Report of the National Physical and Sensory Disability Database Development Committee

The need for information on the health service needs of people with physical and/or sensory disabilities was first highlighted in Shaping a Healthier Future, a document which outlined the national strategy for effective healthcare in the 1990s. This strategy document identified the establishment of a national database as the means of gathering such information Download the Report here

The InterPro Database, 2003 brings increased coverage and new features.

InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).

National Physical and Sensory Disability Database - information pack

The need for information on the service needs of people with physical and/or sensory disabilities was first highlighted in Shaping a Healthier Future: A strategy for Effective Healthcare in the 1990s.  This strategy document identified the establishment of a national database as the means of gathering such information.  Subsequently, the report of the Review Group on Health and Personal Social Services for People with Physical and Sensory Disabilities, Towards an Independent Future, identified the lack of reliable information on the numbers of people with a physical and/or sensory disability needing a health and personal social service and their precise service needs. Download the Report here

TFC de base de dades relacionals

El projecte consisteix en crear un disseny de base de dades segons els requeriments del client, en aquest cas la comunitat Europea, que emmagatzemi les dades de la futura aplicació que gestionarà les votacions ciutadanes. A més del disseny de la base de dades, el projecte haurà d'incorporar una sèrie de processos que consultin dades que podran ser demanades pel programari que faci la interacció amb els usuaris. Programari que no està inclòs en aquesta fase del pla de la Comunitat Europea.

BlastR--fast and accurate database searches for non-coding RNAs.

We present and validate BlastR, a method for efficiently and accurately searching non-coding RNAs. Our approach relies on the comparison of di-nucleotides using BlosumR, a new log-odd substitution matrix. In order to use BlosumR for comparison, we recoded RNA sequences into protein-like sequences. We then showed that BlosumR can be used along with the BlastP algorithm in order to search non-coding RNA sequences. Using Rfam as a gold standard, we benchmarked this approach and show BlastR to be more sensitive than BlastN. We also show that BlastR is both faster and more sensitive than BlastP used with a single nucleotide log-odd substitution matrix. BlastR, when used in combination with WU-BlastP, is about 5% more accurate than WU-BlastN and about 50 times slower. The approach shown here is equally effective when combined with the NCBI-Blast package. The software is an open source freeware available from www.tcoffee.org/blastr.html.

Adjuvant intra-arterial hepatic fotemustine for high-risk uveal melanoma patients

Uveal melanoma metastases occur most commonly in the liver. Given the 50% mortality rate in patients at high risk of developing liver metastases, we tested an adjuvant intra-arterial hepatic (i.a.h.) chemotherapy with fotemustine after proton beam irradiation of the primary tumour. We treated 22 high-risk patients with adjuvant i.a.h. fotemustine. Planned treatment duration was 6 months, starting with four weekly doses of 100 mg/m(2), and after a 5-week rest, repeated every 3 weeks. The survival of this patient group was compared with that of a 3 : 1 matched control group randomly selected from our institutional database. Half of the patients experienced > or =grade 3 hepatotoxicity (one patient developing cholangitis 8 years later). Catheter-related complications occurred in 18%. With a median follow-up of 4.6 years for the fotemustine group and 8.5 years for the control group, median overall survival was 9 years [95% confidence interval (CI) 2.2-12.7] and 7.4 years (95% CI 5.4-12.7; P=0.5), respectively, with 5-year survival rates of 75 and 56%. Treatment with adjuvant i.a.h. fotemustine is feasible. However, toxicities are important. Although our data suggest a survival benefit, it was not statistically significant. Confirming such a benefit would require a large, internationally coordinated, prospective randomized trial.

FoodMicro Database

The food industry on the island of Ireland carries out extensive testing of their food products but results of these analyses are not normally released for public evaluation.

Web semántica: RDF y SGBD que lo soportan

En aquest treball es fa una breu introducció a la web semàntica i el seu estat actual. S'analitzen els llenguatges que hi ha a la base del munt de recomanacions del World Wide Web Consortium (XML, XML Schema, RDF i RDF Schema) i s'examinen diferents sistemes de gestió de bases de dades que donen suport a les metadades, que són la base de la web semàntica.

XML/XQuery Languages : estat de l'Art

Aquesta memòria vol introduir el lector dins del camp de l'XML, fent referència al mateix llenguatge XML i a l'anomenada família XML, formada per totes les tecnologies i els estàndards que estan relacionats amb l'XML i que en fan un llenguatge realment potent i versàtil.

XML i Web Semàntica

En aquest treball es realitza una descripció dels llenguatges que constitueixen la base de la construcció de la Web Semàntica: l'XML, l'RDF i l'OWL. En concret, es realitza un estudi de la base de dades lèxica WordNet. Finalment, es presenta el disseny i la implementació d'una ontologia per representar les relacions lèxiques dels mots del català. A partir d'aquesta ontologia es crea una petita base de dades basada en la temàtica dels animals de companyia. Aquest cas pràctic permet extreure conclusions sobre els avantatges d'introduir metadades en els documents electrònics, i sobre les facilitats que ofereixen les aplicacions actuals pel desenvolupament d'aquest tipus de documents.

The Eukaryotic Promoter Database EPD: the impact of in silico primer extension.

The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of eukaryotic POL II promoters, experimentally defined by a transcription start site (TSS). There may be multiple promoter entries for a single gene. The underlying experimental evidence comes from journal articles and, starting from release 73, from 5' ESTs of full-length cDNA clones used for so-called in silico primer extension. Access to promoter sequences is provided by pointers to TSS positions in nucleotide sequence entries. The annotation part of an EPD entry includes a description of the type and source of the initiation site mapping data, links to other biological databases and bibliographic references. EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets for comparative sequence analysis. Web-based interfaces have been developed that enable the user to view EPD entries in different formats, to select and extract promoter sequences according to a variety of criteria and to navigate to related databases exploiting different cross-references. Tools for analysing sequence motifs around TSSs defined in EPD are provided by the signal search analysis server. EPD can be accessed at http://www.epd. isb-sib.ch.

XML / XQuery Languages : estado del arte

Aquest treball fa un recull d'informació de l'estàndard XML i dels llenguatges de consultes XQuery, que són llenguatges de consultes dissenyats per a fer accessos a aquest tipus de dades.

Analysis of the National Childhood Obesity Database 2005-06

This report looks at the first year of data collection on childhood obesity and the difficulties of this project. This report summarises the data available and provides high level analysis of the prevalence of overweight and obesity among the children measured in 2005-06. The report was produced for the Department of Health by the South East Public Health Observatory on behalf of the Association of Public Health Observatories, and published in December 2006.

Analysis of the national childhood obesity database 2005-06

A report for the Department of Health by the South East Public Health Observatory on behalf of the Association of Public Health Observatories. The report looks at the first year of data collection on childhood obesity and the difficulties of this project. This report summarises the data available and provides high level analysis of the prevalence of overweight and obesity among the children measured in 2005-06.