Nitric oxide and the release of lipoprotein lipase from white adipose tissue

Background/Aim: Lipoprotein lipase (LPL) is the main enzyme responsible for the distribution of circulating triacylglycerides in tissues. Its regulation via release from active sites in the vascular endothelium is poorly understood. In a previous study we reported that in response to acute immobilization (IMMO), LPL activity rapidly increases in plasma and decreases in white adipose tissue (WAT) in rats. In other stress situations IMMO triggers a generalized increase in nitric oxide (NO) production. Methods/Results: Here we demonstrate that in rats: 1) in vivo acute IMMO rapidly increases NO concentrations in plasma 2) during acute IMMO the WAT probably produces NO via the endothelial isoform of nitric oxide synthase (eNOS) from vessels, and 3) epididymal WAT perfused in situ with an NO donor rapidly releases LPL from the endothelium. Conclusion: We propose the following chain of events: stress stimulus / rapid increase of NO production in WAT (by eNOS) / release of LPL from the endothelium in WAT vessels. This chain of events could be a new mechanism that promotes the rapid decrease of WAT LPL activity in response to a physiological stimulus.

Allocation of added selenium in lettuce and its impact on roots

Selostus: Seleenin jakautuminen salaatin versoihin ja vaikutus juuriin

Sankareita, syrjäytettyjä ja selkään puukotettuja

Kirja-arvio

Narratiivisuus folkloristiikassa

Teemanumero 2007

Tarinamatkalla Islannissa : 5th Celtic-Nordic-Baltic Folklore Symposium on Folk Legends, Reykjavik 14.-18.6.2005

Ajankohtaista

Mä en sit siihe sanonu mitään : raportit sanomatta jättämisestä ja evidentiaalinen partikkeli sit(te(n)) keskustelun kertomuksissa

E. Summary: Reports about saying nothing and the evidential particle sit(te(n)) in conversational narratives