Studies in the packing industry [by] the Bureau of business and economic research in co-operation with the Local community research committee of the University of Chicago and the Institute of American meat packers.

Mode of access: Internet.

With the fathers; studies in the history of the United States,

The Monroe doctrine.--The third-term tradition.--The political depravity of the fathers.--The riotous career of the Know-nothings.--The framers and the framing of the Constitution.--Washington's inauguration.--A century of constitutional interpretation.--A century's struggle for silver.--Is sound finance possible under popular government?--Franklin in France.--How the British left New York.--The struggle for territory.--Four centuries of progress.

Geologic studies in the basin and range-Colorado Plateau transition in southeastern Nevada, southwestern Utah, and northwestern Arizona, 1995 /

Mode of access: Internet.

Studies in the cost

Mode of access: Internet.

Studies in the science and history of music.

Mode of access: Internet.

The Director, a weekly literary journal: containing I. Essays, on subjects of literature, the fine arts and manners. II. Bibliographana. Account of rare and curious books and of the book sales in this country, from the close of the seventeenth century. III. Royal institution. Analyses of the lectures delivered weekly. IV. British Gallery. Description of the principal pictures exhibited ... v. 1-2: Jan. 24-July 4, 1807.

"The biographical part was written by Mr. Dibdin."--Lowndes, The bibliographer's manual of English literature.

Studies in the social sciences. ... .

Mode of access: Internet.

University of Wisconsin studies in the social sciences and history.

Mode of access: Internet.

Studies in the literary relations of England and Germany in the sixteenth century.

Introduction.--Lyrics--Polemical dialogues.--The Latin drama.--The Faustus cycle.--The Ulenspiegel cycle.--The ship of fools.--Grobianus and Grobianism.

University of Iowa studies in the social sciences.

Mode of access: Internet.

Some studies in the topography of the cathedral close, Exeter,

Mode of access: Internet.

Studies in the Cartesian philosophy

The problem of Descartes -- The method of Descartes -- The metaphysics of Descartes -- The Cartesian principles in Spinoza and Leibniz -- The Cartesian principles in Locke -- Hume's criticism of the Cartesian principles -- The transition to Kant.

What is the best size descriptor to use for pharmacokinetic studies in the obese?

The prevalence of obesity in the western world is dramatically rising, with many of these individuals requiring therapeutic intervention for a variety of disease states. Despite the growing prevalence of obesity there is a paucity of information describing how doses should be adjusted, or indeed whether they need to be adjusted, in the clinical setting. This review is aimed at identifying which descriptors of body size provide the most information about the relationship between dose and concentration in the obese. The size descriptors, weight, lean body weight, ideal body weight, body surface area, body mass index, fat-free mass, percent ideal body weight, adjusted body weight and predicted normal body weight were considered as potential size descriptors. We conducted an extensive review of the literature to identify studies that have assessed the quantitative relationship between the parameters clearance (CL) and volume of distribution (V) and these descriptors of body size. Surprisingly few studies have addressed the relationship between obesity and CL or V in a quantitative manner. Despite the lack of studies there were consistent findings: (i) most studies found total body weight to be the best descriptor of V. A further analysis of the studies that have addressed V found that total body weight or another descriptor that incorporated fat mass was the preferred descriptor for drugs that have high lipophilicity; (ii) in contrast, CL was best described by lean body mass and no apparent relationship between lipophilicity or clearance mechanism and preference for body size descriptor was found. In conclusion, no single descriptor described the influence of body size on both CL and V equally well. For drugs that are dosed chronically, and therefore CL is of primary concern, dosing for obese patients should not be based on their total weight. If a weight-based dose individualization is required then we would suggest that chronic drug dosing in the obese subject should be based on lean body weight, at least until a more robust size descriptor becomes available.