Elaboração de manual da qualidade e manual de segurança em laboratório para a unidade operacional de equivalência farmacêutica da UNESP

No ambiente competitivo em que as empresas estão inseridas, verifica-se um crescimento significativo da divulgação sobre a importância de uma gestão adequada, objetivando a manutenção de sua sustentação competitiva. As exigências de mercado fazem crescer continuamente a preocupação em implantar Sistemas de Gestão da Qualidade, não só no universo das grandes corporações, mas também das empresas prestadoras de serviços, como por exemplo, os laboratórios de ensaio. A Promulgação da Lei dos medicamentos Genéricos (LEI 9787), por meio da RDC 299/99 estabelece que os laboratórios possuem o dever de prestar serviços que atendam aos princípios fundamentais de gestão da qualidade analítica e de boas práticas de laboratório. Nesse contexto e visando a condução dos ensaios exigidos para o registro de medicamentos genéricos, a Rede Brasileira de Laboratórios Analíticos em Saúde teve sua origem. Dentre os requisitos estabelecidos pela REBLAS para habilitação de laboratórios na condução de ensaios de Equivalência Farmacêutica, é determinado que “o laboratório deve estabelecer, implementar e manter um Sistema da Qualidade apropriado ao escopo das suas atividades” (ANVISA, 2002). Assim, torna-se indispensável a existência de um Manual da Qualidade, ferramenta que descreve o Sistema de Gestão da Qualidade de acordo com a política e objetivos que são declarados pela organização, bem como um Manual de Segurança em Laboratório para a Unidade Operacional de Equivalência Farmacêutica da UNESP.

Por trás da qualidade: inter-relações das Relações Públicas e os sistemas de gestão de qualidade

This study examines some characteristics of the contemporary reality and its influence on the dynamics of the organizational activities, in particular, related to the quality management. Discusses capitalist logic of maximization of profits that has been sophisticated in face of new scenarios that arise with society evolution. It also proposes a reflection on the philosophies and formats of management that fits with the desire to meet the needs of society through the expansion of quality - now a reference for the production processes and management systems. The work highlights the relations between communication and quality, pointing them as fundamental to the use of fissures on the evolution of the capitalist system in developing programs, philosophies and management systems. The intention is to turn able ways to contemplate the needs and interests of the largest number of public and variables in a different relation than the usual, in which a few wins and many lose

Melhoria da qualidade de um processo de usinagem utilizando as técnicas de avaliação de Taguchi

Delivering to the customers a product or service with the expected quality associated to the huge competitiveness that exists in the market nowadays, has been making organizations increasingly focus on quality planning using techniques which are directed towards the continuous improvement process and production optimization. Thus, this paper aims to improve a machining process using the techniques of experimental design to the optimization and this also includes the analysis of the measurement system. For this purpose, the alloy Nimonic 80A, a nickel base superalloy, was used in the process due to its widespread use for high temperatures, applying this study the robust method proposed by Genichi Taguchi, determining the influence of the factors considered input variables, cutting speed, feed rate, depth of cut, type of tool, lubrication, and material hardness, in the output or response variable, surface roughness, concluding with the use of Taguchi orthogonal array L16 and by analysis of ANOVA that the factor feed rate is significant and offers greater effect on the response variable studied, should be set to 0,12mm/rev. Moreover, the factor type of tool has more influence on the process when compared to other factors, being CP250 the one more suitable to the process. Lastly, the interaction feed rate x cutting speed provides greater significance in the process regarding to surface roughness variable, being the best match between them 0,12mm/rev to the feed rate and 90m/min to the cutting speed. In order to evaluate the measurement system, it was applied the repeatability and reproducibility method (R&R), through which we saw that the system needs improvement (R & R = 88.04% >>> 30%) as the value found in the study was well above compared to the one that classifies the system as inappropriate

Qualidade da construção civil de estrutura de concreto armado, alvenaria de vedação e revestimento externo de obras verticais

The main purpose of this research is to raise, through lab rehearsals, the geometric properties of some oxisols from the region of Vale do Paraíba as well as comparing them to demands prescribed by Technical Specifications ESP08/05 of the Road Department of the State of Paraná, for sub-base or fine grained lateritic soil base (SAFL) and in the Technical Specification ET-DEP00/006 of the Road Department of the State of São Paulo (DER/SP) for subbase or crushed stone base. According to the results that were obtained it will be feasible to appraise the usage of these sorts of soils in structure layers of low-weight traffic pavements

Ciclo PDCA e ferramentas da qualidade em operações e serviços de e-commerce

The market has forced companies to maintain high levels of control over their processes , ensuring a product or service quality to its customers . This study comes in the issuance and registration carried out in a company of e-commerce , which is showing problems with the values of weights and dimensions used in the cases cited . The need to eliminate wasteful spending freight caused by shipment of products weighing more than the reality, and to increase the reliability of the information used in the management of processes led to the planning of this project . This work focuses on the development of a PDCA cycle to work in the identification and correction of the causes of the problem , in order to neutralize the current complications and ensure that the problem does not appear again. To aid the mapping of the processes involved , identifying the causes of the problem and implementation of the proposed improvements were used quality tools such as flowcharts , Ishikawa diagrams , Pareto diagrams , and applied statistics

Avaliação da qualidade da água no sistema de abastecimento da cidade de Santa Lúcia - SP

água que abastece uma cidade se não for tratada pode tornar-se importante veículo de transmissores de doenças. O controle da qualidade é uma medida que visa, principalmente, garantir a saúde da população. O objetivo desta pesquisa foi avaliar a qualidade da água distribuída pelo sistema de abastecimento da cidade de Santa Lúcia – SP. A água proveniente desse sistema chega até as residências e, muitas vezes, é consumida sem nenhum tratamento doméstico complementar. A cidade de Santa Lúcia é abastecida por três poços profundos (P2, P3, e P4). Com o intuito de avaliar a qualidade da água captada desses poços e distribuídas para consumo humano foram coletadas amostras diretamente dos poços e de um ponto de consumo nas áreas abastecidas por cada poço. Foram feitas três coletas em cada ponto, em três diferentes épocas do ano. Realizaram-se análises físico-químicas e bacteriológicas em todas as amostras. As análises bacteriológicas foram feitas para determinação da presença de coliformes totais, E. coli e contagem padrão de bactérias heterotróficas em placa. As análises físico-químicas avaliaram cloro residual livre, fluoreto, turbidez, pH, cor aparente e sólidos totais dissolvidos. Duas amostras foram positivas para coliformes totais, apenas uma amostra coletada no poço 2 foi positiva para E. coli. Para bactérias heterotróficas todas a amostras apresentaram contagem em placa inferior a 500 UFC/mL. Todas as amostras estavam dentro do padrão determinado pela legislação para pH, turbidez e sólidos totais dissolvidos. Todas as amostras coletadas no poço 2 tiveram como resultado ausência de cloro residual livre, o mesmo resultado para os demais pontos na segunda coleta de amostras. Todas as amostras apresentaram fluoreto com valores abaixo do VMP estabelecido pela legislação brasileira porém apenas cinco com concentrações dentro da faixa estabelecida pela legislação do Estado de São Paulo ...

Avaliação da qualidade de óleos de fritura utilizados em restaurante universitário

Frying is a widely used method of preparing food, because it is a very fast and convenient process, and because it provides specific characteristics of color, flavor, odor, and texture, besides having great consumer acceptance. Therefore, the interest in the physiological effects that oils heated at high temperatures can cause to the human body arises. The aim of this work was to analyze the levels of frying used oil alteration in different kinds of foods served at the university restaurant at “Instituto de Biociências, Letras e Ciências Exatas” (IBILCE), in São José do Rio Preto-SP. In addition, it aims to make the restaurant aware of the good ways to fry and the commitment of providing good quality food to students and professionals of the Institute. With this purpose, determination of total polar compounds, conjugated dienoic acids, peroxide value, and fatty acid profile were analyzed. Two rapid tests were also used: 3M Fat Monitor and Oil Test kit. The results were compared with limits recommended for the disposal of oils and fats used in frying by the Brazilian Health Surveillance Agency (ANVISA), by other countries, and by other researches. Thus, it was concluded that the university restaurant provides the consumers with fried food of good quality, since none of the analyses showed results above recommended, although there is a need of improvement in the quality control of the oil used, in order to avoid unnecessary costs to the university restaurant.

Qualidade da semeadura direta de milho com dois mecanismos de pressão no disco sulcador sob duas velocidades

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Implantação do controle estatístico de processo: um estudo de caso em uma empresa do setor alimentício

Pós-graduação em Engenharia de Produção - FEB

Recomendações para criação e gerenciamento de um sistema da qualidade em empresas de autopeças

This paper addresses the difficulties and best practices of a quality system of an automotive parts company. In it will be discussed the features and benefits of the proper use of a system of management and quality assurance. It emphasizes the proper use of tools and methodologies that aim improving the quality of processes and products. It also has some guidance information given by the standards of quality which helps the implementation of the quality system and the standards are important because it attests to the quality of companies. So, this work has as objective to guide the creation and management of the quality system in auto parts companies, which seek an increase in the quality of products and processes, it also helps to certify companies in the current quality standard for the sector, ISO TS 16949, and thus increases the competitiveness of companies in this market. As result, this paper resumes good practices, difficulties and key steps for creating and managing a quality system

Efeito do envelhecimento na qualidade da cachaça produzida por pequenos produtores

This article reports the results of a study that aimed at evaluating the effects of aging technique on cachaça samples produced and sold by small farmers in São Paulo State, Brazil. Cachaças, aged and not aged were sent by 10 cachaça producers that take part in the community project and course: São Paulo State Contest of Distillery Cachaça and Production Chain of Cachaça Meeting, organized by the Food and Nutrition Department of Pharmaceutical Sciences University, UNESP/Araraquara, SP, Brazil, in partnership with the Brazilian Service of Support to Micro and Small Enterprise of São Paulo State (SEBRAE-SP) and the Rural Union of Araraquara. The evaluation of the samples was made based on sensory tests conducted in Analysis and Quality Control of Foods and Drinks Laboratory of the Department. The survey results showed significantly higher acceptance average in the aged samples compared with not aged ones. The aging process, which was one of the topics discussed in the course, was considered as an effective way to improve the quality of cachaça, the research also confirmed the importance of the University support to improve the quality of food and drink produced in Brazil.

Efeito da adição de açúcares e do processo de envelhecimento na qualidade sensorial de amostras de cachaça obtidas tradicionalmente e por redestilação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A importância da atenção farmacêutica após a verificação da qualidade microbiológica de medicamentos contendo paracetamol encontrados em algumas residências de Américo Brasiliense - SP

It is known that a high microbial count can compromise the stability of medicines, thus reducing their therapeutic efficacy. This work tried to demonstrate that the microbial contamination can be directly related to the inadequate handling of the medicines stored in homes, making it possible to draw strategies to reduce the possible risks of medical therapy offering correct information and advising. The objective of this work was to evaluate the quality of the medicines containing paracetamol found in the residences of Américo Brasiliense-SP, using the microbial analysis of non-sterile method described in the Brazilian Pharmacopoeia (1988). The medicine samples (30 samples) were obtained directly from the interviewed local residents, who had received new medicine bottles of the same product. An analysis of viable microorganisms (bacteria and fungus) was carried out to identify pathogens found in the collected samples. Although 90% of the analyzed samples have shown some microbial contamination, the results indicated the absence of pathogenic microorganisms, and the total count of viable microorganisms was below the maximum value for non-sterile (104 UFC/g or mL). It was also verified that the local residents stored the medicines in appropriate places, according to the orientations received when they bought the medicines in pharmacies and drugstores, showing the importance of information for the correct use and conservation of pharmaceuticals.

Farmácia magistral: sua importância e seu perfil de qualidade

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Qualidade dos processos mecanizados de semeadura e colheita na cultura da soja

Pós-graduação em Agronomia (Produção Vegetal) - FCAV