The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.

Vertebrate odd-skipped related genes (Osr) have an essential function during the formation of the intermediate mesoderm (IM) and the kidney structures derived from it. Here, we show that these genes are also crucial for limb bud formation in the adjacent lateral plate mesoderm (LPM). Reduction of zebrafish Osr function impairs fin development by the failure of tbx5a maintenance in the developing pectoral fin bud. Osr morphant embryos show reduced wnt2b expression, and increasing Wnt signaling in Osr morphant embryos partially rescues tbx5a expression. Thus, Osr genes control limb bud development in a non-cell-autonomous manner, probably through the activation of Wnt2b. Finally, we demonstrate that Osr genes are downstream targets of retinoic acid (RA) signaling. Therefore, Osr genes act as a relay within the genetic cascade of fin bud formation: by controlling the expression of the signaling molecule Wnt2ba in the IM they play an essential function transmitting the RA signaling originated in the somites to the LPM.

Chroniques de Espa[n]ya fins aci no diuulgades : que tracta d[e]ls Nobles e Inuictissims Reys dels Gots, y gestes de aquells, y dels Co[n]tes de Barcelona, e Reys de Arago, ab moltes coses dignes de perpetua memoria / compilada per lo honorable y discret

Nouament imprimida en lany M.D.xlvij.

Reportori general y breu sumari per orde alphabetich de totes les materies dels Furs de Valencia, fins les Corts del any 1604 inclusiue y dels priuilegis de dita ciutat y regne ab vna taula al principi ...

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Chroniques de Espanya [Texto impreso] : fins aci no divulgades : que tracta dels nobles e invictissims Reys dels Gots y gestes de aquells y dels Contes de Barcelona e Reys de Arago...

Copia digital: Biblioteca Valenciana, 2011

Expropriação dos bens utilizados para fins de tráfico ilícito de entorpecentes / Edilson Pereira Nobre Júnior.

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Abuso do poder político e manipulação da máquina administrativa com fins eleitorais / Ricardo Rodrigues. --

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Desapropriação para fins de reforma urbana

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