Cours d'étude pour l'instruction du prince de Parme.... Directions pour la conscience d'un roi. T. 1 / par M. l'abbé de Condillac,... ; par François de Salignac de La Motte-Fénelon,...

Comprend : Directions pour la conscience d'un roi

Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the EuroSIDA Study.

OBJECTIVES: To investigate prevalence of transmitted drug-resistant human immunodeficiency virus (TDR) and factors associated with TDR and to compare virological and CD4 count response to combination antiretroviral therapy. METHODS: In this study, 525 mostly chronically infected EuroSIDA patients were included who had genotypic resistance tests performed on plasma samples collected while antiretroviral therapy naive. TDR was defined as at least one resistance mutation from a list proposed for genotypic TDR surveillance. Multivariable logistic regression was used to analyze factors associated with detection of TDR, with virological (viral load<500 copies/mL) and CD4 count response (>or=50% increase) to combination antiretroviral therapy at months 6-12. RESULTS: The overall prevalence of TDR was 11.4%, which was stable over 1996-2004. There were no significant differences in virological suppression (those resistant to at least one drug prescribed versus susceptible), adjusted odds ratio: 0.68 (95% confidence interval: 0.27 to 1.71; P=0.408) or CD4 count response, adjusted odds ratio: 1.65 (95% confidence interval: 0.73 to 3.73; P=0.231). CONCLUSIONS: Prevalence of TDR in antiretroviral-naive patients was found to be in line with other European studies. No significant differences were found in virological and CD4 count response after initiation of first-line combination antiretroviral therapy between resistant and susceptible patients, possibly due to the small number of patients with resistance and consequently low power.

Vie de saint François de Sales : évêque et prince de Genève, 1567-1622 / par F. Valentin

Collection : Les petits livres de M. le curé

Articles convenus entre le Roi et le prince-évêque, l'église et l'état de Liège, pour l'exécution du traité du 24 mai 1772 et en conformité de l'article séparé relatif à l'art 1er dudit traité. [Ratification du 11 décembre.]

[Acte royal. 1773-12-11. Versailles]

Recueil de pièces relatives au prieuré de Dhuisy, diocèse de Meaux, formé par Charles de Chantecler, prieur et seigneur de Dhnisy, pour les besoins de son procès contre Henri de Bourbon, prince de Condé, en 1573.

L'acte de fondation de ce prieuré (fol. 17) porte la date de 1170. — Ce ms. a appartenu à « l'abbé de Sencour, chanoine de Rouen. »

« Ordonnance du hancquot, que fist en la ville de Lisie très haut et très poissant prince Phelippe, par la grace de Dieu, duc de Bourgoigne et de Brabant, etc., l'an mil quatre cens chinquante trois, le XVIIe jour de febvrier. » (Voeux du Faisan).

Contient : « Registre des veux qui furent fais en intencion d'aler sur les Turs, l'an mil quatre cens. chinquante trois, en la presence de très noble et tres redouté prince Phelippe, par la grace de Dieu, duc de Bourgoigne... » ; « Coppie de la bulle donnée l'an lXIII (1463) par le pape Pius [II], et translatée, ce dit an, par solennel orateur l'evesque de Tournay, » G. Filastre ; « Epistre faitte en la contemplacion du saint voyage de Turquie, adreissant à la très crestienne et très heureuse maison de Bourgogne »

Comparison of C-reactive protein and white blood cell count with differential in neonates at risk for septicaemia.

We prospectively compared the diagnostic value of C-reactive protein (CRP) and white blood cell counts for detection of neonatal septicaemia. Sensitivity and specifity in receiver operating characteristics, and positive and negative predictive value of CRP and white blood cell count were compared in 195 critically ill preterm and term newborns clinically suspected of infection. Blood cultures were positive in 33 cases. During the first 3 days after birth CRP elevation (sensitivity 75%, specifity 86%), leukopenia (67%/90%), neutropenia (78%/80%) and immature to total neutrophil count (I/T) ratio (78%/73%) were good diagnostic parameters, as opposed to band forms with absolute count (84%/66%) or percentage (79%/71%), thrombocytopenia (65%/57%) and toxic granulations (44%/94%). Beyond 3 days of age elevated CRP (88%/87%) was the best parameter. Increased total (84%/66%) or percentage band count (79%/71%) were also useful. Leukocytosis (74%/56%), increased neutrophils (67%/65%), I/T ratio (79%/47%), thrombocytopenia (65%/57%) and toxic granulations had a low specifity. The positive predictive value of CRP was 32% before and 37% after 3 days of age, that of leukopenia was 37% in the first 3 days. CONCLUSION: During the first 3 days of life CRP, leukopenia and neutropenia were comparably good tests while after 3 days of life CRP was the best single test in early detection of neonatal septicaemia. Serial CRP estimations confirm the diagnosis, monitor the course of infection and the efficacy of antibiotic treatment.