Predicting the Risk of Lung Cancer in Never-smokers

Despite being considered a disease of smokers, approximately 10-15% of lung cancer cases occur in never-smokers. Lung cancer risk prediction models have demonstrated excellent ability to discriminate cases from non-cases, and have been shown to be more efficient at selecting individuals for future screening than current criteria. Existing models have primarily been developed in populations of smokers, thus there was a need to develop an accurate model in never-smokers. This study focused on developing and validating a model using never-smokers from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cox regression analysis, with six-year follow-up, was used for model building. Predictors included: age, body mass index, education level, personal history of cancer, family history of lung cancer, previous chest X-ray, and secondhand smoke exposure. This model achieved fair discrimination (optimism corrected c-statistic = 0.6645) and good calibration. This represents an improvement on existing neversmoker models, but is not suitable for individual-level risk prediction.

Métis or Moniyâw: Explorative stories of decolonizing my Métis identity

This thesis explores my emergent processes of identifying as a Métis person through autoethnographic narratives. I provide an overview of Métis history, identification, and decolonization, especially written by and for Aboriginal peoples. Using a decolonizing framework of Indigenous métissage (Donald, 2012) – which brings together complex, and nuanced influences to build knowledge – and an autoethnographic methodology, I explore cultural knowledges through critical self-reflection. I collected autoethnographic data in the form of personal journals and family artifacts; additionally, I shared conversations with other Métis peoples, which I used to further inform my own processes of identification and decolonization. The study results are presented as narrative vignettes, offering conclusions about: a) cultural ambivalence; b) privilege; c) language and music reclamation; and d) building relationships with both people and land. This research builds upon literature by, about, and for the benefit of Aboriginal peoples and settlers and offers considerations relevant to decolonization and identification.

Factors Associated with Small Aggressive Non-Small Cell Lung Carcinomas

Small aggressive non-small cell lung carcinomas (SA-NSCLC) are characterized by spread to distant lymph nodes and metastases, even while the primary tumour remains small in size, as opposed to tumours that are relatively large before cancer progression. These small aggressive cancers present a challenge for clinical diagnosis and screening, carry grave prognosis, and may benefit from using a targeted approach to identify high-risk individuals. The objectives of this thesis were to identify factors associated with SA-NSCLC, and compare survivorship of stage IV SA-NSCLC to large stage IV NSCLC. Logistic and Cox regression analysis were performed using data from the National Lung Screening Trial (NLST). Model building was guided by knowledge of lung carcinogenesis and lung cancer prognostic factors. Previous diagnosis of emphysema and positive family history of lung cancer in females were associated with increased risk of SA-NSCLC among adenocarcinomas. Despite overall poor prognosis, SA-NSCLC have a better prognosis compared to large stage IV NSCLC.

Geology of Hebes Chasma, Valles Marineris, Mars

Hebes Chasma is an 8 km deep, 126 by 314 km, isolated basin that is partially filled with interior layered deposits (ILD), massive deposits of water altered strata. By analyzing the ILD’s structure, stratigraphy and mineralogy, as well as the perimeter faults exposed in the plateau adjacent to the chasma, the evolution and depositional history of Hebes Chasma is interpreted. Three distinct ILD units were found and are informally referred to as the Lower, Upper and Late ILDs. These units have differing layer thicknesses, layer attitudes, mineralogies and erosional landforms. Based on observations of the plateau, wall morphology and slump blocks within the chasma’s interior, chasma evolution appears to be controlled by cross-faults that progressively detached sections of the wall. A scenario involving the loss of subsurface volume and ash fall events is proposed as the dominant setting throughout Hebes’ geologic history.

Roberta "Bobbie" Styran fonds, 1707-2013, n.d.

Roberta “Bobbie” Styran was born and rasied in Fredericton, N.B. She graduated from McMaster University with a B.A. (1962) and M.A. (1964), before furthering her studies at the University of Toronto, where she received a Ph. D in History. From 1967 to 1978, she taught Medieval History at Brock University, where she developed an interest in the Welland Canal. She began a collaboration with Prof. Robert R. Taylor of the History Department at this time, researching the history of the Welland Canals. She later moved to Toronto and worked for the Ministry of Education, but returned to St. Catharines in 1988 to facilitate her work with Prof. Taylor. The two have co-authored several books, including The Welland Canals: the Growth of Mr. Merritt’s Ditch; Mr. Merritt’s Ditch: A Welland Canals Album; The Great “Swivel Link”: Canada’s Welland Canal and This Great National Object: Building the Nineteenth-Century Welland Canals. Bobbie travelled extensively, visiting many canal and industrial revolution sites in Great Britain and the United States. She was active in many canal associations, including the Canadian Canal Society (where she served as president and editor of the Society’s newsletter), the American Canal Society, and the Council of Inland Waterways International. She also helped to found the Welland Canals Preservation Association and organized and chaired the 2004 World Canals Conference at Brock University. In 2009, she received the W. Gordon Plewes Award from the Canadian Society for Civil Engineering, an award that recognized her services to Canadian engineering history.

Force potentiation as a modulator of contractile performance: Implications for control of skeletal muscle force and energetics of work

This thesis investigated the modulation of dynamic contractile function and energetics of work by posttetanic potentiation (PTP). Mechanical experiments were conducted in vitro using software-controlled protocols to stimulate/determine contractile function during ramp shortening, and muscles were frozen during parallel incubations for biochemical analysis. The central feature of this research was the comparison of fast hindlimb muscles from wildtype and skeletal myosin light chain kinase knockout (skMLCK-/-) mice that does not express the primary mechanism for PTP: myosin regulatory light chain (RLC) phosphorylation. In contrast to smooth/cardiac muscles where RLC phosphorylation is indispensable, its precise physiological role in skeletal muscle is unclear. It was initially determined that tetanic potentiation was shortening speed dependent, and this sensitivity of the PTP mechanism to muscle shortening extended the stimulation frequency domain over which PTP was manifest. Thus, the physiological utility of RLC phosphorylation to augment contractile function in vivo may be more extensive than previously considered. Subsequent experiments studied the contraction-type dependence for PTP and demonstrated that the enhancement of contractile function was dependent on force level. Surprisingly, in the absence of RLC phosphorylation, skMLCK-/- muscles exhibited significant concentric PTP; consequently, up to ~50% of the dynamic PTP response in wildtype muscle may be attributed to an alternate mechanism. When the interaction of PTP and the catchlike property (CLP) was examined, we determined that unlike the acute augmentation of peak force by the CLP, RLC phosphorylation produced a longer-lasting enhancement of force and work in the potentiated state. Nevertheless, despite the apparent interference between these mechanisms, both offer physiological utility and may be complementary in achieving optimal contractile function in vivo. Finally, when the energetic implications of PTP were explored, we determined that during a brief period of repetitive concentric activation, total work performed was ~60% greater in wildtype vs. skMLCK-/- muscles but there was no genotype difference in High-Energy Phosphate Consumption or Economy (i.e. HEPC: work). In summary, this thesis provides novel insight into the modulatory effects of PTP and RLC phosphorylation, and through the observation of alternative mechanisms for PTP we further develop our understanding of the history-dependence of fast skeletal muscle function.

Understanding the Intersection of Reformed Faith and Dutch Immigrant Culture in Ontario Independent Christian Schools: Principals’ Experiences and Perspectives

In the aftermath of World War II, a wave of Dutch Reformed immigrants arrived in Ontario, many of whom joined the Christian Reformed Church. Following familiar cultural patterns, history, and their Reformed Christian faith, these immigrants settled in Ontario with remarkable institutional completeness (Breton, 1964). They quickly established independent, parent-operated Christian schools across Ontario. The primary purpose of the schools was to educate children through a comprehensive biblically based school program, yet this religious purpose often intersected with a Dutch immigrant ethnic culture. Van Dijk (2001) states that “the schools were the most important organization in maintaining the religious and ethnic identity of Calvinists” (p. 66). In this qualitative study I explore the intersection of Reformed faith and Dutch Canadian immigrant ethnic culture in Christian schools through the experiential and professional lens of eight retired principals. Employing a theoretical framework informed by Berger’s (1967) Sacred Canopy, I suggest that the intersection of faith and culture was experienced in the schools and was embodied by the schools themselves. Findings point to this intersection being located in the participants’ experience of (a) Dutchness, (b) the struggle for Christian education, (c) the ties that bound the school community together, and (d) the cloud of witnesses that founded and continues to support and encourage the Christian school community. The study offers insight into a Dutch Reformed immigrant group’s experience carving out a niche for themselves on the educational landscape in Ontario. This study also offers suggestions on how Christian schools can broaden their canopy and become more ethnically and denominationally diverse in the future.

Preservation of Agricultural Lands Society (PALS) fonds, 1954-2015, n.d.

Preservation of Agricultural Lands Society [PALS] held its first meeting at Brock University on June 21, 1976. Its first executive consisted of Robert Hoover, Rick Teather, Debbie Kehler and Bill Forster. Some objectives of the organization were "to seek the preservation of valuable farm areas from non-agricultural expansion and development and to foster development and support of federal, provinicial and local policy which will provide a secure financial future for farming." Gracia Janes and John Bacher are some of the organizations' well known advocates. The organization was active in raising public awareness of the issues surrounding encroaching development onto existing agricultural lands. The organization is still active today [2016] in educating the public and attempting to influence governments at all levels to protect valuable agricultural lands.

Cumulative index, Illinois General Assembly Oral History Program /

Lists names of all people and organizations referred to in the memoirs.

Memorial book of the sesquicentennial celebration of the founding of the College of New Jersey and of the ceremonies inaugurating Princeton University.

"Published for the Trustees of Princeton University."

The laws and jurisprudence of England and America : being a series of lectures delivered before Yale University /

"Being a series of lectures delivered before Yale University."--T.p.

Watching football in marvellous Melbourne : spectators, barrackers and working class rituals

A study of crowds drawn to Australian football matches in colonial Victoria illuminates key aspects of the code's genesis, development and popularity. Australian football was codified by a middle-class elite that, as in Britain, created forms of mass entertainment that were consistent with the kind of industrial capitalist society they were attempting to organise. But the 'lower orders' were inculcated with traditional British folkways in matters of popular amusement, and introduced a style of 'barracking' for this new code that resisted the hegemony of the elite football administrators. By the end of the colonial period Australian football was firmly entrenched as a site of contestation between plebeian and bourgeois codes of spectating that reflected the social and ethnic diversity of the clubs making up the Victorian competition. Australian football thereby offers a classic vignette in the larger history of 'resistance through ritual'.

The Corio Oval Tribe : a prosopographical perspective of the Geelong Football Club in the nineteenth century

This article analyses the occupational and class status of Geelong footballers in the nineteenth century via the methodology of prosopography. Prosopography is an empirical group biography approach to historical research. The article argues that during the period 1859-78 Geelong's playing group was largely derived from the squattocracy and urban middle class. In the later period 1878-96 the Geelong club recruited more widely from the working class, as in keeping with the increased participation of this class in football from the late 1870s. It can be argued that this more diverse group helped establish Geelong as a footballing power.