Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progression was characterized by two principal pathogenic mechanisms. Initially, AE expression modified the lineage potential of haematopoietic stem cells (HSCs), resulting in the selective expansion of the myeloid compartment at the expense of normal erythro- and lymphopoiesis. This lineage skewing was followed by a second substantial rewiring of transcriptional networks occurring in the trajectory to manifest leukaemia. We also find that both HSC and lineage-restricted granulocyte macrophage progenitors (GMPs) acquired leukaemic stem cell (LSC) potential being capable of initiating and maintaining the disease. Finally, our data demonstrate that long-term expression of AE induces an indolent myeloproliferative disease (MPD)-like myeloid leukaemia phenotype with complete penetrance and that acute inactivation of AE function is a potential novel therapeutic option.

National Disability Strategy Towards 2016 Strategic Document

National Disability Strategy Towards 2016 Strategic Document Click here to download PDF 31kb

Gender-based Violence: a resource document for services and organisations working with and for minority ethnic women

Gender-based Violence: a resource document for services and organisations working with and for minority ethnic women Click here to download PDF 492kb This is a publication of the Womens Health Council

Inca expansion and parasitism in the Lluta Valley: preliminary data

Assessing the impact of cultural change on parasitism has been a central goal in archaeoparasitology. The influence of civilization and the development of empires on parasitism has not been evaluated. Presented here is a preliminary analysis of the change in human parasitism associated with the Inca conquest of the Lluta Valley in Northern Chile. Changes in parasite prevalence are described. It can be seen that the change in life imposed on the inhabitants of the Lluta Valley by the Incas caused an increase in parasitism.

Desenvolupament d'una aplicació que realitzi de forma automatitzada lainserció de referències bibliogràfiques en un document OpenOffice.

Desenvolupament d'una aplicació que realitzi de forma automatitzada lainserció de referències bibliogràfiques en un document OpenOffice. Aquestes referències formaran part d¿un document extern que serà validat per una DTD, per tant, de forma implícita s¿estudiarà el format XML per a l¿elaboració estructuradad¿informació i el format DTD per la seva validació.

Usabilidad de PDA's

Anàlisi dels PDA, des del punt de vista de la facilitat d'ús i el disseny centrat en l'usuari, per comprovar fins a quin punt es té en compte aquesta expansió.

Analizador de red (sniffer) en entorno GNU

Aquest projecte mira de reflectir els coneixements adquirits en les assignatures pròpies de la carrera, com ara Fonaments de programació, Sistemes operatius i Ampliació de sistemes operatius, Xarxes, Estructura de xarxes de computadors i Seguretat en xarxes de computadors.

Construcción de un SIG para la Gestión de Rutas en Caminos no Cartografiados

En aquest projecte es construeix un Sistema d'Informació Geogràfica (SIG) que permet ampliar la cartografia estàndard del territori català amb les rutes que han seguit, per camins no cartografiats, els vehicles d'una empresa veterinària.

The London health inequalities forecast: Technical document

This paper describes the data and methods used in the London health inequalities forecast: A briefing on inequalities in life expectancy and deaths from cancers, heart disease and stroke in London. Links to relevant data sources and further information are also provided where possible.

Spearhead Health Inequalities Intervention Tool: technical document

This document describes the technical detail behind the Spearhead Health Inequalities Intervention Tool.

Health inequalities intervention tool: technical document

This paper describes the data and methods used in the Health inequalities intervention tool to calculate the effect of four interventions on life expectancy.

Construcció d'una eina automàtica per extreure informació d'un document OpenOffice

Aquest Projecte de Final de Carrera consisteix en estudiar el format dels fitxers OpenOffice i extreure'n certa informació continguda en els documents per satisfer una necessitat plantejada per la recentment constituïda Agencia Catalana de Seguretat, mitjançant una eina de software creada per a tal fi.

Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.

BACKGROUND: Activation of innate pattern-recognition receptors promotes CD4+ T-cell-mediated autoimmune myocarditis and subsequent inflammatory cardiomyopathy. Mechanisms that counterregulate exaggerated heart-specific autoimmunity are poorly understood. METHODS AND RESULTS: Experimental autoimmune myocarditis was induced in BALB/c mice by immunization with α-myosin heavy chain peptide and complete Freund's adjuvant. Together with interferon-γ, heat-killed Mycobacterium tuberculosis, an essential component of complete Freund's adjuvant, converted CD11b(hi)CD11c(-) monocytes into tumor necrosis factor-α- and nitric oxide synthase 2-producing dendritic cells (TipDCs). Heat-killed M. tuberculosis stimulated production of nitric oxide synthase 2 via Toll-like receptor 2-mediated nuclear factor-κB activation. TipDCs limited antigen-specific T-cell expansion through nitric oxide synthase 2-dependent nitric oxide production. Moreover, they promoted nitric oxide synthase 2 production in hematopoietic and stromal cells in a paracrine manner. Consequently, nitric oxide synthase 2 production by both radiosensitive hematopoietic and radioresistant stromal cells prevented exacerbation of autoimmune myocarditis in vivo. CONCLUSIONS: Innate Toll-like receptor 2 stimulation promotes formation of regulatory TipDCs, which confine autoreactive T-cell responses in experimental autoimmune myocarditis via nitric oxide. Therefore, activation of innate pattern-recognition receptors is critical not only for disease induction but also for counterregulatory mechanisms, protecting the heart from exaggerated autoimmunity.

Creació del web d'uns estudis de la UOC amb un sistema de gestió de continguts de codi obert

L'objectiu d'aquest treball és seleccionar un sistema de gestió de continguts de codi obert i dissenyar el web d'uns estudis de la UOC amb el programari escollit. Per a això, es comproven les capacitats d'aquest programari en la gestió del contingut del web: creació de nous continguts, expansió, permisos d'accés, flux de treball, etc.