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La tesis doctoral que se presenta realiza un análisis de la evolución del paisaje fluvial de las riberas de los ríos Tajo y Jarama en el entorno de Aranjuez desde una perspectiva múltiple. Contempla y conjuga aspectos naturales, tales como los hidrológicos, geomorfológicos y ecológicos; también culturales, como la regulación hidrológica y la gestión del agua, las intervenciones en cauce y márgenes, la evolución de la propiedad y los cambios de usos del suelo, fundamentalmente. Este análisis ha permitido identificar el sistema de factores, dinámico y complejo, que ha creado este paisaje, así como las interrelaciones, conexiones, condicionantes y dependencias de los descriptores paisajísticos considerados. Por ejemplo, se han estudiado las relaciones cruzadas observadas entre dinámica fluvial-propiedad de la tierra-estado de conservación, cuestiones que hasta la fecha no habían sido tratadas, evaluadas o cuantificadas en otros trabajos dedicados a esta zona. La investigación se ha organizado en tres fases fundamentales que han dado lugar a los capítulos centrales del documento (capítulos 2, 3 y 4). En primer lugar, se ha realizado una caracterización de los factores, naturales y culturales, que organizan el paisaje de este territorio eminentemente fluvial (geomorfología, factores climáticos e hidrológicos, vegetación, propiedad de la tierra y elementos culturales de significación paisajística). A continuación, se ha realizado el estudio de la evolución del paisaje fluvial mediante el análisis de diversos elementos, previamente identificados y caracterizados. Para ello se han procesado imágenes aéreas correspondientes a cinco series temporales así como varios planos antiguos, obteniendo una amplia base de datos que se ha analizado estadísticamente. Finalmente, se han contrastado los resultados parciales obtenidos en los capítulos anteriores, lo que ha permitido identificar relaciones causales entre los factores que organizan el paisaje y la evolución de los elementos que lo constituyen. También, interconexiones entre factores o entre elementos. Este método de trabajo ha resultado muy útil para la comprensión del funcionamiento y evolución de un sistema complejo, como el paisaje de la vega de Aranjuez, un territorio con profundas y antiguas intervenciones culturales donde lo natural, en cualquier caso, siempre subyace. Es posible que la principal aportación de este trabajo, también su diferencia más destacada respecto a otros estudios de paisaje, haya sido mostrar una visión completa y exhaustiva de todos los factores que han intervenido en la conformación y evolución del paisaje fluvial, destacando las relaciones que se establecen entre ellos. Esta manera de proceder puede tener una interesante faceta aplicada, de tal manera que resulta un instrumento muy útil para el diseño de planes de gestión de este territorio fluvial. No en vano, una parte sustancial de la vega del Tajo-Jarama en Aranjuez es un Lugar de Importancia Comunitaria (LIC) y su posterior e ineludible declaración como Zona de Especial Conservación (ZEC) de la Red Natura 2000, de acuerdo con lo establecido en la Directiva 92/43/CE, exige la elaboración de un Plan de Gestión que, en gran medida, podría nutrirse de lo presentado, analizado e interpretado en este trabajo. En este sentido, conviene señalar la conciencia ya asumida de considerar, por su carácter integrador de la realidad territorial, el paisaje como elemento clave para la gestión adecuada de la naturaleza y el territorio. Por otra parte, se considera que los resultados de esta Tesis Doctoral permitirían plantear medidas para la puesta en valor de un paisaje sobresaliente, cuyos límites sobrepasan con creces los que en la actualidad conforman el Paisaje Cultural declarado por la UNESCO. En suma, el análisis de este espacio fluvial realizado con la profundidad y amplitud que permite el método de trabajo seguido puede utilizarse para el diseño de estrategias que dirijan la evolución de este territorio en una línea que garantice su conservación global en términos paisajísticos, patrimoniales y ecológicos, permitiendo además, de este modo, su uso equilibrado como recurso económico, cultural o educativo. This doctoral thesis shows an analysis of fluvial landscape evolution from multiple perspectives on the banks of Tagus and Jarama rivers, around Aranjuez. The thesis contemplates and combines natural features, such as hydrological, geomorphological and ecological features, as well as cultural features, like hydrological regulation and water management, interventions in channels and margins, changes in ownership and land use changes, mainly. This analysis has allowed to identify the factors system, dynamic and complex, that this landscape has created, as well as the interrelationships, connections, constraints and dependencies among considered landscape descriptors. For example, we have studied the relationships observed among fluvial dynamics- land ownership -conservation status, issues not addressed, assessed or quantified up to now in other works about this area. The research is organized into three major phases that led to the paper's central chapters (Chapters 2, 3 and 4). First, there has been a characterization of the factors, both natural and cultural, that organize the landscape of this predominantly fluvial area (geomorphology, climate and hydrological factors, vegetation, land and cultural elements of landscape significance). Then, it was made to study of fluvial landscape evolution by analyzing various elements previously identified and characterized. Aerial images were processed for five series and several old maps, obtaining an extensive database, that has been analyzed statistically. Finally, we have contrasted the partial results obtained in the previous chapters, making it possible to identify causal relationships between the factors that organize the landscape and the evolution of the elements that constitute it. This working method has been very useful for understanding the operation and evolution of a complex system, as the landscape of the Vega de Aranjuez, a territory with deep and ancient cultural interventions where anyway, nature feature always lies. It is possible that the main contribution of this work, also its most prominent difference compared with other studies of landscape, has been to show a complete and exhaustive view of all factors involved in the formation and evolution of the fluvial landscape, highlighting the relationships established among them. This approach could have an interesting applied facet, so that is a very useful tool for designing management plans on this river territory. Not surprisingly, a substantial part of the valley of the Tagus-Jarama in Aranjuez is a Site of Community Importance (SCI) and their subsequent and inevitable declaration as Special Area of Conservation (SAC) of the Natura 2000 network, in accordance with the provisions Directive 92/43/EC, requires the development of a management plan that largely could draw on what was presented, analyzed and interpreted in this paper. In this regard, it should be noted conscience and assumed to consider, on the inclusiveness of territorial reality, the landscape as a key element for the proper management of nature and territory. On the other hand, it is considered that the results of this thesis allow to propose measures for enhancement of outstanding scenery, which go well beyond the boundaries that currently the Cultural Landscape declared by UNESCO. In sum, the analysis of this river area made with the depth and breadth that enables working method can be used to design strategies that address the evolution of this territory in a line that guarantees global conservation landscape terms, heritage and ecological, also, allowing its use as a balancing economic, cultural or educational resource.

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Para acercarnos al pensamiento creativo de Fernando Higueras como arquitecto, partimos del estudio de sus constantes creativas en evolución cronológica divididas en 9 direcciones de investigación. En ellas observamos la importancia de su obra NO CONSTRUIDA, como germen de las constantes creativas de su pensamiento y parte de ella la estudiamos, analizamos y reconstruimos gráficamente en 3D. Fernando Higueras aprendía de sus obras o propuestas arquitectónicas anteriores llegando a la madurez constructiva y formal colmada de Belleza a través de la composición y combinación de dichas constantes con pasmosa naturalidad. Además es importante añadir, para llegar a la comprensión de las constantes del pensamiento creativo del arquitecto, el componente de “intuición” de todo artista, de su modo de mirar y observar las cosas como fuente de inspiración. El “modo de mirar” del arquitecto nos habla de su sensibilidad al hábitat popular y vernáculo del hombre. Gracias a Antonio Miró en el período 1963-1970, Fernando Higueras pudo dar marco real a gran parte de sus ideas constructivas. El objeto de estudio del presente trabajo es llegar a las “invariantes” del arquitecto para comprender su pensamiento creativo. Los objetivos del presente estudio han sido conocer mejor su pensamiento, su obra desde un punto de vista cronológico-evolutivo para poder llegar a entender las relaciones y conexiones creativas entre unas y otras, observar y constatar la evolución de sus constantes creativas y compositivas, de analizar gráficamente parte de su obra no construida para llegar a la mejor comprensión de dichas constantes reconstruyéndolas con los medios gráficos digitales actuales. La reconstrucción en 3D de parte de su obra no construida constata la magnitud de su pensamiento creativo. La metodología empleada parte de la recopilación de toda la información necesaria, escritos, artículos en revistas o periódicos, críticas, observaciones, planos, proyectos, memorias, fotografías de la época, maquetas, opiniones de sus contemporáneos, familiares o amigos y visita de parte de su obra construida. A partir de ahí se fijan 9 direcciones de investigación para cada constante de su pensamiento creativo. En cada dirección se analiza desde dos puntos de vista diferentes. Un primer punto de vista teórico o cronológico-evolutivo a partir de la selección de algunas de sus obras construidas y no construidas. Y otro segundo punto de vista gráfico basándose en el estudio y reconstrucción de parte de su obra no construida. En resultado, se ha estudiado la evolución de su obra viendo las conexiones y relaciones entre unas y otras llegando a la madurez de sus constantes creativas en sus obras, algunas construidas y otras no construidas. Fernando Higueras se perfecciona así mismo, intentando hacer las cosas cada vez un poco mejor, llegando a dominar sus propias constantes en total madurez y expresión formal y constructiva. La elaboración de modelos tridimensionales en 13 proyectos de su obra no construida nos refresca la capacidad de su pensamiento creativo, además de analizar en parte de ellas los gérmenes constructivos y compositivos de muchas de sus ideas o constantes creativas. Finalmente, este trabajo ha contribuido a llegar a entender a Fernando Higueras en una dimensión más amplia, desde el frescor de su obra no construida hasta la capacidad de su pensamiento creativo, de la evolución de sus constantes, del estudio de sus últimos proyectos no construidos, de su sensibilidad a todas las artes y a todo lo que engloba Belleza. Las 360 láminas de dibujos que se aportan inician el estudio y análisis de su vasta obra no construida. ABSTRACT The analysis of Fernando Higueras's creative thought as an architect begins with a study of his main creative themes and their chronological evolution, divided into nine directions of research. Here we see the importance of his UNBUILT work as the germ of the creative themes of his thought, part of which we study, analyse and reconstruct graphically in 3-D. Fernando Higueras drew on his earlier architectural works and ideas and reached an ultimate constructive and formal maturity that was infused with beauty through composition and the amazingly natural combination of these keynote themes. In order to gain a greater understanding of the key themes of the architect's creative thought it is also worth noting the element of artists' intuition, their way of seeing and observing the world as a source of inspiration. The architect's "way of seeing" reveals his sensitivity to the popular and traditional human habitat. Thanks to Antonio Miró, in the period between 1963 and 1970 Fernando Higueras was able to provide a real framework for a large part of his constructive ideas. The object of study of the present work is to determine the architect's “invariables” as a means of understanding his creative thought. The aims of the present study are to explore his thoughts in greater depth, to examine his work from the chronological-evolutionary point of view for an insight into the relationships and the creative connections between them, to observe and apprehend the evolution of his main creative themes and compositional keynotes, to analyse graphically part of his unbuilt work in order to improve our understanding of these underlying themes through their reconstruction using the latest graphic digital resources. The 3-D reconstruction of part of his unbuilt work highlights the magnitude of his creative thought. The methodology used to collect all the necessary information includes an examination of his writings and articles in journals and newspapers, criticisms, observations, plans, projects, building specifications, period photographs, models, the opinions of his contemporaries, family and friends, and visits to some of his built work. Nine directions of research were then established for each main theme of his creative thought. Each direction includes an analysis from two different points of view: the first, theoretical or chronological-evolutionary aspect, based on a selection of some of his built and unbuilt works; and a second graphic aspect based on the study and reconstruction of part of his unbuilt work. The result is a survey of the evolution of his work with a view to establishing the connections and their interrelationships, through to the ultimate maturity of his creative themes in both his built and unbuilt work. Fernando Higueras is on a constant quest for excellence, a perpetual desire to do things a little better, until a point where he gains mastery over his own recurrent themes, in the fullness of maturity and of his formal and constructive expression. The creation of three-dimensional models in 13 projects of his unbuilt work offers a new look at the capacity of his creative thought, in addition to the analysis of the evidence in some of these projects of the constructive and compositional germs of many of his ideas and themes. Finally, this work has contributed to the understanding of Fernando Higueras in a broader dimension, from the freshness of his unbuilt work through to the capacity of his creative thought, the evolution of his main themes, the study of his final unbuilt works, his sensitivity to the arts as a whole and to everything beautiful. The 360 plates of illustrations provided form the basis of the study and analysis of his extensive unbuilt work.

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La infiltración de agua en el suelo y la recarga profunda del agua subterránea contenida en los acuíferos es un proceso lento en relación con otros fenómenos hidrológicos. La redacción de esta tesis ha pretendido contribuir al estudio de la influencia que el almacenamiento de la precipitación sólida en forma de manto de nieve y su eventual fusión puedan tener sobre dicho proceso en áreas de media montaña (1.000 – 2.000 m.) en las que con gran frecuencia se sitúan las cabeceras de los ríos peninsulares. Para ello se ha partido del análisis de las diferentes variables intervinientes durante un determinado periodo temporal y sobre un espacio geográfico concreto, por lo que su metodología es de naturaleza empírica. La extensión del periodo (2002/03 a 2010/11) ha venido condicionada por la disponibilidad de los valores de algunas de sus principales variables, como han sido el equivalente en agua de la nieve acumulada y los caudales procedentes de su fusión. Éstos se han obtenido como resultado de la aplicación del modelo ASTER, desarrollado en el programa de Evaluación de los Recursos Hídricos procedentes de la Innivación (ERHIN), calibrado – entre otros- con datos de precipitaciones, temperatura y caudales provenientes a su vez del Sistema Automático de Información Hidrológica (SAIH). Ambos programas fueron implantados por la Administración en las diferentes Confederaciones Hidrográficas y en determinados Organismos de cuenca actuales, en cuyo desarrollo participó el autor de esta tesis. En cuanto a la zona de estudio se ha procedido a su elección considerando las posibles áreas de media montaña en las que la presencia de la nieve fuera hidrológicamente significativa y estuvieran constituidas litológicamente por afloramientos permeables que no impidieran la infiltración en el terreno y la formación de acuíferos de cierta relevancia. El interés se centró discrecionalmente en la cuenca del Tajo, tanto por el carácter estratégico de la misma -como suministradora en la actualidad de excedentes a otras cuencas deficitarias- como por el valor representativo de sus condiciones climáticas y orográficas en relación con otras cuencas hidrográficas peninsulares. Para ello se partió de las cabeceras de ríos identificadas por el programa ERHIN por su interés nivológico para la implantación del modelo ASTER y de las Masas de Agua Subterráneas MASb (antes Unidades Hidrogeológicas UUHH) definidas en los planes hidrológicos. La intersección en el territorio de ambos criterios condujo, finalmente, a la zona del Alto Tajo, en la que se cumplen ambos requisitos. El tramo quedó concretado en el comprendido entre las cabeceras de los ríos Tajo y Guadiela y la cola de los embalses de Entrepeñas y Buendía respectivamente, puntos de cierre para la calibración llevada a cabo en la modelización ASTER. Gran parte de éste discurre, en su parte alta, sobre rocas carbonatadas (calizas y dolomías del Jurásico y Cretácico), relacionados con las MASb de Tajuña-Montes Universales, Molina de Aragón y Sigüenza-Maranchón. Los valores diarios de las reservas de agua en forma de nieve, evapotranspiración y caudales procedentes de la fusión se han obtenido a partir de los resultados del mencionado modelo, procediéndose al cálculo de la infiltración por balance hídrico durante el periodo de estudio considerado, teniendo en cuenta los valores de precipitación, evapotranspiración y aportaciones de caudales. Esto ha requerido el estudio previo de las condiciones hidrogeológicas de la zona seleccionada con objeto de conocer las posibles interconexiones subterráneas que pudieran alterar los saldos entre las variables intervinientes anteriormente citadas. Para ello se ha llevado a cabo la recopilación y análisis de la información hidrogeológica correspondiente a la documentación de los planes hidrológicos del Tajo (Plan Hidrológico de la cuenca del Tajo RD 1664/1998 y el actual Plan Hidrológico de la parte española de la Demarcación Hidrográfica del Tajo RD 270/2014) y de los estudios previos realizados por el organismo de cuenca y el Instituto Geológico y Minero de España (lGME) fundamentalmente. En relación con la MASb Tajuña-Montes Universales -cuya extensión supera la zona seleccionada- dichos estudios consideran su estructura geológica y distribución litológica, con intercalaciones impermeables que actúan como barreras, dividiendo a éstas en Subunidades e identificando las zonas de drenaje de sus respectivos acuíferos. También se ha considerado la documentación y estudios previos del Plan Hidrológico Nacional sobre las Unidades Hidrogeológicas compartidas entre ámbitos geográficos de diferentes planes hidrológicos. Se concluye que las divisorias hidrográficas de las cabeceras son sensiblemente coincidentes o abarcan las Subunidades Montes Universales meridionales, Priego, Cifuentes, Zaorejas, u Montes Universales septentrionales, que drenan hacia el Tajo/Guadiela (bien directamente, bien a través de afluentes como el Gallo, Ablanquejo, Cabrillas, Cuervo…), MASb Molina de Aragón, que drena al Tajo a través del río Gallo y MASb Sigüenza—Maranchón, que drena su parte correspondiente hacia el Tajo a través del Ablanquejo. Se descartan – salvo la pequeña salvedad del manantial de Cifuentes- las conexiones hidrogeológicas con otras MASb o Subunidades por lo que las cabeceras del Tajo y del Guadiela pueden considerarse como un Sistema independiente donde las precipitaciones no evaporadas escurren superficialmente o se infiltran y descargan hacia los embalses de Entrepeñas y Buendía. La cuantificación diaria y acumulada de los balances hídricos ha permitido calcular la evolución aproximada de las reservas de agua subterránea desde la fecha inicial. Originalmente los balances se realizaron de forma separada en las cabeceras del Tajo y del Guadiela, cuyos valores acumulados manifestaron una tendencia creciente en la primera y decreciente en la segunda. Dicha situación se equilibra cuando el balance se practica conjuntamente en ambas, apreciándose en la variación del volumen de agua subterránea una evolución acorde hidrológicamente con los ciclos de verano/invierno y periodos de sequía, manteniéndose sus valores medios a largo/medio plazo, poniendo en evidencia la existencia de interconexiones subterráneas entre ambas cuencas. El balance conjunto, agregando la cabecera del Tajuña (que también comparte los materiales permeables de la MASb Tajuña-Montes Universales) no reveló la existencia de nuevas interrelaciones hidrogeológicas que influyeran en los balances hídricos realizados Tajo/Guadiela, confirmando las conclusiones de los estudios hidrogeológicos anteriormente analizados. Se ha procedido a confrontar y validar los resultados obtenidos de la evolución de las reservas de agua subterránea mediante los siguientes procedimientos alternativos: - Cálculo de los parámetros de desagüe de la curva de agotamiento correspondiente al volumen de agua subterránea drenante hacia el Tajo/Guadiela. Éste se ha realizado a partir de las aportaciones mensuales entrantes en los embalses de Entrepeñas y Buendía durante los meses de junio, julio, agosto y septiembre, cuyos valores responden al perfil típico de descargas de un acuífero. A partir de éstos se ha determinado el volumen drenante correspondiente al primero de junio de cada año de la serie histórica considerada. - Determinación del caudal base por el método Wallingford y deducción de los volúmenes drenantes. Estimación de las recarga anuales - Cuantificación de la recarga anual por el método Sanz, Menéndez Pidal de Navascués y Távara. Se obtuvieron valores de recarga muy aproximados entre los calculados por los dos últimos procedimientos citados. Respecto a las reservas de agua subterránea almacenadas siguen una evolución semejante en todos los casos, lo que ha permitido considerar válidos los resultados conseguidos mediante balance hídrico. Confirmada su solidez, se han buscado correlaciones simples entre el volumen de las reservas subterráneas (como indicador estimativo del efecto de la infiltración) y los volúmenes procedentes de la fusión. La conclusión es que estos últimos no tienen un efecto determinante a escala anual sobre la infiltración,recarga y variación de los volúmenes de agua subterránea, frente al peso de otras variables (precipitación y evapotranspiración). No obstante se ha encontrado una buena correlación múltiple entre la recarga estimada y la precipitación eficaz (precipitación menos evapotranspiración) y fusión, que ha permitido cuantificar la contribución de esta última. Posteriormente se ha recurrido a la selección de los episodios más intensos de acumulación /fusión en las cabeceras del Tajo y Guadiela. Y se procedió a la comparación entre los resultados obtenidos por aplicación del modelo de simulación en los mismos periodos (normalmente de varios días de duración) con datos reales y con datos ficticios de temperatura que anularan o disminuyeran la presencia de nieve, apreciándose una gran sensibilidad del efecto de la temperatura sobre la evapotranspiración y estableciéndose nuevamente correlaciones lineales entre los volúmenes de fusión y el incremento de reservas subterráneas. Las mismas confirman el efecto “favorecedor” de la acumulación de agua en forma de nieve y su posterior licuación, sobre sobre la infiltración de agua en el suelo y almacenamiento subterráneo. Finalmente se establecieron varios escenarios climáticos (+1ºC; +3ºC; +1ºC y – 10% precipitación; y 3ºC – 10% precipitación) compatibles con las previsiones del IPCC para mediados y finales del presente siglo, determinándose mediante simulación ASTER los correspondientes valores de fusión. La correlación establecida a escala anual ha permitido evaluar el efecto de la disminución del volumen de fusión - en los diferentes escenarios – sobre la recarga, pronosticando un descenso de los caudales de estiaje y la desaparición del “efecto nieve” sobre la infiltración y recarga con un aumento de 3ºC de temperatura. Teniendo en cuenta las condiciones de representatividad de la zona elegida, resulta verosímil la extensión de las anteriores conclusiones a otras cabeceras fluviales enclavadas en áreas de media montaña situadas entre 1000 a 2000m y sus efectos aguas abajo.Water infiltration into the soil and groundwater recharge deep water in aquifers is slow relative to other hydrological phenomena. The wording of this thesis aims to contribute to the study of the influence that the storage of solid precipitation as snow cover and its eventual melting may have on this process in mid-mountain areas (1000 - 2,000 m) where very often the headwaters of the peninsular rivers are located. For this party analysis of the different variables involved has over a given time period and a particular geographical area, so that their methodology is empirical in nature. The extension of the period (2002/03 to 2010/11) has been conditioned by the availability of the values of some of its key variables, as were the water equivalent of the snow and flows from melting. These have been obtained as a result of the application of ASTER model, developed in the program Evaluation of Water Resources from the Innivation (ERHIN), calibrated - among others data of rainfall, temperature and flow from turn System Automatic Hydrological Information (SAIH). Both programs were implemented by the Administration in the different Water Boards and to undertakings for current basin, in which the author participated development of this thesis. As for the study area has proceeded at its option considering the possible areas of midmountain in the presence of snow outside hydrological meaningful and they were lithology consisting of permeable outcrops that did not prevent infiltration into the ground and forming aquifers of some significance. We were interested discretion in the Tagus basin, therefore the strategic nature of it, as currently supplying surplus to other basins deficit- as the representative value of its climate and terrain conditions in relation to other peninsular river basins . To do this we started from the headwaters identified by the ERHIN program for its implementation snow interest to the ASTER model and Ground Water Bodies MASb (before UUHH Hydrogeological Units) defined in hydrological plans. The intersection in the territory of both criteria led eventually to the Alto Tajo, in which both requirements are met. The section was finalized in the period between the headwaters of the Tagus and Guadiela rivers and reservoirs end Entrepeñas and Buendia respectively checking points for calibration performed in ASTER modeling. Much of it runs on carbonate rocks (limestones and dolomites of Jurassic and Cretaceous) related MASb of Tajuña -Montes Universal, Molina de Aragón and Sigüenza-Maranchón. The daily values of water reserves in the form of snow, evapotranspiration and flow from melting were obtained from the results of this model, proceeding to the calculation of infiltration water balance during the study period considered, taking into account values of precipitation, evapotranspiration and input flow. This has required the prior examination of the hydrogeological conditions of your required in order to know the possible underground interconnections that could alter the balance between the intervening variables aforementioned area. For this we have carried out the collection and analysis of hydrogeological information relevant documentation Tagus river management plans (Hydrological Plan Tajo Basin RD 1664/1998 and the current Hydrological Plan of the Spanish part of the River Basin Tagus RD 270/2014) and previous studies by the basin organization and the Geological Survey of Spain (IGME) mainly. Regarding the MASb Tajuña- Montes Universal - whose length exceeds the area selected - these studies consider its geological structure and lithology distribution with waterproof collations that act as barriers, dividing it into subunits and identifying areas draining their respective aquifers. It has also considered the documentation and previous studies of the National Hydrological Plan on shared among different geographical areas management plans Hydrogeological Units. We conclude that river dividing the headers are substantially coincident or covering Subunits southern Universal Montes, Priego Cifuentes, Zaorejas and northern Universal Mounts, which drain into the Tagus / Guadiela (either directly or through tributaries such as Gallo, Ablanquejo , whitecaps , Raven ...), MASb Molina de Aragón which drains through the Tajo del Gallo and MASb Sigüenza- Maranchón river that drains into the Tagus using the Ablanquejo . Discarded - except the small exception of spring Cifuentes -hydrogeological connections with other MASb or Subunits so the headwaters of the Tagus and Guadiela be considered as a separate system, where rainfall not evaporated runs on surface or infiltrates and eventually discharged into reservoirs Entrepeñas and Buendia. The daily and cumulative quantification of water balances allowed us to compute the approximate evolution of groundwater reserves from its initial date. Initially balances were performed separately in the headwaters of the Tagus and Guadiela, whose cumulative values showed an increasing trend in the first and decreasing in the second. This situation is balanced when the balance is practiced together in both , appreciating the change in volume of groundwater hydrological evolution commensurate with the cycles of summer / winter and drought periods , keeping their average long / medium term values and putting in shows the existence of underground interconnections between the two basins. The overall balance, adding header Tajuña (which also shares the permeable materials MASb Tajuña -Montes Universal ) did not reveal the existence of new hydrogeological interrelationships that influenced water balances made Tajo / Guadiela, confirming the findings of the hydrogeological studies previously analyzed. We proceeded to confront and validate the results of the evolution of groundwater reserves by the following alternative procedures: - Calculate the parameters drain depletion curve corresponding to the volume of groundwater draining into the Tajo / Guadiela. This has been made from monthly inflows in the reservoirs of Entrepeñas and Buendia during the months of June, July, August and September, whose values match the typical profile of an aquifer discharges. From these has been determined for the first of June each year of the time series considered drainage volume - Determination of base flow by Wallingford method and deduction of drainage volumes. Estimate of annual recharge - Quantification of the annual recharge by the method Sanz Menéndez Pidal of Navascués and Távara. Very approximate values recharge between calculated for the last two mentioned methods were obtained. Concerning groundwater reserves stored follow a similar pattern in all cases, allowing consider valid the results achieved through water balance. Confirmed its robustness, simple correlations were sought between the volume of groundwater reserves (as estimated indicator of the effect of infiltration) and volumes from the melting. The conclusion is that the latter do not have a decisive effect on the annual scale infiltration, recharge and variation in volumes of groundwater, against the weight of other variables (precipitation and evapotranspiration). However found a good multiple correlation between the estimated recharge and effective precipitation (precipitation minus evapotranspiration) and fusion, which allowed quantify the contribution of the latter. Subsequently it has resorted to the selection of the most intense episodes of accumulation / melting in the headwaters of the Tagus and Guadiela. And we proceeded to the comparison between the results obtained by application of the simulation model in the same periods (usually several days) with real data and fictitious temperature data to annul or decrease the presence of snow, appreciating a great sensitivity of the effect of temperature on evapotranspiration and establishing linear correlations between the volumes of melting and increased groundwater reserves again. They confirm the “flattering " effect of water accumulation as snow and subsequent liquefaction of the infiltration of water into the soil and underground storage. Finally various climate scenarios (+1ºC; +3ºC; +1ºC y – 10% precipitation; y 3ºC – 10% precipitation) were established consistent with IPCC projections for mid - to late - century, determined through simulation ASTER corresponding values of melting. The correlation established on an annual scale has allowed to evaluate the effect of decreasing the volume of melt - in different scenarios - on recharge, predicting a decline in low flows and the disappearance of "snow effect" on infiltration and recharge with an increase of 3°C temperature. Given the conditions of representativeness of the chosen area, plausible extension of the above findings to other landlocked headwaters in mid-mountain areas located between 1000 to 2000m and its downstream effects.

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The biogenesis of peptide hormone secretory granules involves a series of sorting, modification, and trafficking steps that initiate in the trans-Golgi and trans-Golgi network (TGN). To investigate their temporal order and interrelationships, we have developed a pulse–chase protocol that follows the synthesis and packaging of a sulfated hormone, pro-opiomelanocortin (POMC). In AtT-20 cells, sulfate is incorporated into POMC predominantly on N-linked endoglycosidase H-resistant oligosaccharides. Subcellular fractionation and pharmacological studies confirm that this sulfation occurs at the trans-Golgi/TGN. Subsequent to sulfation, POMC undergoes a number of molecular events before final storage in dense-core granules. The first step involves the transfer of POMC from the sulfation compartment to a processing compartment (immature secretory granules, ISGs): Inhibiting export of pulse-labeled POMC by brefeldin A (BFA) or a 20°C block prevents its proteolytic conversion to mature adrenocorticotropic hormone. Proteolytic cleavage products were found in vesicular fractions corresponding to ISGs, suggesting that the processing machinery is not appreciably activated until POMC exits the sulfation compartment. A large portion of the labeled hormone is secreted from ISGs as incompletely processed intermediates. This unregulated secretory process occurs only during a limited time window: Granules that have matured for 2 to 3 h exhibit very little unregulated release, as evidenced by the efficient storage of the 15-kDa N-terminal fragment that is generated by a relatively late cleavage event within the maturing granule. The second step of granule biogenesis thus involves two maturation events: proteolytic activation of POMC in ISGs and a transition of the organelle from a state of high unregulated release to one that favors intracellular storage. By using BFA, we show that the two processes occurring in ISGs may be uncoupled: although the unregulated secretion from ISGs is impaired by BFA, proteolytic processing of POMC within this organelle proceeds unaffected. The finding that BFA impairs constitutive secretion from both the TGN and ISGs also suggests that these secretory processes may be related in mechanism. Finally, our data indicate that the unusually high levels of unregulated secretion often associated with endocrine tumors may result, at least in part, from inefficient storage of secretory products at the level of ISGs.

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A number of recent studies have, by necessity, placed a great deal of emphasis on the dental evidence for Paleogene anthropoid interrelationships, but cladistic analyses of these data have led to the erection of phylogenetic hypotheses that appear to be at odds with biogeographic and stratigraphic considerations. Additional morphological data from the cranium and postcranium of certain poorly understood Paleogene primates are clearly needed to help test whether such hypotheses are tenable. Here we describe humeri attributable to Proteopithecus sylviae and Catopithecus browni, two anthropoids from late Eocene sediments of the Fayum Depression in Egypt. Qualitative and morphometric analyses of these elements indicate that humeri of the oligopithecine Catopithecus are more similar to early Oligocene propliopithecines than they are to any other Paleogene anthropoid taxon, and that Proteopithecus exhibits humeral similarities to parapithecids that may be symplesiomorphies of extant (or “crown”) Anthropoidea. The humeral morphology of Catopithecus is consistent with certain narrowly distributed dental apomorphies—such as the loss of the upper and lower second premolar and the development of a honing blade for the upper canine on the lower third premolar—which suggest that oligopithecines constitute the sister group of a clade containing propliopithecines and Miocene-Recent catarrhines and are not most closely related to Proteopithecus as has recently been proposed.

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MetaFam is a comprehensive relational database of protein family information. This web-accessible resource integrates data from several primary sequence and secondary protein family databases. By pooling together the information from these disparate sources, MetaFam is able to provide the most complete protein family sets available. Users are able to explore the interrelationships among these primary and secondary databases using a powerful graphical visualization tool, MetaFamView. Additionally, users can identify corresponding sequence entries among the sequence databases, obtain a quick summary of corresponding families (and their sequence members) among the family databases, and even attempt to classify their own unassigned sequences. Hypertext links to the appropriate source databases are provided at every level of navigation. Global family database statistics and information are also provided. Public access to the data is available at http://metafam.ahc.umn.edu/.

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Compelling evidence has accumulated over the last several years from our laboratory, as well as others, indicating that central hyperactive states resulting from neuronal plastic changes within the spinal cord play a critical role in hyperalgesia associated with nerve injury and inflammation. In our laboratory, chronic constriction injury of the common sciatic nerve, a rat model of neuropathic pain, has been shown to result in activation of central nervous system excitatory amino acid receptors and subsequent intracellular cascades including protein kinase C translocation and activation, nitric oxide production, and nitric oxide-activated poly(ADP ribose) synthetase activation. Similar cellular mechanisms also have been implicated in the development of tolerance to the analgesic effects of morphine. A recently observed phenomenon, the development of “dark neurons,” is associated with both chronic constriction injury and morphine tolerance. A site of action involved in both hyperalgesia and morphine tolerance is in the superficial laminae of the spinal cord dorsal horn. These observations suggest that hyperalgesia and morphine tolerance may be interrelated at the level of the superficial laminae of the dorsal horn by common neural substrates that interact at the level of excitatory amino acid receptor activation and subsequent intracellular events. The demonstration of interrelationships between neural mechanisms underlying hyperalgesia and morphine tolerance may lead to a better understanding of the neurobiology of these two phenomena in particular and pain in general. This knowledge may also provide a scientific basis for improved pain management with opiate analgesics.

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Complex systems in causal relationships are known to be circular rather than linear; this means that a particular result is not produced by a single cause, but rather that both positive and negative feedback processes are involved. However, although interpreting systemic interrelationships requires a language formed by circles, this has only been developed at the diagram level, and not from an axiomatic point of view. The first difficulty encountered when analysing any complex system is that usually the only data available relate to the various variables, so the first objective was to transform these data into cause-and-effect relationships. Once this initial step was taken, our discrete chaos theory could be applied by finding the causal circles that will form part of the system attractor and allow their behavior to be interpreted. As an application of the technique presented, we analyzed the system associated with the transcription factors of inflammatory diseases.

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Objetivo: Describir la experiencia cultural, interpersonal y personal de los adultos mayores con enfermedades crónicas e identificar las estrategias y redes de apoyo que utilizan en su entorno cotidiano para gestionar la enfermedad. Método: Se desarrolló un metaestudio tipo metaanálisis cualitativo. La estrategia metodológica constó de cuatro etapas: Búsqueda bibliográfica, Categorización de los estudios, Evaluación de la calidad metodológica y Análisis de resultados. Resultados: Se obtuvo una muestra bibliográfica de 22 estudios de naturaleza cualitativa. Los hallazgos se organizaron en 4 categorías: Compresión del padecimiento, Autogestión en el cotidiano, Percepción de los Servicios de Salud y Cotidiano del cuidador. Conclusiones: El esfuerzo de los adultos mayores por alcanzar un nuevo equilibrio social y personal se articula en las estrategias de autogestión que utilizan en su día a día para afrontar sus padecimientos. Las interrelaciones con los servicios de salud, familia y redes de apoyo son fundamentales para gestionar la cronicidad.

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To counteract the powerful anti-Europe sentiments swirling throughout the EU today and to motivate EU citizens to vote in a constructive spirit in the upcoming European elections, Karel Lannoo argues in this commentary that the functioning of the EU institutions needs to be openly discussed and proposals need to be aired for improving the decision-making process to render it more transparent and democratic. This process would encompass, in his view, the proper role and functioning of the European Commission, the European Parliament and the member states in the EU Council and the interrelationships between these institutions.

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In this new CEPS Commentary, a team of climate and energy specialists argue that a reliable system of climate and energy governance in the EU would certainly need to go beyond the issues that are identified in the 2030 framework for climate and energy and the Energy Union. In their view, such a system would consist of no less than seven complex areas, which they proceed to outline and discuss their interrelationships. To ensure that these areas are dealt with in an integrated manner, they recommend that the European Commission creates a roadmap – possibly in the form of a Communication – that would indicate the direction, interactions and a timeline for their adoption.

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Orientation and geometry of pores as well as sediment compressibility can be approximated by determining the shrinkage behavior of standardized samples. The sections investigated show that these measurements are influenced by changing sediment composition. This is also well documented by the relationship between void ratio and overburden pressure. Median pore-diameter calculations clearly reflect both sediment composition and compaction.

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During Legs 127 and 128, we found a systematic error in the index property measurements, in that the wet bulk density, grain density, and porosity did not satisfy well-established interrelationships. We have found that an almost constant difference exists between the weight of water lost during drying and the volume of water lost. This discrepancy is independent of volume or water content of the sample. The water losses should be equal because the density of water is close to 1.0 g/cm**3. The pycnometer wet volume measurement has been identified as the source of the systematic error. The wet volume on average is 0.2 cm**3 too low. For the rare cases when the water content is negligible, there is no offset. The source of the wet volume error results from the partial vapor pressure of water in the pycnometer cell. Newly corrected tables of index properties measured during Legs 127 and 128 are included. The corrected index properties are internally consistent. The data are in better agreement with theoretical models that relate the index properties to other physical properties, such as thermal conductivity and acoustic velocity. In future, a standard volume sampler should be used, or the wet volume should be calculated from the dry volume and the water loss by weight.

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Distributional patterns of glaciological parameters at the Colle Gnifetti core drilling site are described and their interrelationships are brietly discussed. Observations within a stake network established in 1980 furnish information about snow accumulation (short term balance), submergence velocity of ice tlow (long term balance), ram hardness (melt layer stratigraphy), and firn temperature. In addition, a numerical model was used to estimate local variations of available radiant energy. Melt layer formation is considerably more intensive on the south facing parts of the firn saddie where incoming radiation is high. These melt layers seem to effectively protect some of the fallen snow from wind erosion. As a result, balance ist up to one order of magnitude larger on south facing slopes. Heat applied to the surface is therefore positively correlated with balance, whereas the relation between solar radiation and firn temperature is less dear. Distributional patterns of submergence velocity confirm that the observed spatial variability of surface balance is representative for longer time periods and greatly intluences the time scale and the stratigraphy of firn and ice cores from Colle Gnifetti.

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Thesis (Ph.D.)--University of Washington, 2016-06