Oxidative Stress in Maternal Blood and Placenta From Mild Diabetic Rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cardiac Energy Metabolism and Oxidative Stress Biomarkers in Diabetic Rat Treated with Resveratrol

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Diabete moderado induzido em diferentes fases da vida de ratas Wistar: repercussões na reprodução materna e na freqüência de anomalias fetais

Experimental models are necessary to elucidate pathophysiological mechanisms not yet understood in humans. To evaluate the repercussions of the diabetes, considering two methodologies, on the pregnancy of Wistar rats and on the development of their offspring. In the 1st induction, female offspring were distributed into two experimental groups: Group streptozotocin (STZ, n=67): received the β-cytotoxic agent (100mg STZ/kg body weight - sc) on the 1st day of the life; and Non-diabetic Group (ND, n=14): received the vehicle in a similar time period. In the adult life, the animals were mated. After a positive diagnosis of pregnancy (0), female rats from group STZ presenting with lower glycemia than 120 mg/dL received more 20 mg STZ/kg (ip) at day 7 of pregnancy (2nd induction). The female rats with glycemia higher than 120mg/dL were discarded because they reproduced results already found in the literature. In the mornings of days 0, 7, 14 and 21 of the pregnancy glycemia was determined. At day 21 of pregnancy (at term), the female rats were anesthetized and killed for maternal reproductive performance and fetal development analysis. The data were analyzed using Student-Newman-Keuls, Chi-square and Zero-inflated Poisson (ZIP) Tests (p<0.05). STZ rats presented with increased rates of pre (STZ=22.0%; ND=5.1%) and post-implantation losses (STZ=26.1%; ND=5.7%), reduced rates of fetuses with appropriate weight for gestational age (STZ=66%; ND=93%) and reduced degree of development (ossification sites). Conclusion: Mild diabetes led a negative impact on maternal reproductive performance and caused intrauterine growth restriction and impaired fetal development

Efeito da atividade física na sensibilidade à insulina e no sinal insulínico em ratos com doença periodontal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação da fosforilação da AKT e do conteúdo da proteína transportadora de glicose GLUT4 em tecido muscular esquelético de ratos adultos, proles de ratas com doença periodontal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Changes in the TNF-alpha/IL-10 ratio in hyperglycemia-associated pregnancies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Low-Level Fluoride Exposure Increases Insulin Sensitivity in Experimental Diabetes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Improvement of the physical performance is associated with activation of NO/PGC-l alpha/mtTFA signaling pathway and increased protein expressions of electron transport chain in gastrocnemius muscle from rats supplemented with L-arginine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of inhaling cymbopogon martinii essential oil and geraniol on serum biochemistry parameters and oxidative stress in rats

The effects of the inhalation of Cymbopogon martinii essential oil (EO) and geraniol on Wistar rats were evaluated for biochemical parameters and hepatic oxidative stress. Wistar rats were divided into three groups (n = 8): G1 was control group, treated with saline solution; G2 received geraniol; and G3 received C. martinii EO by inhalation during 30 days. No significant differences were observed in glycemia and triacylglycerol levels; G2 and G3 decreased (P < 0.05) total cholesterol level. There were no differences in serum protein, urea, aspartate aminotransferase activity, and total hepatic protein. Creatinine levels increased in G2 but decreased in G3. Alanine aminotransferase activity and lipid hydroperoxide were higher in G2 than in G3. Catalase and superoxide dismutase activities were higher in G3. C. martinii EO and geraniol increased glutathione peroxidase. Oxidative stress caused by geraniol may have triggered some degree of hepatic toxicity, as verified by the increase in serum creatinine and alanine aminotransferase. Therefore, the beneficial effects of EO on oxidative stress can prevent the toxicity in the liver. This proves possible interactions between geraniol and numerous chemical compounds present in C. martinii EO.

Rutin administration attenuates myocardial dysfunction in diabetic rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Exenatide and sitagliptin decrease interleukin 1β, matrix metalloproteinase 9, and nitric oxide synthase 2 gene expression but does not reduce alveolar bone loss in rats with periodontitis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência do treinamento físico aeróbio sobre os biomarcadores cardiovasculares e endócrino-inflamatórios em mulheres normotensas e hipertensas no pós-menopausa

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Níveis plasmáticos de nitrito/nitrato, GMPc e cortisol em mulheres normotensas e hipertensas após a menopausa: efeito crônico do exercício físico e exposição aguda à L-arginina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Anestesia total intravenosa (ATI) para herniorrafias umbilicais em bezerros

The total intravenous anesthesia (TIVA) is an option for some surgeries in bovines for fields. The aim of this study was to evaluate blood gases effects, cardiorespiratory and glycemia on calves submitted the umbilical herniorraphy. We used eight calves aged from 9 ± 4 months, weighting 111 ± 43 kg. The animals were pre-treated with xylazine (0.05 mg/kg IV) and after 15 minutes was administered ketamine (2.0 mg/kg IV) followed by the continuous infusion of xylazine (0.05 mg/ml), guaifenesin (50 mg/mL) and ketamine (1mg/ml) at a rate of infusion of 2mL/kg/hour. The blood gases and glucose samples were collected immediately before the MPA (MB) and the 5, 40 and 80 after the starting of TIVA (M5, M40 e M80). The other variables were measured in MB, 15 minutes after the MPA (Mx) and every 10 minutes after the starting of TIVA, entiring 80 minutes. The heart rate was higher in MB than in the other stages (p <0.05) and respiratory rate increased in M20 and M50 compared to MB and Mx (p <0.05). The PvCO2 increased while PaO2 decreased in M40 and M80, for MB (p <0.05), PVCO2 in M80 was lower than in MB (p <0.05). The pHv was smaller in M80 than M5 and MB (p <0.05), and HCO3 was lower in MB (p <0.05) compared to the others. The glucose was higher in M40 and M80 and M5 for MB (p <0.05). The recovery time was 152 ± 60 minutes after the end of the administration of the infusion of anesthetics. It was conclude that the anesthetic technique employed promoted respiratory depression, increased blood glucose and prolonged period of anesthetic recovery in calves.