearity of the moving wall. For large χ, a diffusion on the velocity is observed leading to the conclusion that Fermi acceleration is taking place. On the other hand, for case (ii), the motion of the moving wall is affected by collisions with the particle. However, due to the properties of the van der Pol oscillator, the moving wall relaxes again to a limit cycle. Such kind of motion absorbs part of the energy of the particle leading to a suppression of the unlimited energy gain as observed in case (i). The phase space shows a set of attractors of different periods whose basin of attraction has a complicated organization. © 2013 American Physical Society.

Soluções auto-similares das equações de Navier-Stokes em Lp-Fraco

Pós-graduação em Matemática - IBILCE

Desempenho de trator agrícola em duas profundidades de escarificação e dois teores de água no solo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação cardíaca de cães com degeneração valvar mixomatosa durante o emprego de enalapril, losartana, furosemida e suas combinações

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo dos planos amostrais e estimadores para a aplicação no dimensionamento da popoluação canina de Rio Claro - SP

Pós-graduação em Matemática Universitária - IGCE

Sequenciamento de linhas de montagem múltiplas em ambiente de produção enxuta utilizando simulação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

DE SITTER TRANSITIVITY, CONFORMAL TRANSFORMATIONS AND CONSERVATION LAWS

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo de cargas térmicas de uma aeronave e dimensionamento de um sistema de ar condicionado

This work deals with the thermal load study of a fictitious aircraft as well as scaling, in terms of the airflow and temperature of the air conditioning system, for heating and cooling of the its internal environment, aiming the thermal comfort of occupants. The first part is presented the techniques and methods utilized for modeling different heat exchanges that occur in the aircraft and then allowed to calculate the total heat load and the airflow and temperature necessary to comply with the requirements of the thermal comfort. Techniques to determine the basic parameters, as convection coefficient and global coefficient of heat exchange, are also presented. The work aims to develop a program, using a computational tool, to automate the calculations so that facilitate this study. It also allows to be used for other airplanes just changing parameters and the control variables related to the specific project. Finally the program performs calculations for a fictitious airplane, to analyze its functionality and the influence of parameters involved in the temperature controls. The program allowed analyzing the sensitivity of portions of the thermal load and the corresponding parameters of influence, as well as the scaling of the air conditioning in terms of airflow and temperature. It was considered, despite the simplifications, a good approximation to the actual values and then can be used in development of the other airplanes

Resolução do problema de sequenciamento de múltiplas linhas de montagem de modelos mistos em ambiente de produção enxuta

This work deals with the sequencing of Multi-Mixed-Model Assembly Lines in a lean manufacturing environment, where an operational structure where several kanbans support several mixed-model assembly lines, so that all assembly lines can receive parts or sub-assemblies from all suppliers. To optimize this system, the sequencing seeks to minimize the distance between the real consumption and the constant ideal consumption of parts or subassemblies, thereby reducing the scaling of kanbans and intermediate stocks. To solve the sequencing problems, the method Clustering Search was applied along with the metaheuristics Variable Neighborhood Search, Simulation Annealing and Iterative Local Search. Instances from the literature and generated instances were tested, thus allowing comparing the methods to each other and with other methods presented in the literature. The performance of the Clustering Search with Iterated Local Search stands out by the quality and robustness of their solutions, and mainly for its efficiency, whereas it converges to better results at a lower computational cost

Chaveamento de cargas intermitentes usando sensor de corrente

Due to concerns about rational use of energy, several alternative technologies of power generation appeared, including the conversion of solar energy into electrical energy by photovoltaic panels. In low-income households, the refrigerator represents considerable impact on the electric bill, since it requires constant power given its use in food preservation. It is possible to reduce this share, with the use of an alternative energy source. This work presents a timed switching electronic system, which allows commercial equipment that is not affected by short interruptions in the power supply to use a photovoltaic panel as a source of alternative energy, which usually do not provide energy continuously. Switching is made automatically in case of low incidence of sunlight, and without any form of energy storage. Between each switching, there is a dead time without power supply, therefore preventing the use of synchronizers circuits between the photovoltaic panel and the public power grid. A circuit containing a 80C31 microcontroller is used to control the system’s switching. The photovoltaic panel’s voltage inverter is in H bridge configuration, and is also controlled by the microcontroller through Pulse Width Modulation, which makes use of preprogrammed tables to generate the control signals of the power transistors. Through the use of software simulations, the proposed system was tested, which is capable of supplying intermittent single-phase loads. The simulations indicates that the project developed in this paper can be assembled into a prototype and be tested under real operating conditions, as long as the scaling of components, the characteristics of the photovoltaic panel to be used, and the project involved load are taken into account