Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels

Many blockers of Na+ and K+ channels act by blocking the pore from the intracellular side. For Shaker K+ channels, such intracellular blockers vary in their functional effect on slow (C-type) inactivation: Some blockers interfere with C-type inactivation, whereas others do not. These functional differences can be explained by supposing that there are two overlapping “subsites” for blocker binding, only one of which inhibits C-type inactivation through an allosteric effect. We find that the ability to bind to these subsites depends on specific structural characteristics of the blockers, and correlates with the effect of mutations in two distinct regions of the channel protein. These interactions are important because they affect the ability of blockers to produce use-dependent inhibition.

Thomas à Kempis and the Brothers of common life.

Mode of access: Internet.

Banakanutʻean dar : k��nnakan tesutʻiwn Kristonēakan drutʻean /

The biography of Thomas Paine, 1737-1809 and translation of his "Age of reason" and its interpretation.

A new Ploughman's tale: Thomas Hoccleve's legend of the Virgin and her sleeveless garment, with a spurious link.

Mode of access: Internet.

Thomas De Quincey's theory of literature.

Presented as a doctoral dissertation at the University of Michigan in 1937. This revision, unfinished at the time of the author's death, has been completed by C.D. Thorpe and Paul Mueschke.

The canals of Canada : their prospects and influence : written for a premium offered by His Excellency the Earl of Elgin and Kincardine, K. T., governor general of British North America, etc., etc., etc. /

En tête du titre: Prize essay.

Thomas Fitz-Gerald, the Lord of Offaley. A romance of the sixteenth century.

Summers, Gothic Bib., p. 533.

Some account of the life and writings of ... Thomas Sprat ... With a true copy of his last will and testament.

From the library of C.K. Ogden.

Hē Kainē Diathēk�� : the Greek Testament, with English notes, critical, philological, and exegetical /

Mode of access: Internet.

Thomas Carlyle,

Reprinted from the Carlyle number (May, 1902) of the London Bookman.

Grimm's law: a study, or hints towards an explanation of the so-called "lautverschiebung"; to which are added some remarks on the primitive Indo-European k and several appendices.

Mode of access: Internet.

University of Michigan Men's Basketball Team, 1978

Back Row: Joel Thompson, K. Michael Robinson, Len Lillard, co-captain Phil Hubbard, Tom Bergen, Paul Heuerman, Alan Hardy

Middle Row: asst. coach Bill Frieder, head coach Johnny Orr, Marty Bodnar, Joh Lozier, Mark Bodnar, asst. coach Jim Boyce, asst. coach Dan Fife

Front Row: Mngr. Mitchell Kaufman, Cornel Williams, Thomas Staton, co-captain David Baxter, Mike McGee, John Johnson, ?, mngr. John Anderson