886 resultados para Rancho Santa Ana Botanic Garden of the Native Plants of California.
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Ink on linen; location, type of plantings; bird pool, tennis court, steps, footpath; notes; signed. 43 x 23 cm. Scale: 1" = 20' [from photographic copy by Lance Burgharrdt]
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Spine title: Loudon, Ornamental Annuals.
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Portions of this work originally appeared in the "New monthly magazine". cf.Introd.
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Includes index.
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Thesis (doctoral)--Universitat Greifswald.
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Mode of access: Internet.
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"Honolulu, HI, April 16, 1984; Captain Cook, HI, April 17, 1984; Wailuki, HI, April 18, 1984; Lihue, HI, April 20, 1984"--Pt. 1. -- "Appendix"--Pt. 2.
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At head of title: Royal botanic gardens, Kew.
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Mode of access: Internet.
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Spine title: Plants & vertebrates of Hanover, N.H.
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Mode of access: Internet.
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Pyrrhacoricin is a naturally occurring antimicrobial peptide from the European fire bug Pyrrhocoris apterus. It has submicromolar activity against a range of Gram-negative bacterial strains and has created recent interest as a lead for the development of novel antibiotic compounds. In this study, we have used NMR spectroscopy to determine the solution structures of pyrrhocoricin and a synthetic macrocyclic derivative that has improved in vivo pharmaceutical properties. Native pyrrhocoricin is largely disordered in solution, but there is evidence of a subpopulation with ordered turn regions over residues 2-5, 4-7, and 16-19. The macrocyclic derivative incorporates a nine amino acid linker joining the N- and C-termini, which does not adversely affect the antimicrobial potency but leads to a broader spectrum of activity. The NMR data suggest that the turn conformations in the cyclic derivative are similar to those in the native form, thus implicating them in the biological function. (C) 2004 Wiley Periodicals, Inc.