Army Civilian Training, Education, & Development System : ACTEDS plan for DA engineers and scientists (non-construction) CP-16 : foundation for the U.S. Army University for DA Engineers & Scientists (NC).

Mode of access: Internet.

Georgius Syncellus et Nicephorus Cp.

The Chronographia of Georgius Sycellus is an outline of history from Adam to 285. The Chronographia brevis of Nicephorus is a chronological table of events from Adam to 829.

Organizational maintenance repair parts and special tools list for computer, communications CP-1527/TYC-39(V) (NSN 5805-01-120-2919).

"18 November 1985."

Organizational and direct support maintenance manual : data processing unit CP-1435/MYQ-4, (NSN 7010-01-092-2549).

Includes index.

The variation of (k[rho]cp̳)¹/² with temperature in "Pyrex."

On t. p., p̳ is subscript.

Monthly Cement Report No. CP

Mode of access: Internet.

SOU CP NA EDUCAÇÃO INFANTIL, E AGORA? UM ESTUDO SOBRE O PAPEL DO COORDENADOR PEDAGÓGICO COMO FORMADOR DE PROFESSORES

O presente trabalho busca examinar as dificuldades que o coordenador pedagógico tem encontrado no processo de construção de sua identidade como formador de professores de Educação Infantil, tanto do ponto de vista individual, como institucional. O quadro teórico gira em torno da obra de Paulo Freire, para discutir a concepção de educação e formação de professores numa visão mais humanista, mais comprometida com o homem inserido num mundo moderno e em constante transformação e, portanto, inacabado; Madalena Freire possibilita desvelar os meandros da formação docente na Educação Infantil; José Cerchi Fusari contribui para a discussão da formação inicial e continuada, descrevendo e analisando as representações dos coordenadores pedagógicos; finalmente, Vera Maria Nigro de Souza Placco aborda a formação em serviço como um conjunto de relações interpessoais e o trabalho do coordenador pedagógico como possibilidade de aprendizagem do adulto professor. A pesquisa foi realizada com oito coordenadores pedagógicos de escolas públicas de Educação Infantil sob responsabilidade da Secretaria Municipal de Educação de São Paulo, todos efetivos e com permanência no cargo variando de um ano e sete meses a 23 anos. A metodologia utilizada foi a análise dos conteúdos coletados nas entrevistas, as quais foram gravadas em áudio e depois transcritas. As perguntas da pesquisa foram aprofundadas ao longo do desenvolvimento deste trabalho e, respeitando-se o quadro teórico, foi elaborado um roteiro temático com questões semiestruturadas. A conclusão da pesquisa aponta para o fato de que a identidade do coordenador pedagógico de Educação Infantil não é algo pronto, acabado. A identidade se faz no dia a dia, nas relações intra e interpessoais, no diálogo com o grupo, na construção de rotinas e na partilha das responsabilidades, bem como no trabalho integrado e articulado com a direção da escola.

La Classe Borélienne Ne Détermine Pas Le Type Topologique De Cp(x)

We prove that, for every countable ordinal α ≥ 3, there exists countable completely regular spaces Xα and Yα such that the spaces Cp (Xα ) and Cp (Yα ) are borelian of class exactly Mα , but are not homeomorphic.

CP-036 evaluation of outpatient clinic letters for medication errors

Background - It is well recognised that errors are more likely to occur during transitions of care, especially medicines errors. Clinic letters are used as a communication tool during a transition from hospital (outpatient clinics) to primary care (general practitioners). Little is known about medicines errors in clinic letters, as previous studies in this area have focused on medicines errors in inpatient or outpatient prescriptions. Published studies concerning clinic letters largely focus on perceptions of patients or general practitioners in respect to overall quality. Purpose - To investigate medicines errors contained in outpatient clinic letters generated by prescribers within the Neurology Department of a specialist paediatric hospital in the UK.Materials and methods - Single site, retrospective, cross-sectional review of 100 clinic letters generated during March–July 2013 in response to an outpatient consultation. Clinic letters were conveniently selected from the most recent visit of each patient. An evaluation tool with a 10-point scale, where 10 was no error and 0 was significant error, was developed and refined throughout the study to facilitate identification and characterisation of medicines errors. The tool was tested for a relationship between scores and number of medicines errors using a regression analysis.Results - Of 315 items related to neurology mentioned within the letters, 212 items were associated with 602 errors. Common missing information was allergy (97%, n = 97), formulation (60.3%, n = 190), strength/concentration (59%, n = 186) and weight (53%, n = 53). Ninety-nine letters were associated with at least one error. Scores were in range of 4–10 with 42% of letters scored as 7. Statistically significant relationships were observed between scores and number of medicines errors (R2 = 0.4168, p < 0.05) as well as between number of medicines and number of drug-related errors (R2 = 0.9719, p < 0.05). Conclusions - Nearly all clinic letters were associated with medicines errors. The 10-point evaluation tool may be a useful device to categorise clinic letter errors.

The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility

The interplay between long-term potentiation and long-term depression (LTD) is thought to be involved in learning and memory formation. One form of LTD expressed in the hippocampus is initiated by the activation of the group 1 metabotropic glutamate receptors (mGluRs). Importantly, mGluRs have been shown to be critical for acquisition of new memories and for reversal learning, processes that are thought to be crucial for cognitive flexibility. Here we provide evidence that MAPK-activated protein kinases 2 and 3 (MK2/3) regulate neuronal spine morphology, synaptic transmission and plasticity. Furthermore, mGluR-LTD is impaired in the hippocampus of MK2/3 double knockout (DKO) mice, an observation that is mirrored by deficits in endocytosis of GluA1 subunits. Consistent with compromised mGluR-LTD, MK2/3 DKO mice have distinctive deficits in hippocampal-dependent spatial reversal learning. These novel findings demonstrate that the MK2/3 cascade plays a strategic role in controlling synaptic plasticity and cognition. © 2014 Macmillan Publishers Limited. All rights reserved.

Activity-regulated cytoskeleton-associated protein controls AMPAR endocytosis through a direct interaction with clathrin-adaptor protein 2

The activity-regulated cytoskeleton-associated (Arc) protein controls synaptic strength by facilitating AMPA receptor (AMPAR) endocytosis. Here we demonstrate that Arc targets AMPAR to be internalized through a direct interaction with the clathrin-adaptor protein 2 (AP-2). We show that Arc overexpression in dissociated hippocampal neurons obtained from C57BL/6 mouse reduces the density of AMPAR GluA1 subunits at the cell surface and reduces the amplitude and rectification of AMPAR-mediated miniature-EPSCs (mEPSCs). Mutations of Arc, that prevent the AP-2 interaction reduce Arc-mediated endocytosis of GluA1 and abolish the reduction in AMPAR-mediated mEPSC amplitude and rectification. Depletion of the AP-2 subunit µ2 blocks the Arc-mediated reduction in mEPSC amplitude, an effect that is restored by reintroducing µ2. The Arc-AP-2 interaction plays an important role in homeostatic synaptic scaling as the Arc-dependent decrease in mEPSC amplitude, induced by a chronic increase in neuronal activity, is inhibited by AP-2 depletion. These data provide a mechanism to explain how activity-dependent expression of Arc decisively controls the fate of AMPAR at the cell surface and modulates synaptic strength, via the direct interaction with the endocytic clathrin adaptor AP-2.

Az észlelt kultúraszemélyiség és hatása az ország turisztikai és üzleti célpontként való megítélésére (Investigation the effect of perceived culture – personality (CP) on the evaluation of the country as ideal business/tourist destination)

A kutatás fő célja annak vizsgálata, hogy egy adott kultúra észlelt személyisége milyen hatással van az ország ideális turisztikai, illetve üzleti célországként való megítélésére. A kultúraszemélyiség koncepciójának bemutatása után a kultúraszemélyiség-skála (culture personality, CP) fejlesztésének kezdeti eredményeit, majd a kultúraszemélyiség dimenzióinak vizsgálatát részletezik a szerzők. A skálakialakítás során – kvalitatív eredményeiket felhasználva – egy ötvenegy tulajdonságpárból álló szemantikus differenciálskálát fejlesztettek ki és teszteltek. Jelen cikkükben összehasonlítják Franciaország és Magyarország észlelt kultúraszemélyiségét, vizsgálva a magyar és a francia válaszadók véleményének hasonlóságait és különbségeit. Eredményeik azt mutatják, hogy nemcsak az egyes kultúrák személyiségét észlelik eltérően a válaszadók, de ugyanazon kultúra személyiségének bizonyos jellemzőit is eltérően ítélik meg. _____ The main purpose of our study was to investigate the effect of perceived culture – personality (CP) on the evaluation of the country as ideal business/tourist destination. After introducing the concept of culture-personality, initial results of our CP scale development are discussed, and dimensions of culture-personality will be examined. As a result of the scale construction procedure – based on our extensive qualitative studies –, a 51-item semantic differential scale has been developed and tested. Similarities and differences of perceived culture-personalities of France and Hungary among Hungarian and French respondents are described.

Effet du CP-3(iv), un ligand du récepteur CD36, sur le stress oxydatif suite à une ischémie cardiaque transitoire chez la souris

Le récepteur éboueur CD36 facilite l’internalisation des acides gras libres non estérifiés (AGNE) au niveau des tissus cardiaque et périphériques. Lors d’une ischémie-reperfusion du myocarde (MI/R), les dommages produits sont en partie liés à l’internalisation des AGNE et à la production d’espèces réactives de l’oxygène, contrairement à ce qui est observé chez des souris déficientes en CD36 (CD36-/-). Nous avons émis l’hypothèse selon laquelle le CP-3(iv), un ligand synthétique du récepteur CD36, exercerait un effet cardioprotecteur en réduisant la taille de la zone myocardique infarcie lors d’une ischémie transitoire du myocarde. Nos objectifs étaient 1) de déterminer l’effet cardioprotecteur du CP-3(iv) et 2) de définir son mécanisme. Pour cela, des études in vivo et ex vivo ont été faites. Des souris de type sauvage ont été traitées avec le CP-3(iv) (289 nmol/kg) par voie sous-cutanée pendant 14 jours avant d’être soumises à 30 minutes d’ischémie suivant la ligature de l’artère coronaire gauche descendante et de sa reperfusion pendant une période de 6 ou 48 heures. De plus, des coeurs isolés de souris ont été perfusés 30 minutes, suivi de 40 minutes à faible débit (10%) et de 30 minutes de reperfusion pendant laquelle le coeur est perfusé avec le CP-3(iv) à une concentration de 10-6 M. Nos travaux ont montré que l’effet cardioprotecteur d’un traitement préventif par le CP-3(iv) permet de diminuer la taille de l’infarctus et préserve l’hémodynamie cardiaque de façon dépendante du CD36 puisque cet effet est non visible chez les souris CD36-/-. De plus, le CP-3(iv) exerce non seulement un effet systémique, mais aussi un effet cardioprotecteur direct sur le coeur isolé.

Diminuição da expressão dos genes APP e CP em doentes de Alzheimer sugere alteração da exportação de ferro celular nesta demência

Recentemente tem-se assistido a um acumular de evidência sugerindo a implicação de uma desregulação do metabolismo do ferro (Fe) na fisiopatologia da doença de Alzheimer (DA). Neste trabalho, pretendemos esclarecer melhor os mecanismos moleculares subjacentes à homeostasia deste metal na DA, particularmente ao nível do efluxo celular. Assim, mediu-se em células mononucleares do sangue periférico de 73 doentes com DA e 74 controlos a expressão de genes diretamente envolvidos na regulação e exportação celular de Fe, utilizando a técnica de PCR quantitativo. Os resultados mostraram uma diminuição significativa na expressão dos genes aconitase (ACO1; P=0,007); ceruloplasmina (CP; P<0,001) e proteína precursora de beta amilóide (APP; P=0,006) em doentes com DA comparativamente com os voluntários saudáveis. Estas observações apontam para uma diminuição significativa da expressão dos genes associados com a exportação de Fe celular mediada pela ferroportina na DA. Assim, o presente estudo reforça resultados anteriores que mostram alterações no metabolismo do Fe e podem estar na origem da retenção intracelular deste metal e aumento de stress oxidativo caraterísticos desta patologia.