Tractatus de Judaeis eorum privilegiis, observantia, et recto intellectu ... : cum summariis, & indice ...

auctore Joseph Sessa

Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data.

Aims: To evaluate the implications of an Absorb bioresorbable vascular scaffold (Absorb BVS) on the morphology of the superficial plaques. Methods and results: Forty-six patients who underwent Absorb BVS implantation and 20 patients implanted with bare metal stents (BMS) who had serial optical coherence tomographic examination at baseline and follow-up were included in this analysis. The thin-capped fibroatheromas (TCFA) were identified in the device implantation regions and in the adjacent native coronary segments. Within all regions, circumferential locations of TCFA and calcific tissues were identified, and the neointimal thickness was measured at follow-up. At six to 12-month follow-up, only 8% of the TCFA detected at baseline were still present in the Absorb BVS and 27% in the BMS implantation segment (p=0.231). Sixty percent of the TCFA in native segments did not change their phenotype at follow-up. At short-term follow-up, significant reduction in the lumen area of the BMS was noted, which was higher compared to that reported in the Absorb BVS group (-2.11±1.97 mm2 vs. -1.34±0.99 mm2, p=0.026). In Absorb BVS, neointima tissue continued to develop at midterm follow-up (2.17±0.48 mm2 vs. 1.38±0.52 mm2, p<0.0001) and covered the underlying tissues without compromising the luminal dimensions (5.93±1.49 mm2 vs. 6.14±1.49 mm2, p=0.571) as it was accommodated by the expanded scaffold (8.28±1.74 mm2 vs. 7.67±1.28 mm2, p<0.0001). Conclusions: Neointimal tissue develops following either Absorb BVS or BMS implantation and shields lipid tissues. The neointimal response in the BMS causes a higher reduction of luminal dimensions compared to the Absorb BVS. Thus, Absorb BVS may have a value in the invasive re-capping of high-risk plaques.

Chrestomathia Talmudica et Rabbinica : Collegit brevi annotatione illustravit indice verborum

auxit Geo. Benedict. Winer

Chrestomathia e paraphrasibus Chaldaicis et Talmude : delecta noris brevibus et indice verborum difficiliorum illustrata

ed. Georgius Laurentius Bauer

Impact of local endothelial shear stress on neointima and plaque following stent implantation in patients with ST-elevation myocardial infarction: A subgroup-analysis of the COMFORTABLE AMI-IBIS 4 trial.

BACKGROUND Numerous studies have demonstrated an association between endothelial shear stress (ESS) and neointimal formation after stent implantation. However, the role of ESS on the composition of neointima and underlying plaque remains unclear. METHODS Patients recruited in the Comfortable AMI-IBIS 4 study implanted with bare metal stents (BMS) or biolimus eluting stents (BES) that had biplane coronary angiography at 13month follow-up were included in the analysis. The intravascular ultrasound virtual-histology (IVUS-VH) and the angiographic data were used to reconstruct the luminal surface, and the stent in the stented segments. Blood flow simulation was performed in the stent surface, which was assumed to represent the luminal surface at baseline, to assess the association between ESS and neointima thickness. The predominant ESS was estimated in 3-mm segments and was correlated with the amount of neointima, neointimal tissue composition, and with the changes in the underlying plaque burden and composition. RESULTS Forty three patients (18 implanted with BMS and 25 with BES) were studied. In both stent groups negative correlations were noted between ESS and neointima thickness in BMS (P<0.001) and BES (P=0.002). In BMS there was a negative correlation between predominant ESS and the percentage of the neointimal necrotic core component (P=0.015). In BES group, the limited neointima formation did not allow evaluation of the effect of ESS on its tissue characteristics. ESS did not affect vessel wall remodeling and the plaque burden and composition behind BMS (P>0.10) and BES (P>0.45). CONCLUSIONS ESS determines neointimal formation in both BMS and BES and affects the composition of the neointima in BMS. Conversely, ESS does not impact the plaque behind struts irrespective of stent type throughout 13months of follow-up.

Efficacy of patient-administered mechanical and/or chemical plaque control protocols in the management of peri-implant mucositis. A systematic review

AIM To systematically assess the efficacy of patient-administered mechanical and/or chemical plaque control protocols in the management of peri-implant mucositis (PM). MATERIAL AND METHODS Randomized (RCTs) and Controlled Clinical Trials (CCTs) were identified through an electronic search of three databases complemented by manual search. Identification, screening, eligibility and inclusion of studies was performed independently by two reviewers. Studies without professional intervention or with only mechanical debridement professionally administered were included. Quality assessment was performed by means of the Cochrane Collaboration's tool for assessing risk of bias. RESULTS Eleven RCTs with a follow-up from 3 to 24 months were included. Definition of PM was lacking or heterogeneously reported. Complete resolution of PM was not achieved in any study. One study reported 38% of patients with complete resolution of PM. Surrogate end-point outcomes of PM therapy were often reported. The choice of control interventions showed great variability. The efficacy of powered toothbrushes, a triclosan-containing toothpaste and adjunctive antiseptics remains to be established. High quality of methods and reporting was found in four studies. CONCLUSIONS Professionally- and patient-administered mechanical plaque control alone should be considered the standard of care in the management of PM. Therapy of PM is a prerequisite for the prevention of peri-implantitis.

Changes of coronary plaque composition correlate with C-reactive protein levels in patients with ST-elevation myocardial infarction following high-intensity statin therapy.

OBJECTIVES Levels of inflammatory biomarkers associate with changes of coronary atheroma burden in statin-treated patients with stable coronary artery disease. This study sought to determine changes of plaque composition in vivo in relation to high-sensitivity C-reactive protein (hs-CRP) levels in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin therapy. METHODS The IBIS-4 study performed serial (baseline and 13-month), 2-vessel intravascular ultrasound (IVUS) and radiofrequency-IVUS of the non-infarct-related arteries in patients with STEMI treated with high-intensity statin therapy. The present analysis included 44 patients (80 arteries) with serial measurements of hs-CRP. RESULTS At follow-up, median low-density lipoprotein cholesterol (LDL-C) levels decreased from 126 to 77 mg/dl, HDL-C increased from 44 to 47 mg/dl, and hs-CRP decreased from 1.6 to 0.7 mg/L. Regression of percent atheroma volume (-0.99%, 95% CI -1.84 to -0.14, p = 0.024) was accompanied by reduction of percent fibro-fatty (p = 0.04) and fibrous tissue (p < 0.001), and increase in percent necrotic core (p = 0.006) and dense calcium (p < 0.001). Follow-up levels of hs-CRP, but not LDL-C, correlated with changes in percent necrotic core (p = 0.001) and inversely with percent fibrous tissue volume (p = 0.008). Similarly, baseline-to-follow-up change of hs-CRP correlated with the change in percent necrotic core volume (p = 0.02). CONCLUSIONS In STEMI patients receiving high-intensity statin therapy, stabilization of VH-IVUS-defined necrotic core was confined to patients with lowest on-treatment levels and greatest reduction of hs-CRP. Elevated CRP levels at follow-up may identify progression of high-risk coronary plaque composition despite intensive statin therapy and overall regression of atheroma volume.

Diomedis Grammatici Opvs, Ab Ioanne Caesario, ita emendatum, scholijsq[ue] illustratum, ut nulla porrò labes insideat. Item Donati De Octo Orationis partibus, & barbarismo libellus, ab eodem recognitus. Cum Indice

Fingerprint nach Ex. der HAAB Weimar und der UB Frankfurt

Indice alfabetico dei rabbini e scrittori israeliti di cose giudaiche in Italia : con richiami bibliografici e note illustative

Marco Mortara

Wais III. Indice de comprensión verbal : Descripción de una muestra para las edades 25-34 años en la ciudad de La Plata, según género

En el marco de la segunda etapa del Proyecto de Investigación para la Construcción de Normas para los subtests que conforman el índice de Comprensión Verbal (ICV) de la Escala de Inteligencia para Adultos de Wechsler-WAIS III, para la ciudad de La Plata, se analizan los resultados observados sobre una muestra probabilística de 381 sujetos, entre 25-34 años, de nivel terciario y universitario, según el género. En el subtest de Información el mejor desempeño se observó en los varones de ambos grupos de edad. En el subtest de Analogías, el mejor desempeño se observó en las mujeres del grupo de edad 25-29 años, seguido por el de los varones del grupo de edad 30-34 años.Las mujeres del grupo de edad 25-29 años mostraron el mejor desempeño en comprensión verbal. Sólo para este caso; el ICV calculado se ubicó levemente por encima del promedio estandarizado. Las mujeres del grupo de edad 30- 34 años, y los varones, en ambos grupos de edad, mostraron un ICV calculado levemente por debajo del promedio estandarizado. Las diferencias entre el puntaje promedio obtenido en cada uno de los subtests para ambos géneros en los dos grupos de edad, y el promedio esperado, no son estadísticamente significativos (p es menor que 0,05). La misma interpretación corresponde realizar para el ICV. El ICV calculado en las mujeres del grupo de edad 25-29 años, las ubica en el percentil 53 indicando que su desempeño específico observado en comprensión verbal, deja por debajo al 53de los sujetos de su grupo de referencia. Los rendimientos observados que dependen de los conocimientos adquiridos en la escuela y a través de la experiencia cultural, son de levemente superiores al promedio. Su capacidad para hacer uso del cuerpo de conocimiento general acumulado, para emitir juicios y resolver problemas tales como tareas de abstracción de las relaciones entre dos elementos distintos, o la de formar conceptos, son normales y alcanzan a superar el promedio del rendimiento de los sujetos tipificados para los mismos rangos de edad. El ICV calculado en las mujeres del grupo de edad 30-34 años, y en los varones de ambos grupos, ubica a los sujetos en el percentil 45 indicando que su desempeño específico observado en comprensión verbal, deja por debajo al 45de los sujetos de su grupo de referencia. Los rendimientos observados son normales aunque no llegan a superar el promedio del rendimiento de los sujetos tipificados para los mismos rangos de edad. El promedio de puntajes en cada uno de tres subtest que integran el ICV, así como el promedio en el ICV para ambos géneros, ubica a los sujetos dentro promedio esperado, según su grupos de edad (Paidós, 2002). Siguiendo los criterios establecidos en el Manual de la Prueba para la interpretación de las diferencias encontradas entre los puntajes e índices observados sobre una muestra de mujeres y varones instruidos, y los estandarizados, este Equipo considera que debería analizarse una muestra más amplia para determinar si dicha diferencia es inusual o resulta común en la población en general (Wechsler, 2002)