972 resultados para Oda III 30


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komponiert von A. Haidmann. [Gedicht] von Hugo Zuckermann

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Vorbesitzer: Dominikanerkloster Frankfurt am Main; Bartholomaeusstift Frankfurt am Main;

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Boberach: Die Wahlmänner werden über drei Reden unterrichtet, die ihr Abgeordneter in der Nationalversammlung nicht halten konnte: Über die der Kommission zur Untersuchung der Zustände des Großherzogtums Posen zu erteilenden Befugnisse. - Über die Abschaffung der Todesstrafe. - Über den Antrag des Abgeordneten Stein auf Erlaß eines Armeebefehls gegen die reaktionären Bestrebungen in der Armee

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Welsch (Projektbearbeiter): Alphabetisches Verzeichnis von insgesamt 558 Abgeordneten der Frankfurter Nationalversammlung samt Angabe von Beruf, Herkunftsland, Wahlbezirk und Frankfurter Wohnsitz; zusätzliche Auflistung nach Ländern. Im Anhang Zusammenstellung der ausgetretenen Mitglieder (Stand 5. Februar 1849)

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BACKGROUND Chemotherapy plus bevacizumab is a standard option for first-line treatment in metastatic colorectal cancer (mCRC) patients. We assessed whether no continuation is non-inferior to continuation of bevacizumab after completing first-line chemotherapy. PATIENTS AND METHODS In an open-label, phase III multicentre trial, patients with mCRC without disease progression after 4-6 months of standard first-line chemotherapy plus bevacizumab were randomly assigned to continuing bevacizumab at a standard dose or no treatment. CT scans were done every 6 weeks until disease progression. The primary end point was time to progression (TTP). A non-inferiority limit for hazard ratio (HR) of 0.727 was chosen to detect a difference in TTP of 6 weeks or less, with a one-sided significance level of 10% and a statistical power of 85%. RESULTS The intention-to-treat population comprised 262 patients: median follow-up was 36.7 months. The median TTP was 4.1 [95% confidence interval (CI) 3.1-5.4] months for bevacizumab continuation versus 2.9 (95% CI 2.8-3.8) months for no continuation; HR 0.74 (95% CI 0.58-0.96). Non-inferiority could not be demonstrated. The median overall survival was 25.4 months for bevacizumab continuation versus 23.8 months (HR 0.83; 95% CI 0.63-1.1; P = 0.2) for no continuation. Severe adverse events were uncommon in the bevacizumab continuation arm. Costs for bevacizumab continuation were estimated to be ∼30,000 USD per patient. CONCLUSIONS Non-inferiority could not be demonstrated for treatment holidays versus continuing bevacizumab monotheray, after 4-6 months of standard first-line chemotherapy plus bevacizumab. Based on no impact on overall survival and increased treatment costs, bevacizumab as a single agent is of no meaningful therapeutic value. More efficient treatment approaches are needed to maintain control of stabilized disease following induction therapy. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov, number NCT00544700.

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Previous restriction analysis of cloned equine DNA and genomic DNA of equine peripheral blood mononuclear cells had indicated the existence of one c epsilon, one c alpha and up to six c gamma genes in the haploid equine genome. The c epsilon and c alpha genes have been aligned on a 30 kb DNA fragment in the order 5' c epsilon-c alpha 3'. Here we describe the alignment of the equine c mu and c gamma genes by deletion analysis of one IgM, four IgG and two equine light chain expressing heterohybridomas. This analysis establishes the existence of six c gamma genes per haploid genome. The genomic alignment of the cH-genes is 5' c mu/(/) c gamma 1/(/) c gamma 2/(/) c gamma 3/(/) c gamma 4/(/) c gamma 5/(/) c gamma 6/(/) c epsilon-c alpha 3', naming the c gamma genes according to their position relative to c mu. For three of the c gamma genes the corresponding IgG isotypes could be identified as IgGa for c gamma 1, IgG(T) for c gamma 3 and IgGb for c gamma 4.

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Post Postremam Navgerianam et Victorianam correctionem Emendata à Ioanne Sturmio. Cum Indice locupletissimo. Additae etiam sunt Erasmi Roterodami, et Philippi Melanchthonis, et Bartholomaei Latomi annotationes in eosdem libros. Omnia, quàm antehac, et locupletiora et emendatiora.

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Vorbesitzer: Dominikanerkloster Frankfurt am Main