977 resultados para Gallego, Julián


Relevância:

10.00% 10.00%

Publicador:

Resumo:

Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic at diagnosis, new non-invasive approaches are needed to determine the hepatic lipid content in terms of diagnosis, treatment and control of disease progression. Here, we investigated the potential of magnetic resonance imaging (MRI) to quantitate and monitor the hepatic triglyceride concentration in humans. Methods: A prospective study of diagnostic accuracy was conducted among 129 consecutive adult patients (97 obesity and 32 non-obese) to compare multi-echo MRI fat fraction, grade of steatosis estimated by histopathology, and biochemical measurement of hepatic triglyceride concentration (that is, Folch value). Results: MRI fat fraction positively correlates with the grade of steatosis estimated on a 0 to 3 scale by histopathology. However, this correlation value was stronger when MRI fat fraction was linked to the Folch value, resulting in a novel equation to predict the hepatic triglyceride concentration (mg of triglycerides/g of liver tissue = 5.082 + (432.104 * multi-echo MRI fat fraction)). Validation of this formula in 31 additional patients (24 obese and 7 controls) resulted in robust correlation between the measured and estimated Folch values. Multivariate analysis showed that none of the variables investigated improves the Folch prediction capacity of the equation. Obese patients show increased steatosis compared to controls using MRI fat fraction and Folch value. Bariatric surgery improved MRI fat fraction values and the Folch value estimated in obese patients one year after surgery. Conclusions: Multi-echo MRI is an accurate approach to determine the hepatic lipid concentration by using our novel equation, representing an economic non-invasive method to diagnose and monitor steatosis in humans.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

139 p.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

A presente pesquisa comparativa mostra por que ao longo do século XX se consolidou o sindicalismo docente de base na Argentina, no Brasil e no México e explica as particularidades nacionais desse processo. A categoria sindicalismo docente de base, desenvolvida no contexto da presente investigação, pretende captar um fenômeno que aparece com clareza na segunda metade do século XX: as organizações de professores tem reivindicações fundamentalmente trabalhistas, legitimidade para organizar medidas coletivas de pressão sobre os governos (particularmente greves) e, além disso, a base da categoria tem uma importante gravitação sobre as entidades que pretendem representá-la. A comparação histórica e sociológica permite identificar três processos sucessivos que foram fundamentais para a afirmação do sindicalismo docente de base: a propagação das associações da categoria, a implantação das organizações na base docente e, finalmente, a consolidação do sindicalismo docente de base. Esses processos constituem conjunturas críticas e as características particulares que as práticas sindicais adquiriram nesses contextos tendem a se reproduzir basicamente por dois mecanismos: a tradição sindical e a regulamentação estatal da atividade sindical e do trabalho docente. As práticas sindicais docentes são estruturadas pelas características dos professores e das suas condições de existência. Também são mediadas pelas particularidades das organizações docentes, pela tradição sindical e pela ação governamental perante a atividade reivindicativa e associativa dos trabalhadores. A reconstrução desses elementos estruturantes e dessas mediações contribui para explicar quando as conjunturas críticas aconteceram e quais características particulares apresentaram. No México, a situação política geral e a relação que estabeleceram os quadros docentes com os governos pós-revolucionários em particular, permitiram uma rápida consolidação das associações docentes e uma implantação na base através do Estado na primeira metade do século. Também nesse período, no México, o professorado perdeu parcialmente as suas características femininas e o confronto com as autoridades como forma de pressão coletiva legitimou-se. Isso contrasta com os outros países, nos quais a organização da categoria se generalizou sem apoio estatal decisivo. A concentração da categoria em escolas e cidades fortaleceu a afirmação do sindicalismo docente de base cujas consequências já podem ser vistas nos três países em finais da década de 1950. Nesse contexto, as organizações docentes argentinas se implantaram na base (depois de que falisse a tentativa do governo de implantar o sindicalismo docente através do Estado), mas as brasileiras não. As organizações brasileiras só se implantariam na base após 1978. Processos que na década de 1950 já estavam em desenvolvimento (como a consolidação do professor como trabalhador de base de sistemas burocráticos dirigidos por especialistas, a regulamentação e burocratização da carreira, a perda de importância das recompensas simbólicas como incentivo para exercer o professorado) e outros que apareceriam nas décadas seguintes (como a incorporação crescente da mulher no mercado de trabalho, a radicalização do movimento estudantil e o recrutamento do professorado entre as camadas mais pobres da população) explicam a consolidação do sindicalismo docente de base entre as décadas de 1970 e 1980

Relevância:

10.00% 10.00%

Publicador:

Resumo:

The purpose of the present work was both to analyze composition of Spanish celiac women and to study the food habits and gluten-free diet of these celiac patients, in order to determine whether they achieve a balanced and healthy diet as well as to highlight nutritional qualitative and/or quantitative differences. 54 adult celiac women (34 +/- 13 years) took part in the six-month study. Height, weight and body composition were measured. An analysis of energy consumption and of the macronutrient distribution of their diet was carried out. Their fulfillment of micronutrient intake recommendations was verified. Participants showed a Body Mass Index of 21.6 +/- 2.4 kg/m(2). Energy Intake was slightly lower than the Dietary Reference Intakes. Excessive protein apart from over-consumption of fat was observed. More than three quarters of participants consumed meat in excess. Carbohydrate consumption along with that of fiber was below recommended levels. Vitamin D, iron, and iodine had a low percentage of recommendation compliance. In general, participants followed the recommendations of dairy products and fruit intake whereas vegetable consumption was not enough for the vast majority. We conclude that although the diet of celiac women does not differ much from the diet of general population, some considerations, such as reducing fat and protein consumption and increasing fiber intake, must be taken into account.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (CS-KP) producing CTX-M-15, were also involved in the outbreak. Results: From October 2010 to December 2012 a total of 62 CR-KP and 23 CS-KP were isolated from clinical samples of 42 patients (22 had resistant isolates, 14 had susceptible isolates, and 6 had both CR and CS isolates). All patients had underlying diseases and 17 of them (14 patients with CR-KP and 3 with CS-KP) had received carbapenems previously. The range of carbapenem MICs for total isolates were: imipenem: 2 to >32 mu g/ml vs. <2 mu g/ml; meropenem: 4 to >32 mu g/ml vs. <2 mu g/ml; and ertapenem: 8 to >32 mu g/ml vs. <2 mu g/ml. All the isolates were also resistant to gentamicin, ciprofloxacin, and cotrimoxazole. Both types of isolates shared a common PFGE pattern associated with the multilocus sequence type 101 (ST101). The bla(CTX-M-15) gene was detected in all the isolates, whereas the bla(OXA-48) gene was only detected in CR-KP isolates on a 70 kb plasmid. Conclusions: The clonal spread of K. pneumoniae ST101 expressing the OXA-48 and CTX-M-15 beta-lactamases was the cause of an outbreak of CR-KP infections. CTX-M-15-producing isolates lacking the blaOXA-48 gene coexisted during the outbreak.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

[ES]A través de este Trabajo de Fin de Grado (TFG) pretendo explorar los roles de las diferentes ideologías éticas y el creciente interés por estas ideologías en la actividad comercial de las empresas a lo largo de la última década.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

[ES] El objetivo principal que se busca con este trabajo es analizar los diferentes sistemas de tecnología utilizados en la actividad empresarial y más concretamente en la gestión de los equipos comerciales. Además, también se pretende estudiar cuál es el grado de aceptación por parte de estos comerciales respecto a las innovaciones tecnológicas que tienen que utilizar cada día en su trabajo. Como objetivos secundarios, se busca averiguar qué herramientas tecnológicas son las más utilizadas por los comerciales en su trabajo, así como cuáles son las que más usan con los clientes de la empresa. También se quiere conocer cuál es la percepción y opinión de este colectivo de trabajadores respecto a la tecnología en general y sobre todo con aquella que tienen que utilizar en su trabajo y averiguar si piensan si esta les es útil y les ayuda a mejorar su productividad.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

This document aims to describe an update of the implementation of the J48Consolidated class within WEKA platform. The J48Consolidated class implements the CTC algorithm [2][3] which builds a unique decision tree based on a set of samples. The J48Consolidated class extends WEKA’s J48 class which implements the well-known C4.5 algorithm. This implementation was described in the technical report "J48Consolidated: An implementation of CTC algorithm for WEKA". The main, but not only, change in this update is the integration of the notion of coverage in order to determine the number of samples to be generated to build a consolidated tree. We define coverage as the percentage of examples of the training sample present in –or covered by– the set of generated subsamples. So, depending on the type of samples that we use, we will need more or less samples in order to achieve a specific value of coverage.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

The CTC algorithm, Consolidated Tree Construction algorithm, is a machine learning paradigm that was designed to solve a class imbalance problem, a fraud detection problem in the area of car insurance [1] where, besides, an explanation about the classification made was required. The algorithm is based on a decision tree construction algorithm, in this case the well-known C4.5, but it extracts knowledge from data using a set of samples instead of a single one as C4.5 does. In contrast to other methodologies based on several samples to build a classifier, such as bagging, the CTC builds a single tree and as a consequence, it obtains comprehensible classifiers. The main motivation of this implementation is to make public and available an implementation of the CTC algorithm. With this purpose we have implemented the algorithm within the well-known WEKA data mining environment http://www.cs.waikato.ac.nz/ml/weka/). WEKA is an open source project that contains a collection of machine learning algorithms written in Java for data mining tasks. J48 is the implementation of C4.5 algorithm within the WEKA package. We called J48Consolidated to the implementation of CTC algorithm based on the J48 Java class.