CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

Inheritance of each chromosome depends upon its centromere. A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location. We find that CENP-A is quantitatively retained at the centromere upon which it is initially assembled. CENP-C binds to CENP-A nucleosomes and is a prime candidate to stabilize centromeric chromatin. Using purified components, we find that CENP-C reshapes the octameric histone core of CENP-A nucleosomes, rigidifies both surface and internal nucleosome structure, and modulates terminal DNA to match the loose wrap that is found on native CENP-A nucleosomes at functional human centromeres. Thus, CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.

Methods of visualization and analysis of cardiac depolarization in the three dimensional space

The master thesis presents methods for intellectual analysis and visualization 3D EKG in order to increase the efficiency of ECG analysis by extracting additional data. Visualization is presented as part of the signal analysis tasks considered imaging techniques and their mathematical description. Have been developed algorithms for calculating and visualizing the signal attributes are described using mathematical methods and tools for mining signal. The model of patterns searching for comparison purposes of accuracy of methods was constructed, problems of a clustering and classification of data are solved, the program of visualization of data is also developed. This approach gives the largest accuracy in a task of the intellectual analysis that is confirmed in this work. Considered visualization and analysis techniques are also applicable to the multi-dimensional signals of a different kind.

Methods of Visualization and Analysis of Cardiac Depolarization in the Three Dimensional Space

Research analysis of electrocardiograms (ECG) today is carried out mostly using time depending signals of different leads shown in the graphs. Definition of ECG parameters is performed by qualified personnel, and requiring particular skills. To support decoding the cardiac depolarization phase of ECG there are methods to analyze space-time convolution charts in three dimensions where the heartbeat is described by the trajectory of its electrical vector. Based on this, it can be assumed that all available options of the classical ECG analysis of this time segment can be obtained using this technique. Investigated ECG visualization techniques in three dimensions combined with quantitative methods giving additional features of cardiac depolarization and allow a better exploitation of the information content of the given ECG signals.

Variable stars,

"Corrections to index": slip laid in.

Sixième symphonie en Do mineur : pour grand orchestre : op. 58 /

Mode of access: Internet.

Die Toteninsel = [music] : The island of the dead : symphonic poem based on Böcklin's famous picture for orchestra, Op. 29 /

Mode of access: Internet.

Russian album. [music] : selected compositions for the pianoforte.

Gavotte pastorale / A. Arensky -- Golden wedding minuet / G. Karganoff -- Arabesque / G. Karganoff -- Berceuse / Alex Ilynsky -- Fantastic tale / H. Pachulski -- Slumber song / L. Arkadieff -- Album leaf, in C / Alexander Kopylow -- Romance in A[flat] / Nikolas Rimsky-Korsakoff -- Arabesque / B. Wrangell -- Canzonetta / Caesar Cui -- Nocturne / Ignace Krzyzanowski -- Berceuse / G. Karganoff -- Prelude / A. Kopylow -- The Cuckoo / A. Arensky -- Elegie / Sergei Yóuferoff -- Valse capricieuse / Boleslaus Grodzki -- Intermezzo / G. Karganoff -- Berceuse / S. Barmotine -- The Music box / Anatole Liadow -- Novellette / N. Rimsky-Korsakow -- Tarentelle / Gʹenari Karganoff -- By the sea / A. Arensky.

Concerto pour le piano avec accompagnemento d'orchestre. [music] /

Original version. Not to be confused with the revised version played for the first time by the composer in Carnegie Hall, N.Y., Jan. 28, 1919.

Sonate H-Dur, Klavier solo, op. 9 = Sonata in B major, piano solo /

Mode of access: Internet.

Suite no. 2, op. 17, 2 pianos /

Introduction -- Valse -- Romance -- Tarantelle.

Kolokola = Les cloches = Die Glocken = The bells : for orchestra, chorus and solo : op. 35 /

Russian, German and English words.

Mesures micrométriques d'étoiles doubles, faites à St.-Pétersbourg et à Domkino. (3. sér. des mesures d'étoiles doubles)

Mode of access: Internet.

Istoricheskīĭ vi︠e︡stnik; istoriko-literaturnyĭ zhurnal.

"Includes the section "Kritika i biblīografī︠ia︡."